“…In addition to dismantling adherens junctions to promote delamination and migration, the cleavage of cadherin-6B results in a proteolytic product, CTF2, that functions as a transcriptional regulator to feedback and reinforce the EMT gene regulatory program (Schiffmacher et al, 2016). It was also recently shown that cleavage of cadherin-6B generates shed N-terminal fragments that promote delamination through an increase in extracellular proteolytic activity resulting in the degradation of ECM surrounding NCCs (Schiffmacher, Adomako-Ankomah, Xie, & Taneyhill, 2018). In addition to cadherin-6B, it has been demonstrated in trunk NCCs that levels of N-cadherin must be regulated for chick NCC emigration as its overexpression prevents NCC delamination (Nakagawa & Takeichi, 1998;Shoval, Ludwig, & Kalcheim, 2007).…”