Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFκB signaling pathway

Wang, Jin; Kang, Weiming; Yu, Jian-chun; Liu, Yuqin; Meng, Qingwei; Cao, Zhanjiang

doi:10.4161/cbt.23299

Cited by 25 publications

(20 citation statements)

References 39 publications

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“…CDH17 is a member of the cadherin superfamily, encoding a calcium-dependent, membrane-associated glycoprotein that is specifically expressed in the gastrointestinal tract and pancreatic ducts. Recent studies indicated that CDH17 is involved in tumourigenesis and metastasis in gastrointestinal cancers103 and may serve as a prognostic biomarker104105, although not studied previously in the context of EAC. GATA6 is one of the GATA transcription factor family members, which include GATA1–647.…”

Section: Resultsmentioning

confidence: 99%

Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas

Peng

Guo

Chen

et al. 2017

Sci Rep

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The incidence of esophageal adenocarcinoma (EAC) is rapidly rising in the United States and Western countries. In this study, we carried out an integrative molecular analysis to identify interactions between genomic and epigenomic alterations in regulating gene expression networks in EAC. We detected significant alterations in DNA copy numbers (CN), gene expression levels, and DNA methylation profiles. The integrative analysis demonstrated that altered expression of 1,755 genes was associated with changes in CN or methylation. We found that expression alterations in 84 genes were associated with changes in both CN and methylation. These data suggest a strong interaction between genetic and epigenetic events to modulate gene expression in EAC. Of note, bioinformatics analysis detected a prominent K-RAS signature and predicted activation of several important transcription factor networks, including β-catenin, MYB, TWIST1, SOX7, GATA3 and GATA6. Notably, we detected hypomethylation and overexpression of several pro-inflammatory genes such as COX2, IL8 and IL23R, suggesting an important role of epigenetic regulation of these genes in the inflammatory cascade associated with EAC. In summary, this integrative analysis demonstrates a complex interaction between genetic and epigenetic mechanisms providing several novel insights for our understanding of molecular events in EAC.

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Section: Resultsmentioning

confidence: 99%

Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas

Peng

Guo

Chen

et al. 2017

Sci Rep

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“…Instead in another cancer type, CDH17 was bridged to integrinrelated pathway during colorectal tumorigenesis because of the intrinsic integrin-binding affinity of CDH17 [20,21]. CDH17 also affects two other tumorigenic pathways related to Ras/Raf/MEK/ERK and NFκB, such that its suppression inactivated these pathways in gastric cancer [22,23]. Given these observations, it remains to be determined whether Lic5 could also block these pathways as a mean to suppress tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Survival Benefit of a Monoclonal Antibody against Cadherin-17 in an Orthotopic Liver Tumor Xenograft Model

Chan¹,

Tung²,

Lam³

et al. 2016

JALSI

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Aims: Monoclonal antibodies against tumor-related molecules are therapeutic agents for cancers. Promising results support the use of monoclonal antibodies in several cancers such as lung and breast cancer. However, using monoclonal antibodies as therapeutic agents to treat hepatocellular carcinoma (HCC), a major type of liver cancer, is still at the beginning. We have previously generated a monoclonal antibody against cadherin-17 (CDH17), named Lic5. This antibody has proven anti-tumor and cisplatin-sensitizing effect in HCC using a subcutaneous tumor xenograft mouse model.

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“…Expression level of dehydrogenase/reductase member 7 ( dhrs7 ) in rat regenerating liver was more than 968-fold compared to control [ 27 ]. Cdh17 [ 28 ] , nim1 [ 24 ] , scd, and fasn [ 29 ] were related to disease/cancer; upregulation of fasn was in accordance with elevated moderate-chain fatty acid octanoate (8 : 0). Thus, developmental process poses cancer-like characteristics.…”

Section: Discussionmentioning

confidence: 99%

ECR-MAPK Regulation in Liver Early Development

Zhao

Zhuo

2014

BioMed Research International

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Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development.

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Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFκB signaling pathway

Cited by 25 publications

References 39 publications

Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas

Integrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas

Survival Benefit of a Monoclonal Antibody against Cadherin-17 in an Orthotopic Liver Tumor Xenograft Model

ECR-MAPK Regulation in Liver Early Development

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