caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability

Abstract

One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly important in biomedical research systems, which need to coordinate a variety of disparate types of data. In order to meet this need, the National Cancer Institute Center for Bioinformatics (NCICB) has created the cancer Common Ontologic Representation Environment (caCORE), an interoperability infrastructure based on Model Driven Architecture. The caCORE infrastructure provides a mechanism to create interoperable biomedical information systems. Systems built using the caCORE paradigm address both aspects of interoperability: the ability to access data (syntactic interoperability) and understand the data once retrieved (semantic interoperability). This infrastructure consists of an integrated set of three major components: a controlled terminology service (Enterprise Vocabulary Services), a standards-based metadata repository (the cancer Data Standards Repository) and an information system with an Application Programming Interface (API) based on Domain Model Driven Architecture. This infrastructure is being leveraged to create a Semantic Service-Oriented Architecture (SSOA) for cancer research by the National Cancer Institute's cancer Biomedical Informatics Grid (caBIG).

ACCF/AHA 2011 Key Data Elements and Definitions of a Base Cardiovascular Vocabulary for Electronic Health Records

“…Clinical definitions of the selected data elements are repeated verbatim where possible as previously reported in ACCF/AHA data standards documents and/or as fields within existing registries, particularly the ACC National Cardiovascular Data Registry (NCDR), the ACC PINNACLE Registry, the AHA Get With The Guidelines Registry, and the STS National Database (15)(16)(17)(18)(19)(20)(21)(22). Source documents (noted in the Source column of each data standard table) A key focus is to perform the informatics work to build the portfolio of attributes for each of the data elements according to the International Organization for Standardization/International Electrotechnical Commission (ISO/IEC) 11179 standard (23,24), principally to facilitate adoption of these elements by the EHR vendor community. The ISO 11179 metadata repository standard provides a standard grammar and syntax for describing data elements and associated metadata that results in unambiguous representation and interpretation of data.…”

2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials

“…The terminology set will also be developed in an International Organization for Standardization/International Electrotechnical Commission 11179 standard metadata repository; this specification provides a standardized grammar and syntax for describing data elements and associated metadata, resulting in unambiguous representation and interpretation of data. 47,48 Specifically, the endpoint concepts will be represented in the National Institutes of Health/National Cancer Institute Data Standards Registry and Repository to facilitate the use of the terminology set across the clinical care, research, and regulatory domains.…”

ACCF/AHA 2011 Key Data Elements and Definitions of a Base Cardiovascular Vocabulary for Electronic Health Records

“…[15][16][17][18][19][20][21][22] Source documents (noted in the Source column of each data standard 23,24 principally to facilitate adoption of these elements by the EHR vendor community. The ISO 11179 metadata repository standard provides a standard grammar and syntax for describing data elements and associated metadata that results in unambiguous representation and interpretation of data.…”