Ca2+ signaling in mammalian spermatozoa

Finkelstein, Maya; Etkovitz, Nir; Breitbart, Haim

doi:10.1016/j.mce.2020.110953

Cited by 58 publications

(52 citation statements)

References 144 publications

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“…However, mature sperm lack these organelles and the mitochondria and some of the membranous structures of sperm contain many calcium regulatory factors (IP3R and SERCA), which may act to regulate Ca 2+ stores. It is well known that the acrosome and mitochondria provide the prominent intracellular Ca 2+ stores in mature sperm [1]. The expression level of IP3R1 decreases after the acrosome reaction, while there is no significant change in the level of IP3R3 [45].…”

Section: Expression Of Ip3rs In Male Reproductionmentioning

confidence: 96%

“…Ca 2+ serves as a second messenger in cellular signal transduction to widely regulate many intracellular events, such as gene expression, synaptic transmission, and cellular death, differentiation and proliferation. Studies have shown that calcium signaling is also involved in spermatogenesis, sperm function, and fertilization, essential processes for male reproduction [1]. Calcium ions are stored in spermatogenic cells at various developmental stages, and also in Leydig and Sertoli cells [2].…”

Section: Introductionmentioning

confidence: 99%

“…Future studies are required to verify this role. There have been many studies showing that calcium signaling regulates mature sperm function, such as the sperm acrosome reaction, capacitation, chemotaxis, and motility, as well as fertilization [1,15]. The absence of the sperm-specific calcium channel CatSper inhibited the influx of extracellular calcium, which impaired the hyperactivated mobility of sperm and led to male infertility [16].…”

Section: Introductionmentioning

confidence: 99%

“…Calcium stores combined with other key factors play critical roles in calcium homeostasis and calcium signaling. Generally, the increase in cytosolic Ca 2+ is regulated by inositol 1,4,5-trisphosphate receptors (IP3Rs), ryanodine receptor channels, transient-receptor-potential channels, cyclic-nucleotide-gated channels, transient-receptor-potential-vanilloid channels, the store-operated Ca 2+ -channel and CatSper channel [1]. A decrease in cytosolic Ca 2+ is regulated by the Ca 2+ -ATPase, Na + /Ca 2+ -exchanger, and Ca 2+ -transporter [23].…”

Section: Introductionmentioning

confidence: 99%

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IP3R Channels in Male Reproduction

Zhang

Huang

Zhou

et al. 2020

IJMS

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As a second messenger in cellular signal transduction, calcium signaling extensively participates in various physiological activities, including spermatogenesis and the regulation of sperm function. Abnormal calcium signaling is highly correlated with male infertility. Calcium signaling is mainly regulated by both extracellular calcium influx and the release of calcium stores. Inositol 1,4,5-trisphosphate receptor (IP3R) is a widely expressed channel for calcium stores. After being activated by inositol 1,4,5-trisphosphate (IP3) and calcium signaling at a lower concentration, IP3R can regulate the release of Ca2+ from stores into cytoplasm, and eventually trigger downstream events. The closure of the IP3R channel caused by a rise in intracellular calcium signals and the activation of the calcium pump jointly restores the calcium store to a normal level. In this review, we aim to discuss structural features of IP3R channels and the underlying mechanism of IP3R channel-mediated calcium signaling and further focus on the research progress of IP3R expression and function in the male reproductive system. Finally, we propose key directions and strategies for research of IP3R in spermatogenesis and the regulation of sperm function to provide more understanding of the function and mechanism of IP3R channel actions in male reproduction.

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Section: Expression Of Ip3rs In Male Reproductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

IP3R Channels in Male Reproduction

Zhang

Huang

Zhou

et al. 2020

IJMS

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“…The CatSper gene family contains CatSper 1-4 and beta and gamma [9]. CatSper genes are the key genes in male fertility expressed exclusively in the testes [10]. Hence, the aim of this study was to investigate the effects of propranolol on sperm parameters, histopathology of testes CatSper2 gene and protein effusion in adult male mice.…”

Section: Propranololmentioning

confidence: 99%

The Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Mice

Mohammadi

Beheshti

Elyasi

et al. 2020

JPRI

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The aim of this study was to investigate the effects of propranolol on sperms, histopathology of testes, and CatSper 2 gene and protein expression in adult mice. 18 adult male mice were randomly divided into control, propranolol 1 (receiving 10 mg/kg dose) and propranolol 2 group (receiving 15 mg/kg dose for 35 days). The mean amount of sperm parameters in the propranolol 1 and propranolol 2 groups was significantly lower than the control group (p<0.05). CatSper2 gene and protein expression have significantly decreased in propranolol 1 and propranolol 2 groups compared to the control group (P<0.05). Reduction of CatSper2 gene and protein expression in low dose of propranolol was more severe than high dose. In testicular tissues of the propranolol 1 group, vacuoles and necrosis in the germinal epithelium were observed, and in testicular tissues of propranolol 2 group decrease in the thickness of the germinal epithelium, some vacuoles and necrosis were observed in germinal epithelium as well as congestion in the interstitial space. The mean value of thiol and catalase enzyme in the propranolol 1 and propranolol 2 groups, and the mean value of superoxide dismutase in propranolol 1 group, were significantly different compared to the control group (P<0.05).

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The role of metal ions in the Golgi apparatus

Gao

Zhou

et al. 2022

Cell Biology International

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The Golgi apparatus is a membrane-bound organelle that functions as a central role in the secretory pathway. Since the discovery of the Golgi apparatus, its structure and function have attracted ever-increasing attention from researchers. Recently, it has been demonstrated that metal ions are necessary for the Golgi apparatus to maintain its proper structure and functions. Given that metal ions play an important role in various biological processes, their abnormal homeostasis is related to many diseases. Therefore, in this paper, we reviewed the uptake and release mechanisms of the Golgi apparatus Ca 2+ , Cu, and Zn 2+ . Furthermore, we describe the diseases associated with Golgi apparatus Ca 2+ , Cu, and Zn 2+ imbalance.

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Ca2+ signaling in mammalian spermatozoa

Cited by 58 publications

References 144 publications

IP3R Channels in Male Reproduction

IP3R Channels in Male Reproduction

The Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Mice

The role of metal ions in the Golgi apparatus

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