C825T Polymorphism of the GNB3 Gene on Valproate-Related Metabolic Abnormalities in Bipolar Disorder Patients

Abstract

The current study provides evidence that BD patients who are T allele carriers of the GNB3 C825T polymorphism have a lower risk for VPA-induced metabolic abnormalities. Further studies about the underlying mechanisms of G protein in VPA-induced metabolic abnormalities are warranted.

Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study

“…Moreover, the variant has also been found to be associated with medication-induced metabolic disturbances (Hauner et al, 2003;Peters et al, 2008;Souza et al, 2008;Wang et al, 2005). The preliminary results from our laboratory also showed the variant to be associated with valproate-induced metabolic disturbance in patients with bipolar disorder (Chang et al, , 2010a. Interestingly, previous brain imaging studies have indicated a role of the striatal dopamine system in energy homeostasis Wang et al, 2001).…”

The brain‐derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia

“… recently reported a significant association between both fatty acid desaturase 1 and 2 genes and insulin resistance, but not lipid levels, in a cross‐sectional study of 94 BPD patients. Furthermore, Chang and coworkers reported an association between the C825T polymorphism of the gene GNB3 and higher total cholesterol and triglycerides in patients with BPD treated with valproate. This outcome may reflect the polypharmacy that subjects with bipolar illness often receive.…”

Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid

“…Previous literature also reported that VPA can increase NPY , BDNF, and methylenetetrahydrofolate reductase ( MTHFR ) gene expression ( Roy et al, 2008 ; Farrelly et al, 2013 ; Almeida et al, 2014 ), which are related to appetite stimulation and energy homeostasis ( Kao and Muller, 2013 ). Thus, multiple genes are probably involved in VPA-induced weight gain; however, there is a paucity of pharmacogenetic research on VPA-induced weight gain ( Chang et al, 2010 ). Therefore, a comprehensive analysis of genetic polymorphisms that may relate to VPA-induced weight gain is necessary.…”