C60-fullerenes as Drug Delivery Carriers for Anticancer Agents: Promises and Hurdles

Kumar, Manish; Raza, Kaisar

doi:10.2174/2211738505666170301142232

Cited by 45 publications

(35 citation statements)

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“…This task can be addressed with means of nanobiotechnology. Recent progress in this field has arisen interest in a carbon nanostructure — C 60 fullerene [1] that not only exhibits unique physicochemical properties [2, 3], biological activity [4–10] and antioxidant behavior [11–14], but also possesses a significant potential to serve as a nanocarrier for drug delivery into cancer cells [15–25] (here consistently abbreviated as “C 60 ”).…”

Section: Introductionmentioning

confidence: 99%

“…The anticancer anthracycline chemotherapeutic drug Doxorubicin (here abbreviated consistently as “Dox”) is one of the first candidates for a more targeted nanodelivery due to life-threatening cardiotoxicity and other serious side effects [25, 26]. The main mechanism of Dox toxicity against cancer cells is its intercalation into nuclear DNA followed by inhibition of topoisomerase activity, DNA replication, and repair [26–28].…”

Section: Introductionmentioning

confidence: 99%

“…But Dox’s side effects on cardiomyocytes are considered to be determined by another mechanism, mainly, iron-related reactive oxygen species formation [27, 28]. The combination of C 60 antioxidant potential [2, 11, 13] and its ability for drug delivery [24, 25] makes the nanostructure very attractive for anticancer therapy.…”

Section: Introductionmentioning

confidence: 99%

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Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro

et al. 2019

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Conventional anticancer chemotherapy is limited because of severe side effects as well as a quickly evolving multidrug resistance of the tumor cells. To address this problem, we have explored a C 60 fullerene-based nanosized system as a carrier for anticancer drugs for an optimized drug delivery to leukemic cells. Here, we studied the physicochemical properties and anticancer activity of C 60 fullerene noncovalent complexes with the commonly used anticancer drug doxorubicin. C 60 -Doxorubicin complexes in a ratio 1:1 and 2:1 were characterized with UV/Vis spectrometry, dynamic light scattering, and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The obtained analytical data indicated that the 140-nm complexes were stable and could be used for biological applications. In leukemic cell lines (CCRF-CEM, Jurkat, THP1 and Molt-16), the nanocomplexes revealed ≤ 3.5 higher cytotoxic potential in comparison with the free drug in a range of nanomolar concentrations. Also, the intracellular drug’s level evidenced C 60 fullerene considerable nanocarrier function. The results of this study indicated that C 60 fullerene-based delivery nanocomplexes had a potential value for optimization of doxorubicin efficiency against leukemic cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro

et al. 2019

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“…Carbon-based NMs have shown great potential in drug delivery due to their unique characteristics of high specific surface area, good thermal conductivity, and easy surface modification. The hollow structures of fullerenes and carbon nanotubes (CNTs) could be used to carry drugs or other small molecules [73]. Large numbers of π electrons on the surface of graphene and CNTs can be used to load hydrophobic drugs [74,75].…”

Section: Carbon-based Nmsmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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“…Fullerenes are suitable for multiple functionalization steps according to their particular globular network structure [97]. They are widely used as excellent antioxidants [98], antiviral agents [99,100], drug and gene delivery systems [101][102][103] and photosensitizers for photodynamic therapy [104,105]. On the other hand, elongated design of carbon nanotubes diagnostic imaging strategies [106][107][108][109][110], drug delivery [111][112][113] and also photothermal therapy [114,115].…”

Section: Classification Of Npsmentioning

confidence: 99%

Theranostic Nanoparticles and Their Spectrum in Cancer

Onaciu¹,

Jurj²,

Moldovan³

et al. 2020

Engineered Nanomaterials - Health and Safety

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Nanoparticles offer a lot of advantageous backgrounds for many applications due to their physical, chemical and biological properties. Their different composition (metals, lipids, polymers, peptides) and shapes (spheres, rods, pyramids, flowers and so on) are influenced by the synthesis methods and functionalization procedures. However, in the medical field, researchers focus on the biocompatibility and biodegradability of the nanoparticles in their attempts for a targeted therapy in which the nanocarriers need to bypass certain biological barriers. Moreover, the increased interest in molecular imaging has brought nanoparticles in the spotlight for their applications in two distinct directions: therapy and diagnosis. Furthermore, recent advances in nanoparticle designs have introduced novel nano-objects suitable as both detection and delivery systems at the same time, thus providing theranostic applications.

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C60-fullerenes as Drug Delivery Carriers for Anticancer Agents: Promises and Hurdles

Cited by 45 publications

References 0 publications

Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro

Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Theranostic Nanoparticles and Their Spectrum in Cancer

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