C2 symmetric borneol-porphyrin hybrids: Synthesis, characterization, electronic structure and their anti-cancer behaviors

Co-Encapsulation of Hydrophilic and Hydrophobic Drugs into Human H Chain Ferritin Nanocarrier Enhances Antitumor Efficacy

“…Cancer is a serious threat to human health and is a pressing issue for researchers in the 21st century. − The lack of specificity of chemotherapy drugs has serious side effects on patients, which limits clinical treatment. , Doxorubicin (DOX) is an anthracycline antitumor drug that acts on many kinds of cancer cells. However, the limitations of DOX as a small-molecule drug, including inadequate targeting, the possibility of renal toxicity and cardiotoxicity, and other side effects, restrict its clinical applicability. ,, Ursolic acid (UA) is a pentacyclic triterpenoid compound extracted from naturally growing herbs, such as pears, apples, and loquat. , Several studies have shown that UA has little toxicity and potent anticancer benefits against various cancers, including breast cancer, lung cancer, and others. − The shortcomings of UA are also very prominent, with high hydrophobicity, hampering the clinical application. ,, Along with the antitumor effects mentioned above, UA may also be employed as a possible drug sensitizer to increase the effectiveness of chemotherapy and other drug-based cancer treatments.…”