C014 - Plasma amino acid pattern can be influenced by age and diabetes

Sacco, G. Di; Accinni, R.; Noce, Cinzia Della; F, Muratori

doi:10.1016/s0003-4266(04)95655-7

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“…They play vital roles in such processes as protein degradation and turnover, the synthesis of specific neurotransmitters, and energy metabolism. 21 , 22 The previous study showed that age and diabetes may influence plasma BCAAs, cystine and glutamine levels, 23 and BCAAs, and AAAs of young adults differ by gender and body mass index, 24 , 25 which were consistent with the results of our study. The finding of above results is of particular clinical interest and might suggest the need for further studies on the mechanisms of BCAAs and AAAs in elderly hypertension patients.…”

Section: Discussionsupporting

confidence: 92%

Association Between Blood Pressure and Branched-Chain/Aromatic Amino Acid Excretion Rate in 24-Hour Urine Samples from Elderly Hypertension Patients

Wang

Chen

et al. 2021

DMSO

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Background Recently, the association between lifestyle-related diseases and free amino acids in the blood plasma—especially branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs)—has been highlighted. However, few studies have been carried out on 24-hour urine samples. Therefore, we aimed to explore the relationships between 24-hour urinary BCAAs and AAAs excretion rate and blood pressure (BP) in elderly patients with hypertension. Methods and Results Each of the 322 elderly patients with hypertension completed an in-person questionnaire interview, underwent a physical examination, and provided a 24-hour urine specimen. We measured their BCAAs and AAAs excretion rate, and used multiple linear regression analysis with variable selection to construct models describing the relationships between their BCAAs and AAAs excretion rate and BP. After adjusted for age, gender, height, and weight, valine was inversely associated with both systolic blood pressure (SBP) ( β : −0.232, 95% CI: −0.16, −0.006) and diastolic blood pressure (DBP) ( β : −0.144, 95% CI: −0.089, −0.005). These findings were invariant even following adjustment for urine volume and drugs history, and Ile was positively associated with DBP ( β : 0.170, 95% CI: 0.001, 0.066). Conclusion The data revealed that the excretion rate of 24-hour urinary BCAAs was closely related to BP in elderly hypertension patients, and these findings will provide new insights into the association between BACC metabolism and BP.

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