Association Between Blood Pressure and Branched-Chain/Aromatic Amino Acid Excretion Rate in 24-Hour Urine Samples from Elderly Hypertension Patients

Abstract

Background Recently, the association between lifestyle-related diseases and free amino acids in the blood plasma—especially branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs)—has been highlighted. However, few studies have been carried out on 24-hour urine samples. Therefore, we aimed to explore the relationships between 24-hour urinary BCAAs and AAAs excretion rate and blood pressure (BP) in elderly patients with hypertension. Methods and Results Each of the 322 elderly patients with hypertension completed an in-person questionnaire interview, underwent a physical examination, and provided a 24-hour urine specimen. We measured their BCAAs and AAAs excretion rate, and used multiple linear regression analysis with variable selection to construct models describing the relationships between their BCAAs and AAAs excretion rate and BP. After adjusted for age, gender, height, and weight, valine was inversely associated with both systolic blood pressure (SBP) ( β : −0.232, 95% CI: −0.16, −0.006) and diastolic blood pressure (DBP) ( β : −0.144, 95% CI: −0.089, −0.005). These findings were invariant even following adjustment for urine volume and drugs history, and Ile was positively associated with DBP ( β : 0.170, 95% CI: 0.001, 0.066). Conclusion The data revealed that the excretion rate of 24-hour urinary BCAAs was closely related to BP in elderly hypertension patients, and these findings will provide new insights into the association between BACC metabolism and BP.

Duality of Branched-Chain Amino Acids in Chronic Cardiovascular Disease: Potential Biomarkers versus Active Pathophysiological Promoters

“…When measuring 24 h urine levels of BCAAs in older hypertensive patients, isoleucine was linked with diastolic blood pressure, while valine was found to be negatively correlated with both systolic and diastolic blood pressure [ 138 ]. However, Siomkajło et al [ 131 ] found significant positive associations between plasma levels and both systolic and diastolic blood pressure findings reinforced by a large-scale prospective cohort study on middle-aged men and women conducted by Flores-Guerrero et al [ 139 ].…”