C0109: Epidemiological Profile of Venous Thromboembolism in the Region of Sidi Bel Abbes, Northwest Algeria

Chalal, N.; Demmouche, Abbassia

doi:10.1016/s0049-3848(14)50194-6

Cited by 5 publications

(22 citation statements)

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“…10 On the other hand, according to Nourelhouda C in Algeria, sub serous fibroids are the most frequent (43%) in his study. 15 Authors note through present study a predominance of fibroids of the uterine body (92.1%) in comparison with isthmic (21.8%) and cervical (4.9%) fibroids, with the majority of patients (65 cases, 64.4%) having a polymyomatous uterus. This result is consistent with what found by Nourelhouda C in Algeria, who reported in his study a predominance of fibroids of the uterine body (96%) compared to isthmic (3%) and cervical fibroids (1%) and the majority of patients (167 cases or 51.70%).…”

Section: Resultssupporting

confidence: 48%

“…However only 11 patients or 3.40% of cases were operated on by total hysterectomy with adnexectomy. 15 The duration of hospitalization was short in 77.2% of cases. Ninety-one percent had a full progress.…”

Section: Resultsmentioning

confidence: 97%

“…16 For the mode of discovery, genital haemorrhage was the most frequent reason for consultation (78.2% of cases), similar to that reported by Nourelhouda in Algeria, that genital hemorrhage was the most frequent reason for consultation, that is to say 35% of all cases. 15 Laghzaoui M etalau in Morocco reported that the reason for consultation was dominated by genital hemorrhage (68.26%). 9 Elsewhere, Dia A and al in Senegal reported that the increase in the volume of the abdomen was the reason for consultation.…”

Section: Resultsmentioning

confidence: 99%

“…Nelelhouda et al in Algeria found 19.5% spontaneous abortion. 15 In the literature, the frequency of spontaneous abortions on a non-pathological uterus varies by 4% at 18%. Spontaneous abortions are more common in pregnancy-associated fibroma.…”

Section: Resultsmentioning

confidence: 99%

“…%) had a polymyomatous uterus. 15 Regarding treatment, medical treatment is dominated by symptomatic treatment especially preoperatively as antihemorrhagic (38.6%), blood transfusion (28.7%) and progestogen hormone therapy (20.8%) but no agonist GnRH were used because of its unavailability in Madagascar. In France, patients may be referred for preoperative treatment due to anemia, menometrorrhagia in accordance with GnRH agonist or Ulipristal acetate preoperative treatment, or to reduce the size of the fibroid for in present context, authors do not have a laparoscopic technique, which makes the uterine volume reduction treatments useless.…”

Section: Resultsmentioning

confidence: 99%

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Epidemiological, clinical and therapeutic profile of uterine fibroids at the Befelatanana University hospital centre of obstetric gynecology of Antananarivo, Madagascar

Rainibarijaona

Romuald

Andriamaro

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Leiomyomas or fibromyomas more commonly referred as uterine fibroids are the most common tumors of the female genital tract. They affect 20 to 25% of women in genital activity. The objective of present study is to describe the epidemiological and therapeutic profile of uterine fibroids at the UHCOBG.Methods: Retrospective and descriptive cross-sectional study of patients with uterine fibroids hospitalized in the department of gynecology of the UHCOBG between January 2015 and December 2016.Results: In total, 101 cases of uterine fibroids have been identified with a prevalence of 3.92%. The average age is 42.75±3.6 years old. The most affected age group varies from 35 to 45 years old. Thirty-eight-point six percent of the patients were pauciparous. The medical history of irregular menstrual cycle disorders was present in 17.8% of the cases. The symptomatology was dominated by menometrorrhagia (78.2%) and in 67.3% of the cases, patients had anemia. The majority of patients (64.4%) had poly-myomatous uterus which fibroid location was predominantly corporeal (92.1%), isthmic (21.8%), and three quarters of the mapping was interstitial. Complications were dominated by aseptic necrobiosis (7.9%) and conservative treatment in 68.3% of the cases. Laparotomy is the pillar of a surgical treatment. The duration of hospitalization was short in 77.2% of the cases, 91.1% had a good progress and no death was noticed during 2 years.Conclusions: This is the first operative indication of all gynecological pathologies in present UHC and proves to be a real public health problem. The development of operative laparoscopy is necessary to reduce the morbidity associated with treatment.

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Section: Resultssupporting

confidence: 48%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Epidemiological, clinical and therapeutic profile of uterine fibroids at the Befelatanana University hospital centre of obstetric gynecology of Antananarivo, Madagascar

Rainibarijaona

Romuald

Andriamaro

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Implication of the Cytochrome <i>P-450c17α</i> (<i>CYP17α</i>) Gene in the Tumor Progression of Uterine Fibroids in Senegalese Women

Diallo¹,

Daouda²,

Bineta³

et al. 2021

IJGG

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Uterine fibroids, also known as leiomyomas, uterine myomas or fibroleiomyomas, are benign, encapsulated uterine tumors consisting of smooth muscle fibers of the uterus and connective tissue, the most common in the female genital tract. They affect 20 to 25% of women of childbearing age and are 3 to 9 times more common in black women than in white women, and nearly 70% of those close to 50 years of age. Uterine myomas are a real public health problem. The cost of treating them is expensive and the only treatment deemed effective is surgery. The rapid progression of leiomyomas during the childbearing years and regression after menopause indicate that estrogen plays a key role as a growth factor for these tumors. To contribute to the knowledge of the etiological factors involved in the tumor process of uterine fibroids, the study of the Cytochrome P-450c17α gene (CYP17α), involved in the hydroxylation of estrogen, has been carried out. Our study population consisted of 57 patients with uterine fibroids. After sampling (tumour tissue and peripheral blood), molecular analysis were done (DNA extraction, PCR-sequencing). Raw data were submitted to Mutation Surveyor 5.0.1 for mutation identification and AlamutVisual 2.12 software. The pathogenicity of each non-synonymous mutation was evaluated using Polyphen-2, Mutation Taster and SIFT. After cleaning, correction and alignment of sequences with BioEdit 7.0.8.0, genetic diversity, genetic differentiation and polymorphism of the gene CYP17α in correlation with epidemiological factors were determined with DNASP 5.10.01, MEGA 7.0.14, Arlequin 3.5.3.1 and the statistical software RStudio 3.5.1. Our results showed 84 mutations characterizing a high rate of tumor tissue polymorphism but also a genetic difference between tumor and peripheral blood. The mutation c.-34T>C which is located in the 5' promoter region at 34 bp upstream of the translation initiation site was found in patients with uterine fibroids. No genetic structuring of the CYP17α gene according to clinico-pathological parameters was observed. In conclusion, the cytochrome P450 enzymes responsible for highly specific reactions in the steroid biosynthesis pathway are gaining interest as molecular targets, given their role cléF in the formation of various very potent endogenous steroid hormones. Indeed, current treatments for tumors, particularly fibroids, are mainly surgical and expensive. It is therefore essential to develop and evaluate alternatives to surgical procedures.

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Clinical, psychological and socio-professional impact of uterine myomas: case of 101 women in care at the gyneco-obstetric and pediatric hospital in Yaoundé, Cameroon

Esther¹,

Essiben²,

Pierre³

et al. 2019

OGIJ

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Uterine myomas are a real handicap for women in Africa. The aim of this study was to determine the clinical, psychological and socio-professional impact of symptomatic uterine myomas.We conducted a descriptive cross-sectional study from December 2017 to May 2018 in the gynecology department of the Yaoundé Gyneco -Obstetrics and Pediatric Hospital.We included 101 women aged on average 38.7 +/-7.6 years, living in urban areas. Female genital bleeding was found in 63.3% of women, anemia in 95%, women and infertility in 57% of women.Moderate anxiety accounted for 46.5% of patients, mental depression 70.3%, social discomfort with a negative effect on the couple in 32.7%, absenteeism at work in 70.3%, decrease in work efficiency, 64.4% of the patients.Uterine myomas have a clinical effect (bleeding and infertility), a psychological impact (anxiety, depression) and socio professional impact (decreased work efficiency and absenteeism at work) in women.

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C0109: Epidemiological Profile of Venous Thromboembolism in the Region of Sidi Bel Abbes, Northwest Algeria

Cited by 5 publications

References 0 publications

Epidemiological, clinical and therapeutic profile of uterine fibroids at the Befelatanana University hospital centre of obstetric gynecology of Antananarivo, Madagascar

Epidemiological, clinical and therapeutic profile of uterine fibroids at the Befelatanana University hospital centre of obstetric gynecology of Antananarivo, Madagascar

Implication of the Cytochrome <i>P-450c17α</i> (<i>CYP17α</i>) Gene in the Tumor Progression of Uterine Fibroids in Senegalese Women

Clinical, psychological and socio-professional impact of uterine myomas: case of 101 women in care at the gyneco-obstetric and pediatric hospital in Yaoundé, Cameroon

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C0109: Epidemiological Profile of Venous Thromboembolism in the Region of Sidi Bel Abbes, Northwest Algeria

Cited by 5 publications

References 0 publications

Epidemiological, clinical and therapeutic profile of uterine fibroids at the Befelatanana University hospital centre of obstetric gynecology of Antananarivo, Madagascar

Epidemiological, clinical and therapeutic profile of uterine fibroids at the Befelatanana University hospital centre of obstetric gynecology of Antananarivo, Madagascar

Implication of the Cytochrome &lt;i&gt;P-450c17α&lt;/i&gt; (&lt;i&gt;CYP17α&lt;/i&gt;) Gene in the Tumor Progression of Uterine Fibroids in Senegalese Women

Clinical, psychological and socio-professional impact of uterine myomas: case of 101 women in care at the gyneco-obstetric and pediatric hospital in Yaoundé, Cameroon

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Implication of the Cytochrome <i>P-450c17α</i> (<i>CYP17α</i>) Gene in the Tumor Progression of Uterine Fibroids in Senegalese Women