“…Calcium signals induce vascular endothelial cells or smooth muscle cells to contract microfilaments and microtubules, causing cell migration, sprouting, and growth of blood vessels, which effectively regulates blood vessel diameter and contributes to the remodeling of heart function [36] . Inflammatory factors such as IL-1 and IL-8 cause migration of vascular endothelial cells, angiogenesis, and typical inflammatory reactions [37] , [38] . VEGF is a very clear cytokine that promotes blood vessel growth.…”