C-reactive Protein to Albumin Ratio among Patients Admitted to Intensive Care Unit of a Tertiary Care Hospital: A Descriptive Crosssectional Study

Gyawali, Prakash C.; Shrestha, Himal; Pant, Vivek; Risal, Prabodh; Gautam, Swotantra

doi:10.31729/jnma.7047

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Results of the present study suggested that CAR was associated with the prognosis in patients treated in ICU. Accordingly, in a recent study by Gyawali et al, it has been suggested that CAR could be useful in determining patients with a high risk of sepsis development (12). In contrast, CAR levels of survivals and nonsurvivals were not statistically different in ICU subjects with sepsis (13).…”

Section: U N C O R R E C T E Dmentioning

confidence: 96%

C-reactive protein-to-serum albumin ratio as a marker of prognosis in adult intensive care population

Karagöz¹,

Özer²,

İtal³

et al. 2023

BLL

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BACKGROUND: Patients in intensive care unit (ICU) require close follow up and clinical attention due to variability in the course of their underlying morbidities. The estimation of prognosis in these subjects has an utmost importance. Recent studies showed that C-reactive protein-to-serum albumin ratio (CAR) could be a reliable marker of infl ammation in certain conditions. We aimed to compare CAR levels of deceased patients to those in survived subjects treated in ICU. PATIENTS AND METHODS: We retrospectively analyzed the data of adult patients. CAR was simply calculated by dividing the levels of CRP by those of serum albumin. Patients were grouped either as deceased or survived according to the prognosis. The data of the survived and deceased ICU subjects were compared. RESULTS: A total of 208 subjects, 101 deceased and 107 survived, were enrolled in the study. Median CAR levels of the deceased and survived subjects were 49.5 (3-153 %) and 11 (0.2-119 %), respectively (p < 0.001). CAR was signifi cantly correlated with PDW (r = 0.24; p < 0.001) and serum creatinine (r = 0.27; p < 0.001) levels. In ROC analysis, CAR values higher than 30.2 % have 72 % sensitivity and 70 % specifi city in predicting mortality in ICU population (AUC: 0.74; p < 0.001; 95% CI: 0.67-0.81). CONCLUSIONS: We suggest that CAR levels of the subjects in ICU should be evaluated during medical care. Increased CAR levels should alert physicians for a worse outcome in those subjects (Tab. 1, Fig. 1, Ref. 21).

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Section: U N C O R R E C T E Dmentioning

confidence: 96%

C-reactive protein-to-serum albumin ratio as a marker of prognosis in adult intensive care population

Karagöz¹,

Özer²,

İtal³

et al. 2023

BLL

View full text Add to dashboard Cite

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Vai trò của CRP và albumin huyết thanh trong chẩn đoán nhiễm khuẩn sơ sinh sớm

Trần

2023

jcmhch

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TÓM TẮT Đặt vấn đề: Nhiễm khuẩn sơ sinh sớm là bệnh lý còn gặp rất nhiều khó khăn trong chẩn đoán, vì các triệu chứng của bệnh đa dạng, ít đặc hiệu, có thể gặp trong các tình huống không nhiễm khuẩn dẫn đến điều trị kháng sinh không cần thiết. CRP và albumin huyết thanh là các chỉ điểm cho thấy sự hiện diện và mức độ nghiêm trọng của nhiễm khuẩn huyết ở trẻ sơ sinh. Đề tài này nhằm tìm hiểu mối liên quan của CRP và albumin huyết thanh với mức độ nhiễm khuẩn sơ sinh sớm. Đối tượng, phương pháp: Trẻ sơ sinh < 72 giờ tuổi nghi ngờ NKSSS có ít nhất 1 triệu chứng lâm sàng theo tiêu chuẩn chẩn đoán NKSS của Bộ Y Tế năm 2015. Xác định mức độ NKSS và thực hiện xét nghiệm CRP và albumin huyết thanh tại thời điểm chẩn đoán. Kết quả: 90 bệnh nhân nhiễm khuẩn sơ sinh sớm, trong đó 18 trường hợp NKH SS. Biến đổi nồng độ albumin huyết thanh chiếm tỷ lệ cao nhất với 53,3 %, tiếp theo là CRP với tỷ lệ 37,8%. Tỷ lệ trẻ tăng CRP ở nhóm NKH SS (100%) cao hơn nhóm NKSS (22,2%) (p < 0,05). Tỷ lệ trẻ giảm albumin huyết thanh ở nhóm NKH SS (77,8%) cao hơn nhóm NKSS (47,2%) (p < 0,05). Trung vị CAR ở nhóm NKH SS (0,62 ) cao hơn nhóm NKSS (0,11) (p < 0,05). Kết luận: Sự kết hợp giữa CRP và albumin huyết thanh là một yếu tố dự báo độc lập cho sự hiện diện và mức độ nghiêm trọng của nhiễm khuẩn huyết ở trẻ sơ sinh. x ABSTRACT RELATIONSHIP BETWEEN SERUM CRP, ALBUMIN LEVELS AND EARLY-ONSET INFECTION IN NEONATES Background: Early - Onset Infection in Neonates (EOIN) is a disease with many difficulties in diagnosis, because symptoms of aforementioned disease are diverse, less specific, and can be encountered in non-infectious situations, leading to unnecessary antibiotic treatments. CRP and serum albumin are indicators of the presence and severity of neonatal sepsis. This study aims to understand the between CRP and serum albumin and the level of EOIN. Methods: Newborns < 72 hours of age with suspected EOIN have at least 1 clinical symptom according to diagnostic criteria for EOIN of the Ministry of Health 2015. Evaluation of the EOIN level and taking CRP and serum albumin testing at the time of diagnosis. Results: 90 patients with EOIN, including 18 cases of early-onset neonatal sepsis (EONS). Changes in serum albumin concentration accounted for the highest rate at 53.3%, followed by CRP at 37.8%. The rate of children with increased CRP in the EONS group (100%) was higher than the EOIN group (22.2%) (p < 0.05). The proportion of children with decreased serum albumin in the EONS group (77.8%) was higher than the EOIN group (47.2%) (p < 0.05). The median CAR in the EONS group (0.62) was higher than the EOIN group (0.11) (p < 0.05). Conclusion: The combination between CRP and serum albumin is an independent predictor of the presence and severity of early-onset neonatal sepsis (EONS).

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C-reactive Protein to Albumin Ratio among Patients Admitted to Intensive Care Unit of a Tertiary Care Hospital: A Descriptive Crosssectional Study

Cited by 2 publications

References 21 publications

C-reactive protein-to-serum albumin ratio as a marker of prognosis in adult intensive care population

C-reactive protein-to-serum albumin ratio as a marker of prognosis in adult intensive care population

Vai trò của CRP và albumin huyết thanh trong chẩn đoán nhiễm khuẩn sơ sinh sớm

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