C‐reactive protein may be a marker of bacterial translocation in experimental intestinal obstruction

Çevikel, Mehmet Hakan; Özgün, Hedef; Boylu, Şükrü; Demirkiran, Ahmet Ender; Aydın, Neriman; Sari, Cavide; Erkuş, Muhan

doi:10.1111/j.1445-1433.2003.02681.x

Cited by 22 publications

(25 citation statements)

References 20 publications

(19 reference statements)

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“…The ability of its cutoff level to define BT with high sensitivity, specificity and accuracy was associated with a statistically significant predictor value in accordance with Cevikel et al 1 making CRP a reliable test to detect BT during I.O.…”

Section: Discussionsupporting

confidence: 61%

“…colonizing factor thus supporting lymphatic route for BT. Furthermore, the obligate anaerobic organisms isolates detection as reported by Boedeker 31 ; O'Boyle et al 32 and Cevikel et al 1 define the colonization resistance failure in the ischemic intestinal obstruction. So bacterial overgrowth, bacterial virulence and wall integrity (structure and function) work together.…”

Section: Discussionmentioning

confidence: 99%

“…Biochemical study (1) Ileal loop oxidant and antioxidant activity, were studied (2) Serum CRP and IL-10 levels were assayed.…”

Section: Laboratory Studiesmentioning

confidence: 99%

“…Intestinal obstruction (IO) is a common lethal abdominal emergency resulting in high mortality, mostly due to multiorgan dysfunction syndrome (MODS) 1 , significantly bacterial translocation (BT) together with septic peritonitis are the major contributors of MODS in IO 2 .…”

Section: Introductionmentioning

confidence: 99%

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Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

et al. 2009

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Background: Bacterial translocation occurs in preseptic conditions such as intestinal obstruction through unclear mechanism. The C-reactive protein is an acute phase reactant and a marker of ischemia. Methods: 45 albino male rats were divided into 3 groups each 15 rats. GI control, GII simple intestinal-obstruction and GIII strangulated obstruction. Outcome measures were: (1) Bacteriologic count and typing for intestinal contents, intestinal wall, liver, mesenteric lymph nodes and blood (cardiac and portal) (2) Histopathologic: mucosal injury score, inflammatory cell infiltrate in the wall, MLN, liver, (3) Biochemical: serum CRP, IL-10, mucosal stress pattern (glutathione peroxidase-malonyldialdhyde tissue levels). Results: (1) Intestinal obstruction associates with BT precursors (Bact-overgrowth, mucosal-acidosis, immuno-incomptence), (2) Bacterial translocation (frequency and density) was found higher in strangulated I.O, that was mainly enteric (aerobic and anaerobic) and mostly E.coli, (3) The pathogen commonality supports the gut origin hypothesis but the systemic inflammatory response goes with the cytokine generating one. (4) The CRP median values for GI, II, III were 0.5, 6.9, 8.5 mg/L, for BT +ve 8 mg/L and 0.75 mg/L for BT -ve rats. Conclusion: Bacterial translocation occurs bi-directional (systemic-portal) in intestinal obstruction and the resultant inflammatory response pathogenesis is mostly 3 hit model. The CRP is a non selective marker of suspected I.O cases. However, it is a reliable marker of BT, BT density and vascular compromise during I.O. Key words: Intestinal Obstruction. Ischemia. Bacterial Translocation. Rats. RESUMO Objetivo:Translocação bacteriana ocorre em condições pré-sépticas como na obstrução intestinal por mecanismo não esclarecido. A proteína C-reativa é um marcador de ischemia em fase aguda. A proposição é investigar os possíveis efeitos da obstrução intestinal no equilíbrio ecológico microbiano. Métodos: 45 ratos machos albinos foram distribuídos em três grupos de 15 ratos. GI controle, GII obstrução intestinal simples e GIII obstrução estrangulada. As medidas adotadas foram: (1) Contagem bacteriológica do conteúdo intestinal, parede intestinal, fígado, linfonodos mesentéricos e sangue (coração e portal) (2) Avaliação histopatológica da lesão da mucosa, infiltrado celular inflamatório da parede, linfonodos mesentéricos, fígado, (3) Avaliação bioquímica. Resultados: (1) Obstrução intestinal está associada a precursora translocação bacteriana (crescimento bacteriano, acidose da mucosa, imuno-incompetência), (2) Translocação bacteriana (freqüência e densidade) foi maior na obstrução intestinal estrangulada, principalmente entérica (aeróbios e anaeróbios), sobretudo E.coli, (3) A ocorrência comum é de origem intestinal. Conclusão: A translocação bacteriana na obstrução intestinal é bi-direcional (sistêmica e portal) A proteina C-reativa não é um marcador seletivo na suspeita de obstrução intestinal. Contudo é marcador confiável da translocação bacteriana, na densidade e com...

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

“…Biochemical study (1) Ileal loop oxidant and antioxidant activity, were studied (2) Serum CRP and IL-10 levels were assayed.…”

Section: Laboratory Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

et al. 2009

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“…Bacterial translocation occurs in preseptic conditions such as intestinal obstruction, and procalsitonin (PCT) may be a marker of this condition (3). C-reactive protein (CRP) is an acute phase reactant and a marker of ischemia and bacterial translocation (3,4). On the other hand, blood fibrinogen level elevates in many ischemic events of the body including intestinal ischemia (5).…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin, C-Reactive Protein, and Fibrinogen Levels in Cases With Mechanic Bowel Obstruction and Their Changing in Relation With the Duration of Obstruction: An Experimental Study

Güzel

Kahramanca

Kaya

et al. 2017

International Surgery

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Abstract:The need and timing of surgical intervention in patients with adhesive bowel obstruction is a dilemma. We aimed to investigate the role of three acute-phase reactants, namely procalcitonin (PCT), fibrinogen and C-reactive protein (CRP) in this clinical condition We chose a rat model whose mechanical bowel obstruction was created with caecum ligation. There were two study groups and one control group. Each group contained ten subjects. The study groups had and six-hour obstruction samples. Blood PCT, fibrinogen and CRP levels were measured before and after the surgical procedure. These parameters were compared between the groups and they were also evaluated with the degree of histopathological changes occurred in terminal ileal tissue samples. Compared with the control group, PCT measurements showed a mild decrease in the early phase of obstruction but a significant elevation in the late phase (p: 0,977 and p: 0,001). Unlike PCT, fibrinogen levels increased at first but decreased later (p: 0,978 and p: 0,326). We observed an increase in CRP levels parallel to the prolonged duration of obstruction (p: 0,987 and p: 0,134). With regard to mucosal injury, PCT levels increased at first, and then decreased (p: 0,003). On the other hand, fibrinogen and CRP levels decreased at first, and then increased (p: 0,139 and p: 0,102). The acute-phase reactants PCT, fibrinogen and CRP associated with the duration of obstruction may help to determine the time of surgical intervention in patients with adhesive mechanical bowel obstruction.

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A computed tomography-based radiomic model for the prediction of strangulation risk in patients with acute intestinal obstruction

Wang

Liu

et al. 2024

Intelligent Medicine

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C‐reactive protein may be a marker of bacterial translocation in experimental intestinal obstruction

Abstract: CRP levels increase with the severity of bacterial translocation in acute intestinal obstruction but do not permit discrimination between simple and strangulated intestinal obstruction.

Cited by 22 publications

References 20 publications

Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

Bacterial translocation in an experimental intestinal obstruction model: C-reactive protein reliability?

Procalcitonin, C-Reactive Protein, and Fibrinogen Levels in Cases With Mechanic Bowel Obstruction and Their Changing in Relation With the Duration of Obstruction: An Experimental Study

A computed tomography-based radiomic model for the prediction of strangulation risk in patients with acute intestinal obstruction

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