C-Reactive Protein, Lipid-soluble Micronutrients, and Survival in Colorectal Cancer Patients

Cooney, Robert V.; Chai, Weiwen; Franke, Adrian A.; Wilkens, Lynne R.; Kolonel, Laurence N.; Marchand, Loı̈c Le

doi:10.1158/1055-9965.epi-13-0199

Cited by 32 publications

(40 citation statements)

References 46 publications

(50 reference statements)

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“…Our finding of better survival among Japanese Americans than whites agrees with previous reports from Hawaii [28] and Asians within SEER registries [29]. The protective effects of excess BMI in Latinos, African Americans, and Native Hawaiians may be the result of chance or a number of possible biases [10].…”

Section: Discussionsupporting

confidence: 90%

“…The fact that CRC survival showed little consistent association with BMI status is surprising in light of the relatively consistent evidence for adverse outcomes in overweight and obese breast cancer survivors [37], the higher risk to develop CRC in obese individuals [7, 8], and the hypothesized influence of chronic inflammation on CRC survival [28, 38]. It is possible that the adverse effects of excess body weight are obscured because not all obese patients may be in an inflammatory state and detrimental effects of body weight may only occur in patients with chronic inflammation as suggested by a report from Hawaii [28].…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that the adverse effects of excess body weight are obscured because not all obese patients may be in an inflammatory state and detrimental effects of body weight may only occur in patients with chronic inflammation as suggested by a report from Hawaii [28]. Participants in the highest quintile of C-reactive protein (CRP) experienced approximately 50% lower survival, but excess BMI was not associated with survival [28]. Also, signs of systemic inflammatory response were independent predictors of poor outcome in patients receiving adjuvant 5-FU-based chemotherapy [39].…”

Section: Discussionmentioning

confidence: 99%

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Excess body weight and colorectal cancer survival: the multiethnic cohort

Maskarinec

Harmon

Little

et al. 2015

Cancer Causes Control

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Purpose Excess body weight is a risk factor for colorectal cancer (CRC) and may also adversely affect survival in CRC patients. Methods This study examined the relation of body mass index (BMI), which was self-reported at cohort entry and after 5.7±0.8 years, with CRC-specific and all-cause survival among 4,204 incident cases of invasive CRC in the Multiethnic Cohort (MEC). Cox regression analysis with age as time metric and BMI as time-varying exposure was applied to estimate hazard ratios (HR) and 95% confidence intervals (CIs) while adjusting for relevant covariates. Results Over 6.0±4.7 years of follow-up, 1,976 all-cause and 1,095 CRC-specific deaths were recorded. The mean time interval between cohort entry and diagnosis was 7.6±4.7 years. No association with CRC-specific survival was detected in men (HR5units=0.94; 95%CI 0.84–1.04) or women (HR5units=0.98; 95%CI 0.89–1.08). In men, all-cause survival also showed no relation with BMI (HR5unit=0.97; 95%CI 0.90–1.06), whereas it was reduced in women (HR5units=1.10; 95%CI 1.03–1.18). Interactions of BMI with ethnicity were only significant for obesity. Obese Latino and overweight Native Hawaiian men as well as overweight African American women, experienced significantly better CRC-specific survival than whites. Overweight Japanese men and African American women had better all-cause survival and obese Latino women had the lowest all-cause survival (HRobese=1.74; 95%CI 1.08–2.80). Conclusions This analysis detected little evidence for an adverse effect of excess body weight on CRC-specific survival, but all-cause survival was reduced in women. These findings suggest that adiposity may be less important for CRC survival than as an etiologic factor.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Excess body weight and colorectal cancer survival: the multiethnic cohort

Maskarinec

Harmon

Little

et al. 2015

Cancer Causes Control

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“…Inflammation may also involve in the link between sedentary behaviors and colorectal cancer progression. C-reactive protein, a general marker of inflammation was recently observed to be positively associated with sedentary time (15, 38) and colorectal cancer-specific mortality (39). …”

Section: Discussionmentioning

confidence: 99%

Television watching and colorectal cancer survival in men

Cao

Meyerhardt

Chan

et al. 2015

Cancer Causes Control

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Purpose To assess the association between pre- and postdiagnostic time spent sitting watching TV as well as other sedentary behaviors (other sitting at home and at work/driving) and mortality from colorectal cancer or other causes, and overall mortality. Methods We followed stage I-III colorectal cancer patients from the Health Professionals Follow-up Study (1986–2010). Cox models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results 926 and 714 patients were included in the analysis of pre- and postdiagnostic TV watching respectively, and 471 and 325 died during follow-up. Prolonged prediagnostic TV viewing was associated with increased risk of colorectal cancer-specific mortality independent of leisure-time physical activity. The HRs (95% CIs) for 0–6, 7–13,14–20 and ≥21 h/wk were 1.00 (referent), 0.84 (0.56–1.25), 1.15 (0.75–1.78), 2.13 (1.31–3.45) (Ptrend=0.01). The association was observed primarily among overweight and obese individuals. Prediagnostic TV watching was also associated with overall mortality within 5 years of diagnosis, largely due to the association with colorectal cancer mortality. Other prediagnostic sitting at home or at work/driving was not associated with mortality. Postdiagnostic TV viewing was associated with non-significant increased risk of colorectal cancer-specific mortality (HR for ≥21 vs 0–6 h/wk=1.45; 95% CI 0.73–2.87) adjusting for TV viewing before diagnosis. Conclusion Prolonged prediagnostic TV watching is associated with higher colorectal cancer-specific mortality independent of leisure-time physical activity among colorectal cancer patients.

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“…The C-reactive protein (CRP) is a commonly used marker for low grade inflammation, and has been linked to increased risk of cancer, cardiovascular diseases and mortality (Balkwill & Mantovani, 2001; Cesari et al, 2003; Cooney et al, 2013; Danesh et al, 1998). The primary role of vitamin D is to maintain calcium homoeostasis and bone health (Deeb, Trump, & Johnson, 2007).…”

Section: Introductionmentioning

confidence: 99%

Association of individual and community factors with C-reactive protein and 25-hydroxyvitamin D: Evidence from the National Health and Nutrition Examination Survey (NHANES)

Chai

Fan

Wen

2016

SSM - Population Health

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Many individual and community/neighborhood factors may contribute to inflammation and vitamin D deficiency leading to the development of chronic diseases. This study examined the associations of serum C-reactive protein (CRP) and 25-hydroxyvitamin D [25(OH)D] levels with individual and community/neighborhood (tract-level or county-level) factors using a nationally representative sample from 2001–2006 National Health and Nutrition Examination Survey (NHANES). Data from the 2001–2006 waves of the continuous NHANES was merged with the 2000 census and other neighborhood data sources constructed using geographic information system. Associations between multilevel factors and biomarker levels were assessed using multilevel random-intercept regression models. 6643 participants aged 19–65 (3402 men and 3241 women) were included in the analysis. Family income-to-needs ratio was inversely associated with CRP (P=0.002) and positively associated with 25(OH)D levels (P=0.0003). County crime rates were positively associated with CRP (P=0.007) and inversely associated with 25(OH)D levels (P=0.0002). The associations with income-to-needs ratio were significant in men [CRP, P=0.005; 25(OH)D, P=0.005] but not in women. For county crime rates, the association was only significant in women for CRP (P=0.004) and was significant in both men (P=0.01) and women (P=0.001) for 25(OH)D. Additionally, overall CRP was positively associated with age (P<0.0001), female sex (P<0.0001), Hispanic race/ethnicity (P=0.0001), current smokers (P<0.0001), body mass index (BMI, P<0.0001), and participants who were US-born (P=0.02). Non-Hispanic black (P<0.0001) and Hispanic race/ethnicity (P<0.0001), current smoker (P=0.047), and higher BMI (P<0.0001) were associated with lower serum 25(OH)D levels. No significant associations were observed between other community/neighborhood variables and serum CRP and 25(OH)D levels. The current results suggest that family income-to-needs ratio and county crime rate may be important contributors to chronic inflammation and vitamin D status.

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C-Reactive Protein, Lipid-soluble Micronutrients, and Survival in Colorectal Cancer Patients

Cited by 32 publications

References 46 publications

Excess body weight and colorectal cancer survival: the multiethnic cohort

Excess body weight and colorectal cancer survival: the multiethnic cohort

Television watching and colorectal cancer survival in men

Association of individual and community factors with C-reactive protein and 25-hydroxyvitamin D: Evidence from the National Health and Nutrition Examination Survey (NHANES)

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