C-reactive protein levels in patients undergoing controlled ovarian hyperstimulation for IVF cycle

Orvieto, Raoul; Chen, Roni; Ashkenazi, Jacob; Ben-Haroush, Avi; Bar, Jacob; Fisch, Benjamin

doi:10.1093/humrep/deh089

Cited by 49 publications

(18 citation statements)

References 10 publications

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“…In the present study, we have failed to observe any statistically significant correlation between day 3 hs-CRP and IVF cycle outcomes or clinical pregnancy. Our findings concur with other studies [19,20] which found no correlation between circulating levels of hs-CRP prior to ovarian stimulation with gonadotrophins and IVF outcome. In contrast, Levin and colleagues [17], who measured hs-CRP at different time points, noted that hs-CRP concentrations on day 3 correlated with IVF treatment failure.…”

Section: Discussionsupporting

confidence: 93%

“…Levin and colleagues [17] were amongst the first to report significantly higher hs-CRP levels in women admitted to the hospital with a diagnosis of ovarian hyperstimulation syndrome. These and other authors [19] speculated that the inflammatory process results from stimulation treatment and may be responsible for the molecular mechanisms leading to the various degrees of the syndrome. Almagor and colleagues [18] took serial measurements of CRP during the IVF cycle and found that the levels increased 1 week after oocyte retrieval.…”

Section: Discussionmentioning

confidence: 90%

“…The available studies present considerable differences in design, subjects and methods, reaching contradictory results [17][18][19][20]. Gonadotrophin hyperstimulation, oocyte retrieval and blastocyst-endometrium interaction (i.e., early stages of implantation) are thought to induce a temporary inflammatory state as evidenced by a rise in CRP levels and inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Levin and colleagues [17] reported that higher CRP levels during IVF stimulation were associated with failure of conception. Conversely, other authors [19,20] found that CRP measurements were not a predictive marker of IVF success.…”

Section: Introductionmentioning

confidence: 92%

“…As yet, a handful of studies have investigated CRP levels during assisted conception, making it difficult to know the expected normal levels in different subgroups of patients [17][18][19][20]. Levin and colleagues [17] reported that higher CRP levels during IVF stimulation were associated with failure of conception.…”

Section: Introductionmentioning

confidence: 99%

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Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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Purpose To assess the relationship between low-grade inflammation, measured as basal high sensitivity (hs)-CRP, and IVF outcome. Methods We recruited a total of 220 women undergoing infertility work up prior to IVF. Patients were selected for a BMI<30 kg/m 2 with an upper age limit of 40 years. Serum hs-CRP levels were measured on day 3 of a spontaneous menstrual cycle preceding ovarian stimulation. A sensitive two-site ELISA was used for analysis. Dose of gonadotrophins required, follicles days 8 and 10, number of oocytes collected, number of oocytes fertilised and pregnancy outcome were recorded. Results Median hs-CRP was 1.08 mg/L (0.43-3.00 mg/L). The hs-CRP was significantly related to BMI (r=0.386, P<.001) but not to age and smoking habit. There were no significant relationships between basal hs-CRP and any of the measured IVF outcomes. Conclusions These findings demonstrate that serum hs-CRP concentration is not a predictive marker of cycle or pregnancy outcome in women undergoing IVF treatment.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Robinson

Pemberton

Laing

et al. 2008

J Assist Reprod Genet

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Diosmin for the prevention of ovarian hyperstimulation syndrome

Zhu

Liu

et al. 2020

Intl J Gynecology & Obste

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Objective:To evaluate the effect of oral diosmin on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) and explore the value of diosmin in preventing and treating OHSS. Method:A retrospective study of women attending a reproductive center in Guangzhou, China, between September and December 2016. The inclusion criterion was previous cancellation of embryo transfer after oocyte retrieval during IVF owing to a high risk of OHSS. The women were divided into two groups depending on whether they received oral diosmin (1000 mg twice daily for 10 days) after oocyte retrieval (diosmin group) or not (control group). Apart from diosmin, both groups underwent the same treatment.Baseline information and data related to OHSS were compared. Results:Overall, 146 women were included: 74 in the diosmin group and 72 in the control group. The incidence of moderate-to-severe OHSS in the diosmin and control groups was 5/74 (6.2%) and 14/72 (13.4%), respectively (P=0.027). The control group included four cases of paracentesis due to ascites; there were no cases of paracentesis or severe OHSS in the diosmin group. Conclusion:Oral administration of diosmin effectively reduced both the incidence of moderate-to-severe OHSS and the severity of OHSS among high-risk women.

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Inflammation, Reproduction, and the Goldilocks Principle

Clancy

2012

Building Babies

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C-reactive protein levels in patients undergoing controlled ovarian hyperstimulation for IVF cycle

Abstract: The significant increase in serum CRP levels during COH, especially after HCG administration, suggests that COH potentiates a state of systemic inflammation.

Cited by 49 publications

References 10 publications

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Low grade inflammation, as evidenced by basal high sensitivity CRP, is not correlated to outcome measures in IVF

Diosmin for the prevention of ovarian hyperstimulation syndrome

Inflammation, Reproduction, and the Goldilocks Principle

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