C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese: The Circulatory Risk in Communities Study (CIRCS)

Chei, Choy‐Lye; Yamagishi, Kazumasa; Ikeda, Ai; Noda, Hiroyuki; Maruyama, Minako; Cui, Renzhe; Imano, Hironori; Kiyama, Masahiko; Kitamura, Akihiko; Asada, Takashi; Iso, Hiroyasu

doi:10.1016/j.atherosclerosis.2014.07.036

Cited by 14 publications

(12 citation statements)

References 43 publications

(42 reference statements)

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“…Previous epidemiological studies that assessed the association between CRP concentration and cognitive function in general populations were mainly from Western countries, and only a few such studies have been conducted in East Asian populations. Regarding the latter, two studies targeted Chinese populations and one targeted a Japanese population [ 15 , 16 , 17 ]. The first study was a hospital-based case-control study which found higher CRP concentrations in the cognitive impairment (case) group [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The second study, a prospective study of patients with mild cognitive impairment, reported that a higher CRP concentration at baseline increased the risk of dementia at 2 years of follow-up [ 16 ]. The third study was a case-control study of residents from two rural communities of Japan that found an association between higher CRP concentrations and an increased risk of disabling dementia (case), however only in individuals with a history of stroke [ 17 ]. In that study [ 17 ], the participants with disabling dementia were selected based on information from the national long-term care insurance program, and so no information was available regarding cognitive function, making cross-study comparisons difficult.…”

Section: Discussionmentioning

confidence: 99%

“…The third study was a case-control study of residents from two rural communities of Japan that found an association between higher CRP concentrations and an increased risk of disabling dementia (case), however only in individuals with a history of stroke [ 17 ]. In that study [ 17 ], the participants with disabling dementia were selected based on information from the national long-term care insurance program, and so no information was available regarding cognitive function, making cross-study comparisons difficult. In the present study, we found a clear association between CRP concentration and cognitive decline using the MMSE, an objective measure of cognitive status.…”

Section: Discussionmentioning

confidence: 99%

“…Although some studies have reported an association between increased CRP concentration and a modest increase in the risk of dementia [ 13 ] or cognitive decline [ 14 ], this association is inconclusive. Moreover, among studies that have reported on this association, population-based epidemiological studies using East Asian populations are limited [ 15 , 16 , 17 , 18 ]. CRP concentration varies widely by ethnic background.…”

Section: Introductionmentioning

confidence: 99%

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Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Watanabe¹,

Kitamura²,

Nakamura³

et al. 2016

Dement Geriatr Cogn Disord Extra

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Background/Aims: We aimed to determine whether the concentration of serum C-reactive protein (CRP) is associated with cognitive function in an adult Japanese population. Methods: Participants of this cross-sectional study were from a subgroup of the Project in Sado for Total Health (PROST; n = 454; mean age, 70.5 years). The cognitive state was evaluated using the Mini-Mental State Examination (MMSE), and those with an MMSE score <24 were considered ‘cognitively declined'. Concentrations of serum high-sensitivity CRP were measured. Multiple logistic regression analysis was used to calculate odds ratios (ORs) for cognitive decline, adjusting for the covariates of age, sex, BMI, disease history, and APOE allele. Results: Of the 454 participants, 94 (20.7%) were cognitively declined. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1.29 (95% CI 0.61-2.75) for the second, 1.78 (95% CI 0.82-3.86) for the third, and 3.05 (95% CI 1.45-6.42) for the highest (fourth) quartiles (p for trend = 0.018). When data were stratified by sex, the association between CRP concentration and cognitive decline was observed only in women. Conclusion: Our findings suggest an association between higher CRP concentration and lower cognitive function. Chronic inflammation may affect cognitive function in adults, in particular women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Watanabe¹,

Kitamura²,

Nakamura³

et al. 2016

Dement Geriatr Cogn Disord Extra

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“…The criteria of disabling dementia were the same as those of our previous studies 21, 24–26) . Incidence of disabling dementia was defined as individuals who received cares for disability including dementia-related symptoms and/or behavioral disturbance and who were ranked as II or greater on the standardized physicians' classification in Long-Term Care Insurance in Japan.…”

Section: Methodsmentioning

confidence: 99%

Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)

Jinnouchi

Kitamura

Yamagishi

et al. 2017

J Atheroscler Thromb

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Aim: To investigate the association of retinal vascular changes with a risk of dementia in longitudinal population-based study.Methods: We performed a nested case-control study of 3,718 persons, aged 40–89 years, enrolled between 1983 and 2004. Retinal vascular changes were observed in 351 cases with disabling dementia (average period before the onset, 11.2 years) and in 702 controls matched for sex, age, and baseline year. Incidence of disabling dementia was defined as individuals who received cares for disabilities including dementia-related symptoms and/or behavioral disturbance. Conditional logistic regression analysis was used to calculate odds ratio (OR) and multivariable adjusted OR (Models 1 and 2) for incidence of disabling dementia according to each retinal vascular change. Regarding confounding variables, Model 1 included overweight status, hypertension, hyperglycemia, dyslipidemia, and smoking status, whereas Model 2 also included incidence of stroke prior to disabling dementia for further analysis.Results: The proportion of cases (controls) with retinal vascular changes was 23.1 (15.7)% for generalized arteriolar narrowing, 7.7 (7.5)% for focal arteriolar narrowing, 15.7 (11.8)% for arteriovenous nicking, 10.5 (9.3)% for increased arteriolar wall reflex, and 11.4 (9.8)% for any other retinopathy. Generalized arteriolar narrowing was associated with an increased risk of disabling dementia: crude OR, 1.66 (95% confidence interval, 1.19–2.31); Model 1: OR, 1.58 (1.12–2.23); Model 2: OR, 1.48 (1.04–2.10). The number of retinal abnormalities was associated in a dose–response manner with the risk.Conclusion: Generalized arteriolar narrowing and total number of retinal abnormalities may be useful markers for identifying persons at higher risks of disabling dementia.

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C-Reactive Protein Predicts Incidence of Dementia in an Elderly Asian Community Cohort

Hsu

Pan

Yip

et al. 2017

Journal of the American Medical Directors Association

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C-reactive protein levels and risk of disabling dementia with and without stroke in Japanese: The Circulatory Risk in Communities Study (CIRCS)

Cited by 14 publications

References 43 publications

Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS)

C-Reactive Protein Predicts Incidence of Dementia in an Elderly Asian Community Cohort

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