Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Watanabe, Yumi; Kitamura, Kaori; Nakamura, Kazutoshi; Sanpei, Kazuhiro; Wakasugi, Minako; Yokoseki, Akio; Onodera, Osamu; Ikeuchi, Takeshi; Kuwano, Ryozo; Momotsu, Takeshi; Narita, Ichiei; Endo, Naoto

doi:10.1159/000442585

Cited by 51 publications

(38 citation statements)

References 64 publications

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“…Our findings correlate with other similar studies (21). Level of CRP in our study did not correlate significantly with global cognitive function unlike previous findings (22)(23)(24)(25). Our study showed that elevated PTH levels and severity of secondary hyperparathyroidism statistically significantly correlates with space and time orientation disorders.…”

Section: Discussionsupporting

confidence: 80%

Analysis of Risk Factors for Development of Cognitive Disorders in Maintenance Hemodialysis Patients – Pilot Study

Todorović

Milovanovic

Drašković

et al. 2017

Serbian Journal of Experimental and Clinical Research

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Section: Discussionsupporting

confidence: 80%

Analysis of Risk Factors for Development of Cognitive Disorders in Maintenance Hemodialysis Patients – Pilot Study

Todorović

Milovanovic

Drašković

et al. 2017

Serbian Journal of Experimental and Clinical Research

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“…Several reports support this hypothesis regarding the relationship between inflammation and cognitive function. 17 Furthermore, high-sensitivity CRP has been shown to be a useful biomarker for cognitive impairment, [18][19][20] vascular dementia 21 and AD 22,23 in population-based studies. Inflammation is also known to be associated with risk factors for dementia, such as aging processes, tumor necrosis factor-α and tau proteins.…”

Section: Discussionmentioning

confidence: 99%

Serum albumin/globulin ratio is associated with cognitive function in community‐dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study

Maeda

Takeya

Oguro

et al. 2019

Geriatrics Gerontology Int

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Aim The objective of this study was to clarify the relationship between cognitive function and the serum albumin/globulin ratio (A/G ratio) in community‐dwelling Japanese older adults. Methods Randomly extracted residents in both urban and rural parts of Japan were enrolled in this study. A total of 1827 participants with a mean age of 70 or 80 years were recruited. A venue survey method was carried out with comprehensive studies, including interviews, blood collection, physical examination and cognitive function tests. Results Univariate analysis showed a significant positive correlation between the total Japanese version of the Montreal Cognitive Assessment score and the serum A/G ratio at the age of 70 and 80 years, in which better cognitive function was associated with a high serum A/G ratio. Multiple regression analysis with the total Japanese version of the Montreal Cognitive Assessment score as the dependent variable showed that the serum albumin level, serum globulin level, serum A/G ratio, C‐reactive protein, years of formal education and sex were related to the Japanese version of the Montreal Cognitive Assessment total score at the age of 70 years, and that the serum albumin level, serum globulin level, serum A/G ratio, C‐reactive protein, years of formal education and stroke were related at the age of 80 years. The serum A/G ratio showed a better correlation than the serum globulin levels at the age of 70 and 80 years (70 years: β = 0.131 vs –0.111, 80 years: β = 0.108 vs –0.071). Conclusions We found a correlation between cognitive function and the serum A/G ratio in community‐dwelling older people, suggesting that nutritional status and chronic inflammation might influence cognitive function. Geriatr Gerontol Int 2019; 19: 967–971.

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“…Because inflammation also has been shown to be associated with increased risk for adverse CVD events(32, 33) and impaired cognitive function, (34) we also sought to determine whether the relation between lifestyle factors and neurocognitive function is explained by C-reactive protein and CVD risk factors.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment

et al. 2017

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Objective To determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, without dementia (CIND). Methods One hundred sixty adults (Mean = 65.4±6.8 years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity determined by exercise testing, and dietary habits quantified by the Food Frequency Questionnaire and 4-Day Food Diary to assess adherence to the Mediterranean and DASH diets were obtained to assess direct effects with neurocognition. Potential indirect associations of high sensitivity C-Reactive Protein (hsCRP) and the Framingham Stroke Risk Profile (FSRP) also were examined. Results Greater aerobic capacity (β =0.24) and daily physical activity (β = 0.15) were associated with better Executive Functioning/Processing Speed and Verbal Memory (βs = 0.24; 0.16). Adherence to the DASH diet was associated with better Verbal Memory (β = 0.17). Greater hsCRP (βs = −0.14; −0.21) and FSRP (β= −0.18; −0.18) were associated with poorer Executive Functioning/Processing Speed and Verbal Memory. Greater stroke risk partially mediated the association of aerobic capacity with Executive Functioning/Processing Speed, and Verbal Memory, and greater inflammation partially mediated the association of physical activity and aerobic fitness, with Verbal Memory. Conclusions Higher levels of physical activity, aerobic fitness, and adherence to the DASH diet are associated with better neurocognitive performance in adults with CIND. These findings suggest that the adoption of healthy lifestyle habits could reduce the risk of neurocognitive decline in vulnerable older adults. Trial Registration NCT0157354

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Elevated C-Reactive Protein Is Associated with Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Cited by 51 publications

References 64 publications

Analysis of Risk Factors for Development of Cognitive Disorders in Maintenance Hemodialysis Patients – Pilot Study

Analysis of Risk Factors for Development of Cognitive Disorders in Maintenance Hemodialysis Patients – Pilot Study

Serum albumin/globulin ratio is associated with cognitive function in community‐dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study

Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment

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