C-Reactive Protein Level in Severe Stenosis of Cerebral Arteries

Abstract

Background: C-reactive protein (CRP) as a non-specific inflammatory biomarker has been demonstrated to actively contribute to all stages of atherogenesis. The aim of this study was to investigate the relation between CRP concentrations and the severity of stenosis of cerebral arteries. Methods: Lipid parameters and CRP levels were measured in the sera of 119 patients with stenosis of the extracranial cerebral arteries established by angiography and compared with the control group, with a normal appearance of the cerebral arteries on ultrasound examination. CRP concentrations were determined by a high-sensitivity assay. Results: CRP concentrations showed a statistically significant difference in the group of patients with cerebrovascular stenosis of more than 70% compared to the control group (median value 3.4 vs. 1.5 mg/l in the control group, p < 0.05). At logistic regression analysis, CRP was significantly associated with stenosis of more than 70%. Conclusion: In addition to traditional biochemical risk markers, an elevated CRP level measured on automated analysers using a high-sensitivity assay may be useful in the detection of patients with severe stenosis of the cerebral arteries.

Increased high-sensitivity C-reactive protein, erythrocyte sedimentation rate and lactic acid in stroke patients with internal carotid artery occlusion

“…To search for a less invasive and cheaper method to detect ICAO, inflammatory factors such as high-sensitivity C-reactive protein (hs-CRP) have been established in several prospective studies [ 10 – 12 ]. High-sensitivity CRP is a very sensitive non-specific biomarker contributing to all stages of atherosclerosis [ 10 , 13 – 15 ].…”

Association between Human Paraoxonase 1 Activity and Intima-Media Thickness in Subjects under 55 Years of Age with Carotid Artery Disease

“…There is growing evidence that the immune system plays a critical role at every stage of the atherosclerotic process, and recently atherosclerosis has been considered to be an essentially inflammatory phenomenon [1]. Oxidation of lipoproteins, as a result of chronic inflammation and immune response, plays a key role in the initiation and progression of atherosclerosis.…”

High-Sensitivity C-Reactive Protein: To Measure or not to Measure?~!2009-10-29~!2009-12-22~!2010-04-08~!

“…Similarly, in another study hsCRP concentration was significantly associated with cerebral arteries stenosis >70% [60]. Mullenix PS et al recently showed that hsCRP levels were independently associated with carotid stenosis (odds ratio [OR] 1.2, 95% CI 1.1-1.5, p=0.04), while LDL cholesterol levels were not (OR 1.0, 95% CI 0.98-1.01, p=0.8) [61].…”