C-reactive protein is a predictor of prognosis in renal cell carcinoma patients receiving tyrosine kinase inhibitors: A meta-analysis

Wang, Zhun; Peng, Shuanghe; Wang, Aixiang; Xie, Hui; Guo, Linpei; Jiang, Ning; Niu, Yuanjie

doi:10.1016/j.cca.2017.10.021

Cited by 12 publications

(14 citation statements)

References 38 publications

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“…TNM stage and Fuhrman nuclear grade are important prognostic factors for RCC, but these factors cannot accurately predict the prognosis. An increasing number of studies searched for additional factors, suggesting cachexia, platelet count, performance status, CRP, and others, may be potential prognostic factors for patients with RCC 34–37…”

Section: Discussionmentioning

confidence: 99%

“…Currently, more evidence revealed that local immune response and systemic inflammation are associated with tumor progression, metastasis, and survival of cancer patients 38,39. The inflammation response is characterized by white blood cells, platelets, lymphocytes, neutrophils, CRP, and albumin 37. And kinds of combinations of these factors, such as NLR, PLR, GPS, and mGPS, were reported to be predictive for prognosis of cancers, including RCC 10–18.…”

Section: Discussionmentioning

confidence: 99%

“…More studies suggested that CRP is associated with prognosis of various cancers 10–13. Wang performed a meta-analysis and found that elevated CRP is correlated with poor prognosis in patients with RCC 37. Some studies observed that RCC cells can produce IL-6, which is recognized as a promoter of tumor cells growth and functioned as an autocrine growth factor of RCC 41,42.…”

Section: Discussionmentioning

confidence: 99%

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<p>Modified Glasgow prognostic score as a prognostic factor for renal cell carcinomas: a systematic review and meta-analysis</p>

Hu¹,

Wang²,

Yang³

et al. 2019

CMAR

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Objective The modified Glasgow prognostic score (mGPS), a combination of C-reactive protein (CRP) and albumin levels, reflects systemic inflammation and nutritional status. This score has been shown to have prognosis value for various tumors. In the present study, we evaluated the prognostic value of mGPS for patients with renal cell carcinoma (RCC). Methods Literature search was conducted based on PubMed, Embase, and Cochrane Central Register of Controlled Trials up to December 2018. We pooled HRs and 95% CIs to evaluate the correlation between mGPS and survival in patients with RCC. Results Twelve studies comprising 2,391 patients were included in the present study for quantitative synthesis. Our studies demonstrated that higher mGPS was significantly correlated to poor overall survival (HR=4.31; 95%CI, 2.78–6.68; P <0.001), cancer-specific survival (HR=5.88; 95%CI, 3.93–8.78; P <0.001), recurrence-free survival (HR=3.15; 95%CI, 2.07–4.79; P <0.001), and progression-free survival (HR=1.91; 95%CI, 1.27–2.89; P =0.002). Subgroup analyses also confirmed the overall results. Conclusion mGPS could serve as a predictive tool for the survival of patients with RCC. In the different subgroups, the results are also consistent with previous results. In conclusion, pretreatment higher mGPS is associated with poorer survival in patients with RCC. Further external validations are necessary to strengthen this concept.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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<p>Modified Glasgow prognostic score as a prognostic factor for renal cell carcinomas: a systematic review and meta-analysis</p>

Hu¹,

Wang²,

Yang³

et al. 2019

CMAR

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“…Research has discovered that CRP produces inflammatory cytokines and chemokines, which lead to cancer progression [31]. Several studies have shown that high CRP level was linked to worse survival of RCC patients [32, 33]. Serum albumin is an objective indicator of nutritional status and clinical inflammation that is downregulated in inflammation [34].…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein to albumin ratio predicts the outcome in renal cell carcinoma: A meta-analysis

Zhou

Zhang

2019

PLoS ONE

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BackgroundGrowing evidence has revealed that pretreatment C-reactive protein to albumin ratio (CAR) are associated with prognosis for patients with renal cell carcinoma (RCC). However, inconsistent findings have been reported, which promote us to summarize the global predicting role of CAR for survival in RCC patients.MethodsTwo reviewers independently retrieved the literature on EMBASE, MEDLINE, and Cochrane Library databases for eligible studies evaluating the associations of CAR with survival. Data related to the overall survival (OS), disease-free survival (DFS), progress-free survival (PFS), and clinicopathological features were extracted and pooled using meta-analysis with fixed or random- effect models when applicable.ResultsEight studies including 2,829 patients were analyzed in the present study. High pretreatment CAR was associated with worse OS (pooled HR: 2.14, 95% CI = 1.64–2.79, p < 0.001) and DFS/PFS (pooled HR: 1.75, 95% CI: 1.31–2.35, P < 0.001). Moreover, high CAR was correlated with performance status (≥ 1), tumor location (left), Fuhrman grade (3–4), TNM stage (III-IV), T stage (T3-4), N stage (N1), M stage (M1), tumor necrosis (yes), venous thrombus (positive), metastasis at diagnosis (yes), NLR (> median), and PLR (> median).ConclusionHigh pretreatment CAR is effectively predictive of worse survival in patients with RCC and could be a prognostic biomarker for those patients.

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“…Increasing data suggest that hypertension, obesity, long-term sodium intake, high glycemic index diet, and cigarette smoking are the major risk factors for RCC 3–7 . Numerous studies have demonstrated that inflammatory molecules, such as C-reactive protein (CRP), promote RCC progression 8–10 . Other studies have indicated that inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), lead to a poor prognosis 11 .…”

Section: Introductionmentioning

confidence: 99%

The Vitamin D status is associated with serum C-reactive protein and adhesion molecules in patients with renal cell carcinoma

Song

Zhang

et al. 2019

Sci Rep

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Low vitamin D status is associated with an increased risk of renal cell carcinoma (RCC). This study investigated the association of vitamin D status with serum C-reactive protein (CRP) and adhesion molecules among RCC patients. Fifty newly diagnosed RCC patients and 100 age- and sex-matched controls were recruited. As expected, serum 25(OH)D level was lower in RCC patients than in controls. By contrast, serum levels of CRP, an inflammatory molecule, and ICAM, LAMA4 and EpCAM, three adhesion molecules, were higher in RCC patients than in controls. All RCC patients were divided into two groups: H-VitD (>20 ng/ml) or L-VitD (<20 ng/ml). Interestingly, the levels of serum CRP and all adhesion molecules were higher in RCC patients with L-VitD than those with H-VitD. Nuclear vitamin D receptor (VDR) was downregulated and nuclear factor kappa B (NF-κB) was activated in cancerous tissues. The in vitro experiments found that VitD3 suppressed NF-κB activation and adhesion molecules in RCC cells. Moreover, VitD3 suppressed NF-κB through reinforcing physical interaction between VDR and NF-κB p65 subunit in RCC cells. These results provide a mechanistic explanation for the association among low vitamin D status, local inflammation and increased expression of adhesion molecules among RCC patients.

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C-reactive protein is a predictor of prognosis in renal cell carcinoma patients receiving tyrosine kinase inhibitors: A meta-analysis

Cited by 12 publications

References 38 publications

<p>Modified Glasgow prognostic score as a prognostic factor for renal cell carcinomas: a systematic review and meta-analysis</p>

<p>Modified Glasgow prognostic score as a prognostic factor for renal cell carcinomas: a systematic review and meta-analysis</p>

C-reactive protein to albumin ratio predicts the outcome in renal cell carcinoma: A meta-analysis

The Vitamin D status is associated with serum C-reactive protein and adhesion molecules in patients with renal cell carcinoma

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