C-reactive protein in the Serial Assessment of Disease Activity in Rheumatoid Arthritis

Dixon, Jonathan S.; Bird, H. A.; Sitton, N. G.; Pickup, M. E.; Wright, V.

doi:10.3109/03009748409102666

Cited by 68 publications

(33 citation statements)

References 12 publications

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“…CRP concentration is known to be elevated in human RA and has been used as an index of disease activity and a prognostic factor [7,9,19]. In the present study, the CRP concentrations at the time of diagnosis were markedly elevated in all the IPA dogs, but these could not predict the long-term outcomes of the disease/medication status.…”

Section: Discussionmentioning

confidence: 51%

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Ohno

Yokoyama

Nakashima

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) in idiopathic polyarthritis (IPA), its concentration was measured in dogs with IPA. The CRP concentration was markedly increased in all the IPA dogs at the time of diagnosis and decreased significantly in response to the initial corticosteroid treatment; this indicated that CRP can be used as an index for therapeutic response in IPA cases. Furthermore, at 6 months after the diagnosis, a significant association was observed between the CRP concentration at follow-up (6-13 days after the treatment was started) and the frequency of medication ("no or seldom-medicated (NSM)" groups or "continuing medication (CM)" groups). These results suggest that the initial response of CRP to corticosteroid treatment may be a prognostic factor of canine IPA. KEY WORDS: canine, C-reactive protein, idiopathic polyarthritis.

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Section: Discussionmentioning

confidence: 51%

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Ohno

Yokoyama

Nakashima

et al. 2006

The Journal of Veterinary Medical Science

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“…Numerous studies have demonstrated the inability of NSAID therapy to influence serologic correlates of inflammation, including the ESR and CRP (2)(3)(4)(5)(6). Elevations in the levels of acute-phase reactants are characteristic findings in patients with active RA (1-3).…”

Section: Discussionmentioning

confidence: 99%

Correlation of serologic indicators of inflammation with effectiveness of nonsteroidal antiinflammatory drug therapy in rheumatoid arthritis

Cush

Lipsky

Postlethwaite

et al. 1990

Arthritis & Rheumatism

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Forty-seven patients with rheumatoid arthritis (mean duration 5.7 years) who were receiving neither disease-modifying drugs nor corticosteroids were enrolled in a 12-week, multicenter study of the relationship between clinical and serologic measures of disease activity in patients taking nonsteroidal antiinflammatory drugs. After a 2-week drug washout period, patients received flurbiprofen (200 mg/day) or sustained-release ibuprofen (2,400 mg/day) for a 10-week trial. Clinical response was assessed biweekly using standard clinical parameters, including 50-foot walk time, tender joint score, duration of morning stitfness, and global assessment of disease activity and pain (by both the patient and the physician). Patients were classified as responders if there was 230% improvement in at least 3 of the 4 clinical measures of disease activity. Thirty patients completed at least 8 weeks of therapy; there were 12 responders and 18 nonresponders. Of the laboratory From the Harold C.

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“…It has been found that changes in the concentration of CRP can reflect remission or exacerbation of RA [3]. Reductions in serum CRP have been shown to correlate with an improvement in clinical symptoms [4,5] and a decrease in radiologically assessed disease progression [6] measured via development of radiographic erosions [6,7].…”

Section: Introductionmentioning

confidence: 99%

The effects of age and gender on the pharmacokinetics of tenidap sodium in patients with rheumatoid arthritis and osteoarthritis.

Caldwell¹,

Kirby²,

Gardner³

et al. 1995

Brit J Clinical Pharma

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1. This open‐label study was conducted to evaluate the effects of age and gender on the pharmacokinetics of tenidap sodium in patients with either rheumatoid arthritis (RA) or osteoarthritis (OA). 2. A total of 145 male and female patients, 80 with RA (aged 22‐91 years) and 65 with OA (aged 45‐83 years) each received a single dose of 120 mg tenidap sodium. Pharmacokinetic parameters were estimated from individual tenidap plasma concentration‐time curves determined up to 120 h post‐ dose. Tenidap plasma protein binding was determined in the youngest and oldest age groups for both RA and OA patients. 3. In RA patients, age and gender did not significantly affect the disposition of tenidap or the percentage of unbound tenidap in plasma. Only for tmax were statistically significant effects in the analysis of covariance observed and these were attributed to very high tmax values in two female patients. Likewise, in patients with OA, age and gender did not significantly affect the pharmacokinetics of tenidap, although patients with larger body weights had lower Cmax values. 4. Pharmacokinetic parameters were not significantly different between RA and OA patients, except for t1/2, where two outlier RA patients had low values that caused the mean value to be significantly lower in RA (24 h) than in OA (26 h) patients. Pharmacokinetic parameters for pooled values from RA and OA patients were as follows: t1/2 = 25 h, AUC = 538.4 micrograms ml‐ 1 h, Cmax = 21.9 micrograms ml‐1, tmax = 3.2 h.(ABSTRACT TRUNCATED AT 250 WORDS)

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C-reactive protein in the Serial Assessment of Disease Activity in Rheumatoid Arthritis

Cited by 68 publications

References 12 publications

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

C-Reactive Protein Concentration in Canine Idiopathic Polyarthritis

Correlation of serologic indicators of inflammation with effectiveness of nonsteroidal antiinflammatory drug therapy in rheumatoid arthritis

The effects of age and gender on the pharmacokinetics of tenidap sodium in patients with rheumatoid arthritis and osteoarthritis.

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