C-reactive protein in pregnancy and contraception

Connell, Elizabeth B.; Connell, John T.

doi:10.1016/0002-9378(71)90243-2

Cited by 26 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contradictory reports concerning circulating CRP concentrations in healthy pregnant women have been published. In some studies, rising concentrations of CRP are reported to occur with increasing length of gestation, while in others no such change has been observed (9,12,16,17). In our study, 30% of preoperative CRP values in pregnant women operated without labor and rupture of the membranes were higher than 10 mg/l, the usual upper value considered normal for nonpregnant persons (18).…”

Section: Discussionmentioning

confidence: 99%

C‐reactive protein in uncomplicated parturients delivered by Cesarean section

Keski‐Nisula

Kirkinen

Ollikainen

et al. 1997

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

C‐reactive protein in uncomplicated parturients delivered by Cesarean section

Keski‐Nisula

Kirkinen

Ollikainen

et al. 1997

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…12 Recent studies have shown that hormone replacement therapy in postmenopausal women is associated with elevated CRP 13,14 with a potential adverse cardiovascular risk. Early reports suggested that there may be a link between oral contraceptives and CRP 15,16 and an open label study has suggested increases in CRP in young women treated with third-generation combined oral contraceptives. 17 There have been long-standing concerns about the possible cardiovascular risks associated with combined oral contraceptive use 18 but limited understanding of possible mechanisms of arterial disease in a predominantly younger age group of women.…”

Section: Introductionmentioning

confidence: 99%

Association between C-reactive protein, metabolic cardiovascular risk factors, obesity and oral contraceptive use in young adults

Williams

Milne

et al. 2004

Int J Obes

View full text Add to dashboard Cite

OBJECTIVE: This study sought to determine the relationship between levels of the inflammatory marker, C-reactive protein (CRP), cardiovascular risk factors and oral contraceptive use in young adults. DESIGN: Cross-sectional study of a community cohort. SUBJECTS: A total of 822 men and women aged 26 y. MEASUREMENTS: CRP, body mass index (BMI), blood pressure, lipid and lipoprotein levels, smoking status, socioeconomic status, health status, and hormonal contraceptive use in women. RESULTS: Multiple regression analysis showed that obesity was independently related to CRP with an increase in ratio CRP of 1.03 (95% CI 1.01, 1.05) for men and 1.07 (1.05, 1.09) for women associated with a 1 kg/m 2 increase in BMI. In women, combined oral contraceptive use was associated with a ratio change in CRP of 1.52 (1.27, 1.82) compared with nonusers. Other independent determinants of CRP in men and women were apolipoprotein B level, systolic blood pressure and apolipoprotein A1 in men. Univariate analysis showed that the relationship between CRP and BMI, systolic blood pressure and apolipoprotein B was significantly stronger in women than men. CONCLUSION: These findings suggest that obesity is associated with inflammation independent of other cardiovascular risk factors that may contribute to an increased risk for cardiovascular disease in men and women. Elevated CRP related to combined oral contraceptive use may influence the rate of cardiovascular events in young women.

show abstract

“…However, these studies did not examine the CRP trend during pregnancy (Miller, ; Picklesimer et al, ; Sacks et al, ; von Versen‐Hoeynck et al, ; Watts et al, ). Early studies using qualitative methods showed either no significant increase from the first trimester through delivery or a decline (Connell and Connell, ; Yeh, ). Connell and Connell () studied 611 pregnant women in the United States and found that the percentages of positive (detectable) tests of CRP, taken from the first trimester through delivery, were not significantly different from one another.…”

mentioning

confidence: 99%

“…Early studies using qualitative methods showed either no significant increase from the first trimester through delivery or a decline (Connell and Connell, ; Yeh, ). Connell and Connell () studied 611 pregnant women in the United States and found that the percentages of positive (detectable) tests of CRP, taken from the first trimester through delivery, were not significantly different from one another. However, the method used for that study was only qualitative and could not determine CRP value.…”

mentioning

confidence: 99%