C-reactive protein (CRP) in cerebro-vascular events

Canova, Corina; Courtin, Christophe M.; Reinhart, Walter H.

doi:10.1016/s0021-9150(99)00162-8

Cited by 52 publications

(51 citation statements)

References 29 publications

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“…C reactive protein values are higher in AIS patients at admission, and are correlated with stroke severity 18 . C reactive protein is a marker of the local severity of "brain attack" 19,20 . This study showed that the rate of elevated CRP was higher in the AIS than in the control group; higher CRP was more prevalent in the severe stroke in terms of NIHSS score, and similarly, a higher incidence of severe stroke was more prevalent in the elevated CRP group.…”

Section: Discussionmentioning

confidence: 99%

Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Luo

Wang²,

Li³

et al. 2012

Can. J. Neurol. Sci.

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Elevated serum C reactive protein (CRP) concentrations have been found in acute ischemic stroke (AIS) patients [1][2][3][4][5][6][7][8][9][10] , which reflects a systemic inflammatory response following stroke 1 . It is possible that the increased CRP has a close relationship with the extent of cerebral tissue injury 2 . Previously studies paid more attention to its prognostic role of outcome, however, study on the correlation between elevated CRP levels and stroke severity, especially with the stroke subtype is limited.The aim of this retrospective study was to investigate elevated CRP in relation to stroke severity, and analyze its different distribution in stroke subtypes. Here, three subtypes of ischemic stroke were studied, taking into account etiology and clinical and image classification. METHODS Study designData for this study were obtained at Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ABSTRACT: Objective: The aim of this retrospective study was to investigate if elevated C reactive protein (CRP) was related to the stroke severity, and to analyze its different distribution in stroke subtypes. Methods: 316 patients with acute ischemic stroke (AIS) were enrolled and had CRP determinations; they were dichotomized as<7 or≥7mg/L according to the previous report. 128 patients with transient ischemic attack who also had CRP measurements were selected as controls. A possible level-risk relationship between elevated CRP and NIHSS, which considered relatively severe illness as a value≥8, was studied within the AIS group. Results: CRP was elevated in 21% of the AIS compared to 4% in the control group (p = 0.000). Within the AIS group, patients with CRP levels ≥7mg/L had a significantly increased risk of severe stroke (OR 3.33, 95% CI 1.84-6.00, p =0.00). In subtype stroke, the highest rate of elevated CRP and NIHSS were in those with cardioembolic stroke (CE) using TOAST classification, total anterior circulation infarction (TACI) of OCSP classification and large volume infarction (LVI) of Adams classification; the odds ratio(OR) between elevated CRP and NIHSS was 6.14 (95% CI 1.43-26.44) in CE, 1.714 (95% CI 1.30-2.26) in TACI, 2.32 (95% CI 1.08-4.99) in LVI, and the p value were all below 0.05. Conclusion: Elevated CRP level can reflect the severity of AIS, which was association with stroke subtype.

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Section: Discussionmentioning

confidence: 99%

Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Luo

Wang²,

Li³

et al. 2012

Can. J. Neurol. Sci.

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“…Serial serum PCT levels did not correlate with stroke mortality or neurologic outcome at discharge. Studies have correlated laboratory parameters with prognosis in acute stroke, sometimes with conflicting results [5][6][7]. Prognostic utility of laboratory parameters in acute stroke is limited by the need to perform serial measurements, together with the interrelation of at least some of the inflammatory markers.…”

Section: To the Editormentioning

confidence: 99%

Serial serum procalcitonin changes in the prognosis of acute stroke

Miyakis

Georgakopoulos

Kiagia

et al. 2004

Clinica Chimica Acta

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“…Creactive protein (CRP), haptoglobin (Hp), ceruloplasmin (Cp), serum amyloid A (SAA), α-1 acid glycoprotein, and fibrinogen are positive APPs, and their blood concentrations are elevated mainly due to increased production in the liver [3]. On the other hand, albumin and transferin are known as negative APPs [5].…”

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confidence: 99%

C-Reactive Protein Concentration in Dogs with Various Diseases

et al. 2008

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ABSTRACT. To investigate the clinical utility of C-reactive protein (CRP) determination in dogs, its plasma concentration was measured by a laser nephelometric method in 928 dogs with various diseases, and was compared with other inflammatory parameters. CRP concentration was elevated in various inflammatory diseases, this was most frequently observed in cases with neoplastic and immune-mediated diseases. All cases of pyometra, panniculitis, acute pancreatitis, polyarthritis, and hemangiosarcoma showed significantly elevated CRP concentrations. On the other hand, the CRP concentration was elevated only in few cases of neurological diseases such as epilepsy, meningoencephalitis, and hydrocephalus and endocrine diseases such as hypothyroidism, hyperadrenocorticism, and diabetes mellitus. Only a weak correlation was observed between the CRP concentration and white blood cell (WBC) counts (r=0.44) but no correlation with band neutrophil counts. There was no correlation between the CRP and albumin concentrations, but a weak negative correlation (r=-0.40) when excluding chronic intestinal diseases and nephrotic syndrome, which can cause protein loss. Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test. KEY WORDS: albumin, C-reactive protein (CRP), canine, neutrophil, WBC.

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C-reactive protein (CRP) in cerebro-vascular events

Cited by 52 publications

References 29 publications

Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Serum CRP Concentrations and Severity of Ischemic Stroke Subtypes

Serial serum procalcitonin changes in the prognosis of acute stroke

C-Reactive Protein Concentration in Dogs with Various Diseases

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