C-reactive protein as an indicator of resolution of sepsis in the intensive care unit

Abstract

Daily measurement of CRP is useful for monitoring the course of microbiologically-proven sepsis in ICU patients, and may be used to indicate successful treatment.

Interleukin-6 and C-reactive protein as early markers of sepsis in patients with diabetic ketoacidosis or hyperosmosis

“…We also observed that CRP together with IL-6 concentrations decreased significantly during remission, while b-2 microglobulin remained increased. Both CRP and various cytokines, including IL-6, have previously been reported to predict the development of post-operative sepsis and multiple organ failure and as an indicator of septic complications and monitoring of sepsis [9,10].…”

Failure to reduce C-reactive protein levels more than 25% in the last 24 hours before intensive care unit discharge predicts higher in-hospital mortality: A cohort study

“….134 Respiratory failure 117 (29) 98 (29) 19 (25) .942 Shock b 66 (16) 46 (14) 20 (27) .006 Sepsis/severe sepsis 53 (13) 40 (12) 13 (17) .212 CNS disorders 51 (13) 43 (13) 525.e11 Failure to reduce CRP predicts higher in hospital mortality predefined time window to avoid bias due to CRP half-life and sample-collect routine. Regarding the CRP-48 h, only results collected up to 50 hours (2 hours of difference) were considered valid.…”

“…Evaluation of CRP trend pattern in the first days of ICU admission has been reported as useful in discriminating outcomes in community-acquired pneumonia [15] and septic patients [16] and useful to help in the clinical decision-making process regarding ICU-acquired infections [17][18][19].…”

C-reactive protein: an early predictor of sepsis in patients with thermal burns

“…18 Yentis SM et al and Ellis S et al showed that measurement of CRP can be used to monitor the antibiotic therapy and that successful antibiotic therapy lowered CRP levels. 19,20 As a summary, this study has thrown up positive results regarding the utility of CRP in burn patients. The CRP values correctly predict sepsis in majority of the patients.…”