Interleukin-6 and C-reactive protein as early markers of sepsis in patients with diabetic ketoacidosis or hyperosmosis

Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis

“…Nonsurvivors of diabetic ketoacidosis have higher CRP levels than survivors [26]. The predictive power of CRP in our study is even less than previously reported by Oberhoffer et al (AUC 0.620) [8].…”

“…Distribution [26] and high peak IL-6 level (>1000 pg/ml) [17,27,28,29,30] have been reported to be correlated with poor outcome in septic patient. In contrast, Gogos et al [31] found that IL-10 and not IL-6 is the main predictor of fatal outcome.…”

Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia

“…15 Interleukin-6 is a pleiotropic cytokine with a broad range of effects relating to inflammation, host defence and tissue injury, 16 while it has been shown to be associated with the severity of critical illness 17 and the presence of sepsis in patients with diabetic ketoacidosis. 18 Interestingly, increased IL-6 serum concentrations are related to insulin resistance 19 and IL-6 contributes to hyperglycemia through glucose release from hepatic glycogen stores. 20 On the other hand, hyperglycemia itself increases the serum concentrations of IL-6, possibly through augmented production in monocytes.…”

The management of the hyperosmolar hyperglycaemic state in adults with diabetes: a summary of a report from the Joint British Diabetes Societies for Inpatient Care

“…An infective source should be sought on clinical history and examination and C-reactive protein may be helpful. 39 Give antibiotics when there is clinical, imaging or laboratory evidence of infection.…”