C-Reactive Protein and other Hematological parameters for diagnosis of Neonatal Sepsis

Patel, Umesh; Patel, Vishnu Kumar; Patel, Narmada Prasad; Verma, Jyotsna; Ratre, Bhupendra Kumar; Verma, Savita

doi:10.17511/ijmrr.2014.i04.09

Cited by 10 publications

(9 citation statements)

References 12 publications

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“…PPV (76.92%) of present study was in concordance with Rodwell et al [14] Present study showed high sensitivity (84.21%) for CRP levels in culture proven babies. This findings are in concordance with Ghafoor et al [26] and Supreetha et al [13] Results of Amrita Duhan et al [20] , Gautam C et al [27] and Patel U et al [32] showed high specificity compared to sensitivity. For combined CRP and I/T Ratio sensitivity, specificity, PPV and NPV were 7.89%, 87.50%, 66.66% and 23.7% respectively in present study.…”

Section: Discussionsupporting

confidence: 92%

“…For combined CRP and I/T Ratio sensitivity, specificity, PPV and NPV were 7.89%, 87.50%, 66.66% and 23.7% respectively in present study. Patel U et al [32] showed sensitivity, specificity, PPV and NPV of 77.6%, 100%, 100% and 50% respectively, while Maysaa Sayed et al reported sensitivity, specificity, PPV and NPV of 65%, 100%, 100% and 74% respectively. [33] However, this did not yield much significance from their individual utility, except for few combination, like combination of ANC and I/T Ratio achieved more specificity than ANC alone.…”

Section: Discussionmentioning

confidence: 99%

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A study of hematological parameters in neontal sepsis

Chaudhari¹,

Narola²

2021

Int. J. Clin. Diagn. Pathol.

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Introduction: Neonatal septicemia is major cause of morbidity and mortality in newborns, which requires early diagnosis and prompt treatment to reduce case fatality rate with help of various hematological parameters, till results of blood culture become available. Aims: The present study was undertaken to analyse the efficacy of various hematological parameters in comparison with blood culture in neonates presented with septicemia. Methods and Material: Blood samples were received in central diagnostic laboratory, Shree Krishna Hospital, Karamsad and processed in respective sectional laboratory. Efficacy of all the parameters were assessed by measuring sensitivity, specificity, PPV and NPV. Results: Out of 100 cases, culture positivity was seen in 76% of cases with male preponderance (59%). Toxic granulation (TG) was the most sensitive test (86.84%). The most specific test was TLC (91.66%). Conclusions:The hematologic parameters are simple and cost effective tests, reports of which are obtained within few hours which helps in early initiation of treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A study of hematological parameters in neontal sepsis

Chaudhari¹,

Narola²

2021

Int. J. Clin. Diagn. Pathol.

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“…Neonatal sepsis is a life-threatening disorder that is responsible for about 15% of all neonatal deaths in developing countries [ 22 , 23 ]. It is characterized by signs and symptoms of microbial infection, usually bacteria, in the first month of life [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Role of complete blood cell count parameters in the diagnosis of neonatal sepsis

et al. 2022

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Background Neonatal sepsis is one of the leading causes of neonatal morbidity and mortality in developing countries like Ethiopia. The investigation of neonatal sepsis needs the application of inclusive diagnostic tools. Therefore, this study aimed to assess the role of CBC parameters in diagnosing neonatal sepsis. Methods A comparative cross-sectional study was conducted from September 2020 to November 2021 at the University of Gondar Comprehensive Specialized Hospital. A total of 250 neonates were included using a convenient sampling technique. A structured questionnaire and a data collection sheet were used to obtain the socio-demographic and clinical characteristics of the study participants. A venous blood sample was collected for CBC and blood culture tests. Epi-Info Version 7 and SPSS Version 25 were used for data entry and analysis, respectively. The data distribution was checked by the Shapiro-Wilk test. Then, an independent t-test was conducted to compare CBC parameters, and the significant parameters were recruited for the ROC curves analysis. The Younden index test was used to determine the cutoff point for the sensitivity and specificity. A p-value of <0.05 was considered statistically significant. Results Out of 250 study participants, 144 (57.6%) were males, with a median age of 6 days (IQR = 4 days). Early-onset and late-onset sepsis were developed in about 29.6% (37/250) and 70.4% (88/250) of the neonates, respectively. The TLC and ANC parameters were significantly lower in cases than in control groups. The TLC, Hgb, lymphocyte count, and ANC parameters have a sensitivity of 64.8, 68, 33.6, and 49.6%, respectively. Their specificity in the diagnosis of neonatal sepsis was 64.8, 53.6, 83.2, and 90.4%, respectively. Conclusion Total leucocyte count, ANC, and platelet count all showed significant associations with neonatal sepsis. Besides, the TLC, ANC, and platelet counts had good sensitivity and specificity in diagnosing neonatal sepsis. Therefore, these parameters can be used as a diagnostic tool for neonatal sepsis in resource-limited areas.

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“…Risk of missing a sepsis prone patient with a certain infection is higher than the risk of antibiotics over treatment, so a low specificity and low positive predictive value are acceptable [ 21 ]. Although the gold standard test for diagnosing sepsis is blood culture, but the procedure is time consuming and expensive as it takes 48–72 h [ 22 ]. Also the technique requires a well-equipped laboratory setup which is mostly non available in most of the community hospitals [ 23 ].…”

Section: Discussionmentioning

confidence: 99%