Diagnostic utility of combined immature and total neutrophil counts along with C-reactive protein in early detection of neonatal sepsis: A cross-sectional study

Bhutani, Namita; Jethani, Sumit; Yadav, Abhishek

doi:10.1016/j.amsu.2022.103589

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Although repeated blood drawing cannot be recommended in neonates, Murphy and Weiner demonstrated that two normal I/T ratios correlated with a sterile blood culture and had a maximum negative predictive value of 100%, allowing at least to exclude sepsis even if they could not confirm the diagnosis [ 39 ]. Combining these biomarkers with each other or with other biomarkers can improve results, but always with great interpretative limits [ 40 ]. On the other hand, interpretation for neutrophils and band forms from stained blood smears is, per se, a limit, as it can significantly vary from laboratory to laboratory [ 41 ].…”

Section: Biomarkers Presently Used In Clinical Practicementioning

confidence: 99%

Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going

Boscarino,

Migliorino,

Carbone

et al. 2023

Antibiotics

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Neonatal sepsis is a bacterial bloodstream infection leading to severe clinical manifestations frequently associated with death or irreversible long-term deficits. Antibiotics are the drug of choice to treat sepsis, regardless of age. In neonates, the lack of reliable criteria for a definite diagnosis and the supposition that an early antibiotic administration could reduce sepsis development in children at risk have led to a relevant antibiotic overuse for both prevention and therapy. The availability of biomarkers of neonatal sepsis that could alert the physician to an early diagnosis of neonatal sepsis could improve the short and long-term outcomes of true sepsis cases and reduce the indiscriminate and deleterious use of preventive antibiotics. The main aim of this narrative review is to summarize the main results in this regard and to detail the accuracy of currently used biomarkers for the early diagnosis of neonatal sepsis. Literature analysis showed that, despite intense research, the diagnosis of neonatal sepsis and the conduct of antibiotic therapy cannot be at present decided on the basis of a single biomarker. Given the importance of the problem and the need to reduce the abuse of antibiotics, further studies are urgently required. However, instead of looking for new biomarkers, it seems easier and more productive to test combinations of two or more of the presently available biomarkers. Moreover, studies based on omics technologies should be strongly boosted. However, while waiting for new information, the use of the clinical scores prepared by some scientific institutions could be suggested. Based on maternal risk factors and infant clinical indicators, sepsis risk can be calculated, and a significant reduction in antibiotic consumption can be obtained.

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Section: Biomarkers Presently Used In Clinical Practicementioning

confidence: 99%

Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going

Boscarino,

Migliorino,

Carbone

et al. 2023

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Jethani et al utilised immature to total neutrophil ratio, absolute neutrophil count, and serum CRP. They reported that these parameters were helpful in the early diagnosis of neonatal sepsis[20].Platelets play an essential role in thrombosis and immune responses. The interaction of platelets with white blood cells via adhesion molecules and immune modulators plays a vital role in inflammation.…”

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confidence: 99%