C‐reactive protein and incident hypertension in a worksite population of Japanese men

Kansui, Yasuo; Matsumura, Kiyoshi; Morinaga, Yuki; Inoue, Minako; Kiyohara, Kanako; Ohta, Yuko; Gotō, Kenichi; Ohtsubo, Toshio; Ooboshi, Hiroaki; Kitazono, Takanari

doi:10.1111/jch.13510

Cited by 10 publications

(8 citation statements)

References 46 publications

(78 reference statements)

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“…In a study of the effect on the risk of hypertension in the US retired population, which included 2924 participants, logistic regression showed that CRP could be used as a predictor of hypertension in women [ 15 ]. In another study of CRP and hypertension in Japanese men [ 16 ], 2991 male workers without hypertension were evaluated, and the risk ratio (HR) for the occurrence of hypertensive events was estimated based on the quartiles of CRP, and 579 (19.4%) subjects developed hypertension during the 5-year follow-up period, and the incidence of hypertension increased with increasing levels of CRP, and the HR increased significantly with increasing CRP levels. This may imply that the development of hypertension involves a pathological process in which inflammation is involved and that the inflammatory response may be the direct cause of hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the development of arthritis is undoubtedly an important cause of reduced quality of life in elderly or even elderly patients, and arthritis as an inflammatory condition is closely associated with CRP. For example, patients with rheumatoid arthritis usually have persistently elevated CRP levels, with baseline CRP levels often exceeding 20 mg/L in randomized clinical trials of drugs for rheumatoid arthritis [ 16 ], however, retrospective and observational studies have found that many patients with rheumatoid arthritis have normal CRP levels despite exhibiting disease activity, suggesting that CRP levels only reflect signs of disease activity [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

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The relationship between serum C-reactive protein and senile hypertension

Fan

2022

BMC Cardiovasc Disord

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Background Hypertension has become an important health risk factor in the twenty-first century, especially for the elderly. Studies have confirmed that inflammation is involved in the development of hypertension and that the inflammatory marker C-reactive protein(CRP) is significantly associated with hypertension. Therefore, in this study, we aimed to explore the CRP correlation with hypertension in the elderly. Methods Serum CRP levels were measured in 196 hospitalized patients, and the CRP level was used as a criterion to divide them into the group with elevated CRP (> 10 mmol/L, n = 120) and the group with normal CRP (0 < CRP ≤ 10 mmol/L, n = 76). and the patient's baseline characteristics were collected and compared between the groups, and the correlation between CRP and other factors and hypertension in the elderly was analyzed by multi-factor logistic regression. Results The prevalence of hypertension, coronary artery disease and joint reactive inflammation was significantly higher in the group with elevated CRP. There was also a significant association between the use of alcohol, low density lipoprotein cholesterol (LDL-C) and steroids and elevated CRP; logistic regression showed that elevated CRP (OR = 2.13, 95% CI: 1.14–3.99, p = 0.019), body mass index (BMI) (OR = 1.10, 95% CI:1.01–1.90, p = 0.030), diabetes (OR = 2.68, 95% CI:1.24–5.79, p = 0.012) were positively associated with hypertension, while statins use was negatively associated with hypertension (OR = 0.49, 95% CI: 0.25–0.94, p = 0.013). Conclusions Elevated CRP, BMI, and diabetes are positively associated with hypertension in the elderly, and early screening for CRP and initiation of treatment may help prevent further inflammatory responses in hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The relationship between serum C-reactive protein and senile hypertension

Fan

2022

BMC Cardiovasc Disord

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“…Increased calprotectin secretion has been shown to occur as a result of the interaction between endothelial cells and cells involved in the inflammatory process. Several studies investigating inflammation and pathogenetic processes in hypertension have reported higher serum CRP, uric acid, and calcium levels [23][24][25][26][27][28]. Among these parameters, serum uric acid and calcium levels were found to exert a negative effect on serum calprotectin levels.…”

Section: Discussionmentioning

confidence: 98%

Serum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients

Bayrakci

Özkan

Kara

et al. 2022

International Journal of Hypertension

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Background. Hypertension is one of the leading causes of cardiovascular mortality. Although the pathogenetic process involved is not yet fully understood, the disease involves endothelial damage and inflammation. Calprotectin is an inflammatory marker that rises in parallel with disease activity in conditions such as systemic inflammatory diseases, infection, and atherosclerosis. The purpose of this study was to evaluate inflammation through serum calprotectin levels in newly diagnosed primary hypertension patients. Methods. Forty-nine newly diagnosed hypertensive patients and 38 healthy adults were included in the study. Patients’ office blood pressure values, biochemical findings, and demographic characteristics were recorded. Serum calprotectin levels were measured using ELISA. Parameters affecting serum calprotectin levels and determinants of hypertension were evaluated. Results. Serum calprotectin levels were 242.8 (72.4–524) ng/mL in the control group and 112.6 (67.4–389.8) ng/mL in the hypertensive patient group, the difference being statistically significant ( p = 0.001 ). There was no correlation between serum calprotectin levels and other parameters (blood pressure values, age, gender, serum creatinine, uric acid, and calcium levels) in the hypertensive group. A lower serum calprotectin level was found to be independently related to hypertension (β = −0.009, p = 0.005 ). Serum calprotectin at a cutoff level of 128.6 ng/mL differentiated hypertensives from healthy controls with a sensitivity of 69.4% and specificity of 68.4% (AUC = 0.767). Conclusions. The results of this study were the opposite of our hypothesis that a higher calprotectin level may reflect subclinical endothelial damage in newly diagnosed hypertensive patients. Further comparative studies involving patients at different stages of hypertension may contribute to clarifying the relationship between calprotectin and hypertension. We conclude that molecular studies seem essential for understanding the place of calprotectin in hypertension-associated inflammation, a complex process.

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“…Obesitas telah diketahui berhubungan dengan peningkatan risiko penyakit kardiovaskular, seperti hipertensi, hiperlipidemia, diabetes dan penyakit jantung koroner. Ding et al 14 CRP secara langsung berikatan dengan oxidized low-density lipoprotein cholesterol (LDL-C) yang aterogenik dan terdapat di dalam plak yang mengandung lipid 16,17 . Berdasarkan hal tersebut, pemeriksaan hs-CRP dapat digunakan sebagai biomarker untuk memprediksi risiko penyakit jantung pada seseorang yang sehat.…”

Section: Pembahasanunclassified

Evaluasi HbA1c, hs-CRP, dan indeks massa tubuh pada populasi sehat: Sebuah studi komunitas

Wahyuningsih

Anshori

Herningtyas

et al. 2019

J Community Empowerment for Health

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Insulin resistance as a cause of type 2 diabetes mellitus is associated with subclinical inflammatory processes. Insulin resistance with obesity, hypertension, and dyslipidemia contribute to metabolic syndrome that increased risk of cardiovascular disease. High sensitivity C-reactive protein (hs-CRP) is an inflammatory marker that is thought to be associated with both type 2 diabetes mellitus and cardiovascular disease. This study evaluated hs-CRP, HbA1c, and body mass index in a healthy community. This cross-sectional study is an observational analytic study evaluating the association between hs-CRP, HbA1c, and body mass index. The research subjects were all healthy on a community gathering in community service programs, and if there were any signs or symptoms of infection or inflammation, they would be excluded. Measurements of hs-CRP and HbA1c were carried out using the HPLC and ELISA methods, respectively. The measurement results were analyzed to evaluate the characteristics of the subject and assess the relationship between the parameters studied with different mean and correlation tests. In 25 subjects involved, it was found that 96% had an HbA1c value of <6.5% with a normal body mass index of 15 subjects (60%), and the rest were in the category of overweight. The median hs-CRP level was 2.99 mg / L (0.81-13.74 mg / L), with a low heart risk category of only 4% of all study subjects. There was no correlation between hs-CRP with HbA1c (r = 0.35; p = 0.868) and body mass index (r = 0.37; p = 0.069). Only one subject was included in the diabetes diagnostic criteria, but 96% of the study population had hs-CRP, which was included in the medium-risk and high-risk category for heart disease. There was no association between hs-CRP and HbA1c and body mass index in healthy populations in this community.

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C‐reactive protein and incident hypertension in a worksite population of Japanese men

Cited by 10 publications

References 46 publications

The relationship between serum C-reactive protein and senile hypertension

The relationship between serum C-reactive protein and senile hypertension

Serum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients

Evaluasi HbA1c, hs-CRP, dan indeks massa tubuh pada populasi sehat: Sebuah studi komunitas

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