The relationship between serum C-reactive protein and senile hypertension

Abstract

Background Hypertension has become an important health risk factor in the twenty-first century, especially for the elderly. Studies have confirmed that inflammation is involved in the development of hypertension and that the inflammatory marker C-reactive protein(CRP) is significantly associated with hypertension. Therefore, in this study, we aimed to explore the CRP correlation with hypertension in the elderly. Methods Serum CRP levels were measured in 196 hospitalized patients, and the CRP level was used as a criterion to divide them into the group with elevated CRP (> 10 mmol/L, n = 120) and the group with normal CRP (0 < CRP ≤ 10 mmol/L, n = 76). and the patient's baseline characteristics were collected and compared between the groups, and the correlation between CRP and other factors and hypertension in the elderly was analyzed by multi-factor logistic regression. Results The prevalence of hypertension, coronary artery disease and joint reactive inflammation was significantly higher in the group with elevated CRP. There was also a significant association between the use of alcohol, low density lipoprotein cholesterol (LDL-C) and steroids and elevated CRP; logistic regression showed that elevated CRP (OR = 2.13, 95% CI: 1.14–3.99, p = 0.019), body mass index (BMI) (OR = 1.10, 95% CI:1.01–1.90, p = 0.030), diabetes (OR = 2.68, 95% CI:1.24–5.79, p = 0.012) were positively associated with hypertension, while statins use was negatively associated with hypertension (OR = 0.49, 95% CI: 0.25–0.94, p = 0.013). Conclusions Elevated CRP, BMI, and diabetes are positively associated with hypertension in the elderly, and early screening for CRP and initiation of treatment may help prevent further inflammatory responses in hypertension.

Health Outcome Comparison Based on Dietary Inflammatory Levels among Sample of Korean Elderly

“…The BMI of the participants was 23.3 kg/m 2 , similar to that reported by Seo et al [24], who examined the impact of BMI on the physical fitness of the elderly in South Korea, and by He et al [25], who investigated the relationship between serum CRP levels and senile hypertension. Impairments to ADL, which reflect the physical health status of the elderly, tend to increase with age, indicating a decline in physical function with aging [26].…”

Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review

“…Several studies have shown a positive correlation between CRP and hypertension (Table 2). For instance, a study of 196 hypertensive patients over the age of 65 found that the increase in CRP was positively correlated with hypertension in the elderly, though not with the severity of hypertension [17]. Another randomized clinical trial [18] of 243 patients over 24 months found that high levels of C-reactive protein, measured using a high-sensitivity CRP (hs-CRP) assay, were related to HMOD, and hypertensive patients with combined organ damage had higher hs-CRP than hypertensive patients without organ damage.…”