C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso, Andreia Medeiros Rodrigues; Cardoso, Renata Oliveira; Carvalho, Danielle Franklin de; Collet, Neusa; Medeiros, Carla Campos Muniz

doi:10.1590/1415-52732014000300002

Cited by 3 publications

(3 citation statements)

References 22 publications

(25 reference statements)

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“…The prevalence of these risk factors may in fact be more common than previously reported (Weiss et al 2004). Our study confirms reports of D r a f t adolescents residing in high-income countries (Freedman et al 1999;Herder et al 2007;Caserta et al 2010;Maximova et al 2013), in Brazil (Brasil et al 2007;Silva et al 2010;Cardoso et al 2014;Azevedo et al 2015), and in other upper middle-income countries (Kelishadi et al 2007;Agirbasli et al 2015), which have shown increases in risk markers at an early age. In addition, unlike previous studies, the present study estimated the likelihood of Brazilian adolescents with excess body weight having altered values of cardiometabolic risk markers considering 14 different markers.…”

Section: Discussionsupporting

confidence: 88%

Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents

Mastroeni

Gonçalves

et al. 2016

Appl. Physiol. Nutr. Metab.

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Excess body weight leads to a variety of metabolic changes and increases the risk for cardiovascular diseases (CVD) in adulthood. The objective of this study was to investigate the presence of risk markers for CVD among Brazilian adolescents of normal weight and with excess body weight. The markers included blood pressure, C-reactive protein, homocysteine, tumor necrosis factor alpha, fibrinogen, fasting insulin and glucose, homeostasis model assessment of insulin resistance (HOMA-IR), leptin, total cholesterol, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and triglycerides. We calculated odds ratios (OR) using logistic regression and adjusted for potential confounders such as age, sex, physical activity, and socioeconomic background. Compared with normal weight subjects, overweight/obese adolescents were more likely to have higher systolic blood pressure (OR = 3.49, p < 0.001), fasting insulin (OR = 8.03, p < 0.001), HOMA-IR (OR = 8.03, p < 0.001), leptin (OR = 5.55, p < 0.001), and LDL-c (OR = 5.50, p < 0.001) and lower serum HDL-c concentrations (OR = 2.76, p = 0.004). After adjustment for confounders, the estimates did not change substantially, except for leptin for which the risk associated with overweight increased to 11.09 (95% CI: 4.05-30.35). In conclusion, excess body weight in adolescents exhibits strong associations with several markers that are established as causes of CVD in adults. This observation stresses the importance of primary prevention and of maintaining a healthy body weight throughout adolescence to reduce the global burden of CVD.

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Section: Discussionsupporting

confidence: 88%

Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents

Mastroeni

Gonçalves

et al. 2016

Appl. Physiol. Nutr. Metab.

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“…A study on NHANES 2001–2010 in 14,338 adults found that lower magnesium intake (from food and supplements) was associated with increased cardiometabolic risks, including elevated C -reactive protein (CRP) levels. CRP is a key inflammatory molecule that can adversely affect cardiometabolic health [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Intake, C-Reactive Protein, and Muscle Mass in Adolescents

et al. 2022

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Background: Adult studies have suggested that magnesium intake may regulate C-reactive protein (CRP) and muscle mass, known risk factors for cardiometabolic diseases. Given the large deficiencies in magnesium intake in adolescents, we aimed to investigate sex and race differences in dietary magnesium intake and test the hypothesis that lower magnesium intake is associated with higher CRP and lower muscle mass. Methods: A total of 766 black and white adolescents, 14 to 18 years old (51% black; 50% female) were previously recruited. Diet was assessed with four to seven independent 24-h recalls. Body composition was measured by dual-energy X-ray absorptiometry. High-sensitivity CRP (hs-CRP), leptin, resistin, and adiponectin were measured using fasting blood samples by ELISA. Results: There were sex and race differences in the daily consumption of magnesium. The average daily magnesium intakes were 200.66 ± 7.09 mg and 205.03 ± 7.05 mg for males and females, respectively, far below the recommended amounts of 410 mg for males and 360 mg for females. White subjects (217.95 ± 6.81 mg/day) consumed more than black subjects (187.75 ± 6.92 mg/day). Almost none of the adolescents met the recommendations. Adjusted multiple linear regressions revealed that lower magnesium intake was associated with higher hs-CRP and lower fat-free mass (FFM) (p-values < 0.05). Higher hs-CRP was associated with lower FFM. Moreover, an interaction between magnesium intake and hs-CRP on FFM was identified (p-value < 0.05). Lower magnesium intake amplified the inverse relationships between hs-CRP and FFM (p-values < 0.05). Conclusion: Magnesium consumption in our adolescents was far below daily recommended levels with male and black subjects consuming less than female and white subjects. Lower magnesium intake was associated with higher CRP and lower muscle mass. Low magnesium intake may also augment the inverse relationship between CRP and FFM.

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“…O aumento do consumo de alimentos com alto teor calórico e a diminuição da prática de atividade física contribuíram para o aumento da prevalência de sobrepeso e obesidade na população, especialmente em crianças e adolescentes, levando ao aparecimento de complicações precoces, como hipertensão arterial sistêmica, diabetes mellitus tipo 2, dislipidemia, apneia obstrutiva do sono e alguns tipos de câncer. Além disso, a obesidade tem um alto impacto nas doenças cardiovasculares, como a aterosclerose (CARDOSO et al, 2014).…”

Section: Introductionunclassified

Fatores de risco relacionados à obesidade em escolares atendidos em um ambulatório de pediatria

Chaves¹,

Freire²,

Neves³

et al. 2019

Acervo Saúde

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Objetivo: Identificar fatores de risco relacionados à obesidade em escolares atendidos em um ambulatório de pediatria e correlacioná-los. Métodos: Trata-se de um estudo observacional, transversal, com coleta sistematizada de dados acerca da prática de atividade física e níveis pressóricos dos escolares, além de dados antropométricos dos escolares e seus pais em um ambulatório de pediatria, no período de setembro a dezembro de 2015. Foram incluídas crianças na faixa etária escolar, de 5 a 12 anos exclusive de idade. Resultados: Observou-se uma prevalência de 38% de sobrepeso e 16% de obesidade. Quanto aos níveis pressóricos, 34% estavam dentro do percentil 50, 38% no percentil 90, 16% no percentil 95 e 12% no percentil 99 de pressão arterial. Quanto à atividade física, 86% foram classificados como ativos e 14% como inadequadamente ativos. Quanto à regularidade da prática da atividade física, 30% praticavam atividade física regularmente e 70% de forma irregular. Conclusão: A prevalência de obesidade infantil foi de 16% e 38% de sobrepeso. Não houve relação de obesidade com práticas de atividade física e IMC dos pais. Foi forte a relação entre obesidade e níveis pressóricos aumentados. Modificações do estilo de vida para prevenção e tratamento da obesidade são de grande importância para prevenir eventos cardiovasculares no futuro.

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C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cited by 3 publications

References 22 publications

Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents

Cardiometabolic risk markers of normal weight and excess body weight in Brazilian adolescents

Magnesium Intake, C-Reactive Protein, and Muscle Mass in Adolescents

Fatores de risco relacionados à obesidade em escolares atendidos em um ambulatório de pediatria

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