C-reactive Protein - A Phagocytosis-promoting Factor

Ganrot, P. O.; Kindmark, C.‐O.

doi:10.3109/00365516909080155

Cited by 46 publications

(15 citation statements)

References 4 publications

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“…There have been several reports on PSF. Of them, C-reactive protein [1], «2-HS glycoprotein |2] and phagocytosis-enhancing factor [3] are derived from serum proteins unrelated to the antibody and complement system. They are thought to enhance the phagocyto sis by neutrophils through their apparent ac tion on ingestible substances, while the tuft sin, liberated from a serum y-globulin frac tion, leucokinin, by leucokininase on plasma membrane of PMNs, is said to enhance the phagocytosis bv PMNs and macrophages through an action on the phagocytes [7, 11, 12J.…”

Section: Discussionmentioning

confidence: 99%

“…There have been reported phagocyto sis-promoting factors in the serum, which are distinguishable from antibody or com plement [1][2][3]. Recently, the role of the PMN product(s) as a regulator of inflamma tory response has been realized, and the chemotactic factor which is produced by PMNs during phagocytosis [4], the lyso zyme, a product of PMNs or monocytes, which modulates the chemotactic response of PMNs [5], the PMN-derived factor which enhances the DNA synthesis of anti gen-or mitogen-stimulated lymphocytes [6], have been reported respectively.…”

Section: Introductionmentioning

confidence: 99%

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Generation of a Phagocytosis-Stimulating Factor by Polymorphonuclear Neutrophils during Phagocytosis

Ishibashi¹,

Yamashita²

1981

Int Arch Allergy Immunol

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Polymorphonuclear neutrophils (PMNs) generated a phagocytosis-stimulating factor (PSF) intracellularly during phagocytosis of opsonized zymosan or latex particles. The generation of PSF by PMNs reached the maximum at 60 min after the start of phagocytosis. When PSF was washed out after preincubation with PMNs or opsonized zymosan particles, no enhancement of phagocytosis by PMNs was observed, suggesting that the continuous existence of PSF in the incubation medium is required for stimulation of phagocytosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Generation of a Phagocytosis-Stimulating Factor by Polymorphonuclear Neutrophils during Phagocytosis

Ishibashi¹,

Yamashita²

1981

Int Arch Allergy Immunol

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“…Functionally, CRP seems to be pluripotent, as it stimulates phagocytosis [12], inhibits production of cytotoxic lymphocytes [17], inhibits pokeweed mitogen, but not phytohemagglutinin-induced blastogeneses of human peripheral lymphocytes [11] as well as rosette formation of peripheral T lymphocytes [3] and it ac tivates complement [7,17]. CRP shows distant amino acids sequence homologies to the CH2 domain of IgG and C3a and close sequence homology to the 9.5S «-glycoprotein and P component of amyloid [16,19,21].…”

Section: Introductionmentioning

confidence: 99%

Reevaluation of C-Reactive Protein in Cancer Sera by Radioimmunoassay and Radial Immunodiffusion

Drahovský¹,

Dunzendorfer²,

Ziegenhagen³

et al. 1981

Oncology

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C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive method such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM staging and the disease activity at the time of determination. CRP shows a high degree of ‘uniqueness’ when correlated with other routinely used cancer markers such as carcinoembryonic antigen, placental-like alkaline phosphatase and γ-glutamyltranspeptidase.

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“…A modulatory role for the participation of C-rp in the promotion of neutrophil phagocytosis [1], activation of the classical pathway of complement [2], and platelet aggregation [3] has been demonstrated. In animal models of inflammation, rabbit C-reactive protein (Cx-rp) has been shown to bind to necrotic or altered cell membranes but not to normal cell membranes [4].…”

Section: Introductionmentioning

confidence: 99%

Exacerbation of experimental poly-d-lysine arthritis by C-reactive protein

1982

Agents and Actions

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Rabbit C-reactive protein (Cx-rp) was able to induce a prolonged exacerbation of inflammation when injected locally into arthritic rabbit knee joints. The increase in the level of inflammation, measured as the change in joint temperature, was accompanied by an increase in serum Cx-rp levels. Locally administered Cx-rp had no effect on joint swelling. Cx-rp, when injected locally into normal knee joints, had no effect on temperature or swelling. Cx-rp was unable to induce its own synthesis when injected intravenously into normal rabbits. The findings support a role for Cx-rp as a positive modulator of acute inflammation.

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C-reactive Protein - A Phagocytosis-promoting Factor

Cited by 46 publications

References 4 publications

Generation of a Phagocytosis-Stimulating Factor by Polymorphonuclear Neutrophils during Phagocytosis

Generation of a Phagocytosis-Stimulating Factor by Polymorphonuclear Neutrophils during Phagocytosis

Reevaluation of C-Reactive Protein in Cancer Sera by Radioimmunoassay and Radial Immunodiffusion

Exacerbation of experimental poly-d-lysine arthritis by C-reactive protein

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