“…In contrast, the C-terminus of B-Myb has a positive regulatory function (Oh and Reddy, 1998), since deletion of this region leads to a significant loss of the protein's transactivational activity. Additionally, use of the 32Dcl3 cell model system has shown that overexpression of these myb genes resulted in different phenotypes, that is, ectopic overexpression of cmyb blocked their terminal differentiation into granulocytes (Bies et al, 1995;Patel et al, 1996), while ectopic overexpression of either A-myb or B-myb failed to induce such a block Reddy, 1997, 1998).…”