c-kit-Immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions

Abstract

-kit-Immunopositive vascular progenitor cells populate human coronary in-stent restenosis but not primary atherosclerotic lesions.

SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells

“…42 In restenotic but not primary atherosclerotic lesions, c-kit ϩ cells positive for ␣-SMA are detectable, whereas c-kit Ϫ cells have not been analyzed. 23 We show that c-kit Ϫ /lin Ϫ /sca-1 ϩ cells and a subset expressing PDGFR-␤ ϩ preferentially expand in peripheral blood after wire-injury, differentiate into SMCs in response to PDGF-BB in vitro, and more readily undergo SDF-1␣-mediated recruitment and differentiation into neointimal SMCs than c-kit ϩ cells in vivo. This adds to the fundamental role of the PDGF system in neointimal SMC accumulation.…”

“…23,24 Several models of atherosclerosis have demonstrated that BM-derived or blood-borne progenitors to neointimal lesion formation give rise to a substantial proportion of neointimal cells in line with the severity of vascular injury. 5,6 The expression of SDF-1␣ has been implicated in neointima formation by mediating mobilization and recruitment of peripheral blood progenitor cells.…”

Stem Cells and Transplant Arteriosclerosis

“…However, they are often called "progenitor cells." 33,34 In accord, data from embryonic stem cells indicate that ECs and SMCs share the same progenitor. 35,36 In the present review, the term "stem cell" is used to describe more pluripotent cells, whereas "vascular progenitor cells" refer to the cells that can specifically differentiate into either ECs or SMCs, ie, EPCs and smooth muscle progenitors.…”

Extrahepatic and Intrahepatic Human Portal Interstitial Cajal Cells

“…as it was previously documented that CD34-positive stem cells in bone marrow express c-kit (Hibbert et al, 2004). CD34 monoclonal antibodies are known to label endothelial cells, mesenchymal cells and stroma fibrocytes functioning as matrix-producing cells (Leong et al, 2003;Pusztaszeri et al, 2006).…”