c-Kit (CD117) expression in classic Kaposi’s sarcoma

Kandemır, Nilüfer Onak; Gün, Banu Doğan; Bahadir, Burak; Yurdakan, Gamze; Ozdemir, Nagihan; Karadayi, Nimet; Özdamar, Şükrü Oğuz

doi:10.1111/j.1365-2230.2009.03661.x

Cited by 10 publications

(16 citation statements)

References 22 publications

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“…However, the number of KS cases in our study is similar to the study of Kandemir et al and both of the studies have got large population; therefore, both of the studies results' confirm each other. 8 Like Pantanowitz et al , we found that c-Kit expression was not linked to histopathological stage or tumor localization. 7 Unlike the other studies, the relapse rate for KS in our study was 15.6%.…”

Section: Discussionsupporting

confidence: 67%

“…They found that both c-Kit expression and immunostaining intensity were unrelated to histopathological stage. 8 In our study, out of 32 cases, c-Kit expression emerged in a range of 68.8%. In the three other studies, a low number of cases may lead to bias.…”

Section: Discussionsupporting

confidence: 45%

“…The extent of CD117 staining was accepted as -, no positive or < 1% positive cells;+, (10% of cells), ++, (>10and <50% of cells), and +++ (>50% of cells). 8 CD117 intensity was scored as 0 (none), 1+ (weak), 2+ (moderate) and 3+ (strong). 14 Nuclear staining in tumor cells was considered positive for Ki-67.…”

Section: Methodsmentioning

confidence: 99%

“…5 In the literature c-Kit expression has been investigated but different results have been reported. 6-8 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Şehitoğlu

Bedir

Cüre

et al. 2016

An. Bras. Dermatol.

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Backgroundc-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter.ObjectiveTo investigate c-Kit expression and intensity in patients with Kaposi's sarcoma (KS) and to investigate the relation between Ki-67 proliferation and MPV.MethodsA total of 32 patients, diagnosed with classic cutaneous KS, were included in this study. We reevaluated the histopathological reports with the preparations, confirmed the diagnosis and then determined the patients' histopathological stages. c-Kit expression and Ki-67 proliferation were investigated immunohistochemically in KS cases, while MPV in all cases was checked.ResultsAlthough c-Kit expression was detected in 22 cases (68.8%), it was not expressed in 10 cases (31.2%). We detected 8 cases with + (25%), 6 with ++ (18.8%) and 8 with +++ (25%). Ki-67 expression was 5.0% (min-max 1.0-20.0). Relapse was observed in 5 cases (15.6%) out of 32. There was positive correlation between c-Kit expression and MPV (rs=0.598, p<0.001), and between c-Kit intensity and MPV (rs=0.588, p<0.001).Conclusionc-Kit is highly positive in KS. c-Kit positivity indicates a high risk of tumor growth, invasion and relapse. Furthermore, c-Kit expression stimulates megakaryocytes to release young and large thrombocytes into the periphery. Thus, high MPV, c-Kit expression and immunostaining intensity indicate high invasion and relapse in KS subjects.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionsupporting

confidence: 45%

Section: Methodsmentioning

confidence: 99%

“…5 In the literature c-Kit expression has been investigated but different results have been reported. 6-8 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Şehitoğlu

Bedir

Cüre

et al. 2016

An. Bras. Dermatol.

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“…Although seminal advancements have been made regarding the understanding of the tumor, its histogenesis is still controversial. Some authors still consider that KS is a low-grade vascular tumor associated either with either HIV infection or immunosuppression [2], [3]. An important step was performed in the understanding of its etiology, with the evidence of the relation between human herpes virus 8 (HHV-8) and KS [4]; HHV-8 can be detected in the patient's blood 5–10 years before occurrence of the clinical symptoms [5].…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal-to-Endothelial Transition in Kaposi Sarcoma: A Histogenetic Hypothesis Based on a Case Series and Literature Review

et al. 2013

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ObjectivesAlthough several studies have been conducted regarding Kaposi sarcoma (KS), its histogenesis still remains to be elucidated. The aim of our study was to analyze the immunophenotype of Kaposi sarcoma and to present a hypothesis about the histogenesis of this tumor, based on a case series and a review of relevant literature.MethodsIn 15 cases of KSs diagnosed during 2000–2011, the clinicopathological features were correlated with the immunoexpression of c-Kit, SMA, CD34, CD31, vascular endothelial growth factor (VEGF), COX-2, c-KIT, smooth muscle antigen (SMA), and stem cell surface marker CD105.ResultsBoth CD105 and c-KIT rate of the spindle-shaped tumor cell positivity increased in parallel to the pathological stage. All cases displayed CD105 and weak c-KIT positivity in the endothelial cells. SMA, VEGF, and COX-2 were focally expressed in all cases. CD34 marked both endothelium and spindle-shaped tumor cells. No c-KIT expression was noticed in KS of the internal organs.ConclusionsKS seems to be a variant of myofibroblastic tumors that originates from the viral modified pluripotent mesenchymal cells of the connective tissue transformed in spindle-shaped KS cells, followed by a mesenchymal-endothelial transition and a myofibroblastic-like differentiation. This paper mailnly showed that KS cannot be considered a pure vascular tumor.

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Pulmonary Kaposi sarcoma in a patient with bilateral lung transplant: An unexpected diagnosis on transbronchial fine needle aspiration and core biopsy

Trabzonlu,

McDermott,

Pitman

et al. 2024

Diagnostic Cytopathology

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Kaposi sarcoma (KS) is a low‐grade vascular neoplasm that can be seen in various sites, most commonly seen in skin and mucosal tissues. Cytologic features of KS have been well‐documented in the literature, however, since it is rarely seen in visceral organs, it could pose significant diagnostic challenges on fine needle aspiration (FNA) biopsies. We present a case of pulmonary KS diagnosed on transbronchial FNA biopsy in a 70‐year‐old female bilateral lung allograft recipient 11 months after transplantation. The aspirate smears showed a moderately cellular specimen containing a mixture of small, tightly cohesive clusters and loosely clustered groups of monomorphic, ovoid to spindled cells with moderate nuclear to cytoplasmic ratio. An extensive immunohistochemical panel on the concurrent core biopsy showed the tumor cells to be positive for ERG, KIT, and HHV8, confirming the diagnosis. We compared our case to previously published reports of confirmed pulmonary KS in lung allograft recipients.

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c-Kit (CD117) expression in classic Kaposi’s sarcoma

Abstract: The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.

Cited by 10 publications

References 22 publications

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Mesenchymal-to-Endothelial Transition in Kaposi Sarcoma: A Histogenetic Hypothesis Based on a Case Series and Literature Review

Pulmonary Kaposi sarcoma in a patient with bilateral lung transplant: An unexpected diagnosis on transbronchial fine needle aspiration and core biopsy

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