C H functionalization of (hetero)arenes: Direct selanylation mediated by Selectfluor

Belladona, Andrei L.; Cervo, Rodrigo; Alves, Diego; Barcellos, Thiago; Cargnelutti, Roberta; Schumacher, Ricardo F.

doi:10.1016/j.tetlet.2020.152035

Cited by 22 publications

(12 citation statements)

References 47 publications

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“…The concept of activation of organodiselenides by selectuor was further applied by the same author towards the C-H selenation of heteroarenes and electron rich aromatic compounds (Scheme 32). 48 The reactions were performed under air in room temperature in acetonitrile solvent. A large array of heteroarenes such as, imidazo[2,1-b]thiazole, imidazo[2,1-b]pyridine, indole, pyrazole, thiazole etc.…”

Section: Under Conventional Methodsmentioning

confidence: 99%

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Synthetic strategies for aryl/heterocyclic selenides and tellurides under transition-metal-catalyst free conditions

Kundu

2021

RSC Adv.

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Section: Under Conventional Methodsmentioning

confidence: 99%

“…The concept of activation of organodiselenides by selectfluor was further applied by the same author towards the C–H selenation of heteroarenes and electron rich aromatic compounds ( Scheme 32 ). 48 …”

Section: Under Conventional Methodsmentioning

confidence: 99%

Synthetic strategies for aryl/heterocyclic selenides and tellurides under transition-metal-catalyst free conditions

Kundu

2021

RSC Adv.

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“…This highlighted the significance of incorporating selenium into pyrazole motifs. Belladona et al reported a direct C-H selanylation of pyrazoles with Selectfluor ( N -chloromethyl- N -fluorotriethylenediammonium bis(tetrafluoroborate)), a stable and commercially available oxidant, to afford 4-phenylselenol substituted pyrazole derivatives [ 68 ]. The reaction was triggered by the interaction of diphenyl selenide with Selectfluor to form electrophilic selanyl species, which were then attacked by nucleophilic pyrazole substrates to give the final product.…”

Section: The Functionalization Of Pyrazolesmentioning

confidence: 99%

Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020)

2021

Molecules

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The remarkable prevalence of pyrazole scaffolds in a versatile array of bioactive molecules ranging from apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to bixafen, a pyrazole-carboxamide fungicide used to control diseases of rapeseed and cereal plants, has encouraged both medicinal and organic chemists to explore new methods in developing pyrazole-containing compounds for different applications. Although numerous synthetic strategies have been developed in the last 10 years, there has not been a comprehensive overview of synthesis and the implication of recent advances for treating neurodegenerative disease. This review first presents the advances in pyrazole scaffold synthesis and their functionalization that have been published during the last decade (2011–2020). We then narrow the focus to the application of these strategies in the development of therapeutics for neurodegenerative diseases, particularly for Alzheimer’s disease (AD) and Parkinson’s disease (PD).

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“…However, in many cases the use of external oxidants or catalysts is required. [27][28][29][30][31][32][33][34] Electrochemistry, on the other hand, is an ally of sustainable chemistry, and is applied in several areas, including environmental monitoring, effluent treatment, energy storage and industrial applications. [35][36][37][38][39] It is a powerful method for the synthesis of complex organic molecules, [40,41] generally with high chemoselectivity and conducted under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

Versatile Electrochemical Oxidative C(sp₂)−H Bond Selenylation of Resveratrol

et al. 2021

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A simple and environmentally benign procedure for electrochemical oxidative mono-and bis-selenylation of the resveratrol C(sp 2 )À H bond was developed. Driven by galvanostatic electrolysis in an undivided cell, it provided efficient transformation under oxidant-, base-, and transition metal-free conditions, in an open system at room temperature. With satisfactory functional group compatibility, it required a substoichiometric amount of NaI, which acted as an electrolyte and mediator.

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C H functionalization of (hetero)arenes: Direct selanylation mediated by Selectfluor

Cited by 22 publications

References 47 publications

Synthetic strategies for aryl/heterocyclic selenides and tellurides under transition-metal-catalyst free conditions

Synthetic strategies for aryl/heterocyclic selenides and tellurides under transition-metal-catalyst free conditions

Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020)

Versatile Electrochemical Oxidative C(sp₂)−H Bond Selenylation of Resveratrol

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C H functionalization of (hetero)arenes: Direct selanylation mediated by Selectfluor

Cited by 22 publications

References 47 publications

Synthetic strategies for aryl/heterocyclic selenides and tellurides under transition-metal-catalyst free conditions

Synthetic strategies for aryl/heterocyclic selenides and tellurides under transition-metal-catalyst free conditions

Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer’s Disease and Parkinson’s Disease Treatment (2011–2020)

Versatile Electrochemical Oxidative C(sp2)−H Bond Selenylation of Resveratrol

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Versatile Electrochemical Oxidative C(sp₂)−H Bond Selenylation of Resveratrol