C/EBPβ converts bovine fibroblasts to adipocytes without hormone cocktail induction

Chen, Gong; Raza, Sayed Haidar Abbas; Khan, Rajwali; Wang, Hong; Shater, Abdullah F.; Mohammedsaleh, Zuhair M.; Wang, Li; Tian, Yuan; Long, Feng; Liu, Zan

doi:10.1016/j.ejbt.2021.04.008

Cited by 4 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C/EBP plays a crucial function in the early adipocyte development process. Through the stimulation of adipocyte‐specific genes and lipogenic pathways, it strengthens adipogenesis in a mutually beneficial positive feedback loop with PPAR (Cheng et al., 2021; Darlington et al., 1998; Hishida et al., 2009; Rosen & MacDougald, 2006). SREBP‐1c is in charge of controlling the expression of lipogenic genes in beef cattle.…”

Section: Metabolic Signalling Pathwaysmentioning

confidence: 99%

A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

Abebe,

Wang,

et al. 2023

J Animal Breeding Genetics

Self Cite

View full text Add to dashboard Cite

In the past few decades, genomic selection and other refined strategies have been used to increase the growth rate and lean meat production of beef cattle. Nevertheless, the fast growth rates of cattle breeds are often accompanied by a reduction in intramuscular fat (IMF) deposition, impairing meat quality. Transcription factors play vital roles in regulating adipogenesis and lipogenesis in beef cattle. Meanwhile, understanding the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle has gained significant attention to increase IMF deposition and meat quality. Therefore, the aim of this paper was to provide a comprehensive summary and valuable insight into the complex role of transcription factors in adipogenesis and lipogenesis in beef cattle. This review summarizes the contemporary studies in transcription factors in adipogenesis and lipogenesis, genome‐wide analysis of transcription factors, epigenetic regulation of transcription factors, nutritional regulation of transcription factors, metabolic signalling pathways, functional genomics methods, transcriptomic profiling of adipose tissues, transcription factors and meat quality and comparative genomics with other livestock species. In conclusion, transcription factors play a crucial role in promoting adipocyte development and fatty acid biosynthesis in beef cattle. They control adipose tissue formation and metabolism, thereby improving meat quality and maintaining metabolic balance. Understanding the processes by which these transcription factors regulate adipose tissue deposition and lipid metabolism will simplify the development of marbling or IMF composition in beef cattle.

show abstract

Section: Metabolic Signalling Pathwaysmentioning

confidence: 99%

A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

Abebe,

Wang,

et al. 2023

J Animal Breeding Genetics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Adipogenic differentiation occurs through a series of stages, in which multipotent stem cells (MSCs) are transformed to mature adipocytes [ 6 ]. Initially, MSCs are converted into preadipocytes for adipogenic differentiation, followed by clonal expansion, CCAAT-enhancer-binding protein beta (C/EBPβ) expression, and accumulation of lipid droplets [ 7 ]. Subsequently, peroxisome proliferator-activated receptor-gamma (PPARγ) and CCAAT-enhancer-binding protein beta (C/EBPα) are expressed, resulting in lipogenesis, during which the lipid droplet size increases [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats

Lee

Chae

et al. 2022

Nutrients

View full text Add to dashboard Cite

Akebia quinata, commonly called chocolate vine, has various bioactivities, including antioxidant and anti-obesity properties. However, the anti-obesity effects of bioconverted extracts of A. quinate have not been examined. In this study, A. quinata fruit extracts was bioconverted using the enzyme isolated from the soybean paste fungi Aspergillus kawachii. To determine whether the bioconversion process could influence the anti-obesity effects of A. quinata fruit extracts, we employed 3T3-L1 adipocytes and HFD-induced obese rats. We observed that the bioconverted fruit extract of A. quinata (BFE) afforded anti-obesity effects, which were stronger than that for the non-bioconverted fruit extract (FE) of A. quinata. In 3T3-L1 adipocytes, treatment with BFE at concentrations of 20 and 40 μg reduced intracellular lipids by 74.8 (p < 0.05) and 54.9% (p < 0.01), respectively, without inducing cytotoxicity in preadipocytes. Moreover, the oral administration of BFE at the concentration of 300 mg/kg/day significantly reduced body and adipose tissue weights (p < 0.01) in HFD-induced obese rats. Plasma cholesterol values were reduced, whereas HDL was increased in BFE receiving rats. Although FE could exert anti-obesity effects, BFE supplementation induced more robust effects than FE. These results could be attributed to the bioconversion-induced alteration of bioactive compound content within the extract.

show abstract

Research progress of non-coding RNAs regulation on intramuscular adipocytes in domestic animals

Gong

Lin

Wang

et al. 2023

Gene

View full text Add to dashboard Cite

C/EBPβ converts bovine fibroblasts to adipocytes without hormone cocktail induction

Cited by 4 publications

References 47 publications

A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle

Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats

Research progress of non-coding RNAs regulation on intramuscular adipocytes in domestic animals

Contact Info

Product

Resources

About