C-C Chemokines in the Vitreous of Patients With Proliferative Vitreoretinopathy and Proliferative Diabetic Retinopathy

Capeáns, C.; Mv, De Rojas; Lojo, S; Ms, Salorio

doi:10.1097/00006982-199806000-00009

Cited by 46 publications

(47 citation statements)

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“…Neutralizing antibodies against MCP-1 reduced retinal neovascularization [32]. Our results of increased levels of MCP-1 in the vitreous humor samples from patients with PVR or with PDR are consistent with previous reports [4][5][6]. Furthermore, we found that MCP-1 levels in vitreous humor samples from active PDR cases were significantly higher than those in inactive PDR cases.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies of epiretinal membranes showed the presence of activated T lymphocytes, B lymphocytes, and macrophages [1][2][3]. The specific mediators that orchestrate the recruitment of leukocytes leading to proliferative vitreoretinal disorders have not been fully elucidated, although several studies demonstrated elevated levels of several chemokines in vitreous humour removed from patients with proliferative vitreoretinal disorders [4][5][6][7][8]. In addition, it has been demonstrated that angiogenic growth factors, such as vascular endothelial growth factor (VEGF) play an important role in mediating ischemiainduced retinal neovascularization in PDR [9].…”

mentioning

confidence: 99%

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Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

Asrar

Struyf

Kangave

et al. 2008

Acta Ophthalmologica

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

Asrar

Struyf

Kangave

et al. 2008

Acta Ophthalmologica

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“…Vitreous samples from patients with RD contain significantly higher levels of MCP-1 than samples from patients with other retinal conditions, such as macular hole or idiopathic premacular fibrosis (18,19). The MCP-1 receptor CCR2 is expressed on leukocytes, endothelium (20), glial cells, and neurons in the brain (21).…”

mentioning

confidence: 99%

Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis

Nakazawa

Hisatomi

Nakazawa

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

252

260

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“…In addition, patients who needed reoperation because of TRD had particularly high MCP-1 levels at all periods examined. Although previous reports have already revealed that the MCP-1 level in the vitreous with proliferative vitreoretinopathy, retinal detachment, and PDR was significantly higher compared with that in idiopathic epiretinal membrane, [14][15][16] this is the first report showing that the MCP-1 level in TRD after vitreous surgery was significantly elevated. In Figure 4b, bold horizontal broken lines and fine broken lines indicated the mean and mean+SD levels of MCP-1 at first surgery, respectively.…”

Section: Discussionmentioning

confidence: 55%

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

Sassa

Ishikawa

Asato

et al. 2016

Eye

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Purpose To determine whether the concentrations of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein (MCP)-1 in the vitreous changed after vitrectomy in patients with proliferative diabetic retinopathy (PDR). Participants Twenty-one eyes of 21 patients who needed a second surgery for PDR were included. The reasons for the second surgery were tractional retinal detachment (TRD), neovascular glaucoma, persistent vitreous hemorrhage, macular pucker, and secondary intraocular lens (IOL) implant. Methods We measured the VEGF and MCP-1 levels using sandwich enzyme-linked immunosorbent assays in vitreous samples collected from patients with PDR before pars plana vitrectomy (without IOL implantation), and from the same patients during the second surgery. Results There was not significant change in mean VEGF concentrations when comparing first (0.81 ± 0.88 ng/ml) and second surgeries (1.09 ± 1.51 ng/ml). The MCP-1 level was significantly elevated at the time of second surgery (2.20 ± 2.21 ng/ml) compared with the first vitrectomy (0.72 ± 0.57 ng/ml). The MCP-1 levels of the second surgery cases with TRD (3.18 ± 2.27 ng/ml) increased significantly compared with those with other complications (1.72 ± 2.10 ng/ml). Conclusions At the second vitrectomy, VEGF did not change significantly in the vitreous of the patients examined. The MCP-1 concentration was markedly elevated at the second vitrectomy, implying an association between the prolonged inflammation after vitrectomy and complications, especially TRD.

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C-C Chemokines in the Vitreous of Patients With Proliferative Vitreoretinopathy and Proliferative Diabetic Retinopathy

Cited by 46 publications

References 0 publications

Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis

The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy

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