C. butyricum lipoteichoic acid inhibits the inflammatory response and apoptosis in HT-29 cells induced by S. aureus lipoteichoic acid

Wang, Jinbo; Qi, Lili; Mei, Lehe; Wu, Zhongqi; Wang, Hengzheng

doi:10.1016/j.ijbiomac.2016.03.054

Cited by 19 publications

(16 citation statements)

References 27 publications

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“…Moreover, C. butyricum effectively inhibited ETEC K88-induced increase in IL-1b and IL-18, while also enhancing ETEC K88-induced increases in IL-10. These results are consistent with previous reports that C. butyricum has anti-inflammatory effects by downregulating IL-8 and TNF-a production (Chen et al 2010;Wang et al 2016) or upregulating IL-10 production in inflammation (Hayashi et al 2013). Thus, in this current study, feeding pigs with C. butyricum diet may improve intestinal integrity partially by inhibiting pro-inflammatory cytokine production or promoting the expression of anti-inflammatory cytokine.…”

Section: Discussionsupporting

confidence: 93%

Dietary supplementation with Clostridium butyricum helps to improve the intestinal barrier function of weaned piglets challenged with enterotoxigenic Escherichia coli K88

Zhu

et al. 2018

J Appl Microbiol

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Section: Discussionsupporting

confidence: 93%

Dietary supplementation with Clostridium butyricum helps to improve the intestinal barrier function of weaned piglets challenged with enterotoxigenic Escherichia coli K88

Zhu

et al. 2018

J Appl Microbiol

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“…butyricum might be related to lipoteichoic acid (LTA). LTA is a major cell wall component of gram-positive bacteria [75,76]. In human, the classical complement pathway is activated by LTA in vitro [77].…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus)

Zhou²,

Ling³

et al. 2019

PLoS ONE

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This study was conducted to assess the effects of dietary Clostridium butyricum on the growth, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus). Three hundreds of tilapia (56.21 ± 0.81 g) were divided into 5 groups and fed a diet supplemented with C. butyricum at 0, 1 x 104, 1 x 105, 1 x 106 or 1 x 107 CFU g-1 diet (denoted as CG, CB1, CB2, CB3 and CB4, respectively) for 56 days. Then 45 fish from each group were intraperitoneally injected with Streptococcus agalactiae, and the mortality was recorded for 14 days. The results showed that dietary C. butyricum significantly improved the specific growth rate (SGR) and feed intake in the CB2 group and decreased the cumulative mortality post-challenge with S. agalactiae in the CB2, CB3 and CB4 groups. The serum total antioxidant capacity and intestinal interleukin receptor-associated kinase-4 gene expression were significantly increased, and serum malondialdehyde content and diamine oxidase activity were significantly decreased in the CB1, CB2, CB3 and CB4 groups. Serum complement 3 and complement 4 concentrations and intestinal gene expression of tumour necrosis factor α, interleukin 8, and myeloid differentiation factor 88 were significantly higher in the CB2, CB3 and CB4 groups. Intestinal toll-like receptor 2 gene expression was significantly upregulated in the CB3 and CB4 groups. Dietary C. butyricum increased the diversity of the intestinal microbiota and the relative abundance of beneficial bacteria (such as Bacillus), and decreased the relative abundance of opportunistic pathogenic bacteria (such as Aeromonas) in the CB2 group. These results revealed that dietary C. butyricum at a suitable dose enhanced growth performance, elevated humoral and intestinal immunity, regulated the intestinal microbial components, and improved disease resistance in tilapia. The optimal dose was 1 x 105 CFU g-1 diet.

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“…Specifically, CBM 588 lipoteichoic acid (LTA) has been shown to modulate TLR2 signaling and suppress pathogen-induced inflammation and apoptosis in vitro. 63,64 Thus, C. butyricum promotes an anti-inflammatory Treg response by induction of IL-10 and TGF-β, possibly through activation of a TLR2-dependent pathway (Figure 3). C. butyricum has been shown to suppress Th1 and Th17 mediated inflammations, presumably via the increased Treg response (Figure 3).…”

Section: Butyricum Restores Immune Homeostasis By Promoting Treg Responsesmentioning

confidence: 99%

Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease

Stoeva¹,

Garcia-So²,

Justice³

et al. 2021

Gut Microbes

206

156

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Clostridium butyricum is a butyrate-producing human gut symbiont that has been safely used as a probiotic for decades. C. butyricum strains have been investigated for potential protective or ameliorative effects in a wide range of human diseases, including gut-acquired infection, intestinal injury, irritable bowel syndrome, inflammatory bowel disease, neurodegenerative disease, metabolic disease, and colorectal cancer. In this review we summarize the studies on C. butyricum supplementation with special attention to proposed mechanisms for the associated health benefits and the supporting experimental evidence. These mechanisms center on molecular signals (especially butyrate) as well as immunological signals in the digestive system that cascade well beyond the gut to the liver, adipose tissue, brain, and more. The safety of probiotic C. butyricum strains appears well-established. We identify areas where additional human randomized controlled trials would provide valuable further data related to the strains' utility as an intervention.

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C. butyricum lipoteichoic acid inhibits the inflammatory response and apoptosis in HT-29 cells induced by S. aureus lipoteichoic acid

Cited by 19 publications

References 27 publications

Dietary supplementation with Clostridium butyricum helps to improve the intestinal barrier function of weaned piglets challenged with enterotoxigenic Escherichia coli K88

Dietary supplementation with Clostridium butyricum helps to improve the intestinal barrier function of weaned piglets challenged with enterotoxigenic Escherichia coli K88

The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus)

Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease

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