C-11 Choline PET/CT Imaging for Differentiating Malignant From Benign Prostate Lesions

Abstract

FDG PET-CT imaging is increasingly accepted as a modality for evaluation of many malignancies, but FDG also can be accumulated intensely by inflammatory lesions. We present a case of a 60-year-old woman with intermittent fever, chills, fatigue, and dyschezia. CT scans indicated colon carcinoma with thoracic and retroperitoneal lymph node metastases. Whole body FDG PET-CT was performed to confirm and stage the malignant disease and showed intense FDG uptake in those lesions. However, histopathology confirmed tuberculosis. The literature describing FDG accumulation in constitutional tuberculous lesions is sparse, and one must be aware of patterns of FDG accumulation in tuberculosis in the diagnosing malignancies.

Imaging of organ-confined prostate cancer: functional ultrasound, MRI and PET/computed tomography

“…Using 11 C-choline to detect prostate cancer, published sensitivities and specificities vary a lot according to studies [66][67][68][69], between 55 and 90% for sensitivity and between 43 and 86% for specificity. Possible reasons for these discrepancies could be differences in analysis (per patient vs. per sextant), small number of studied patients and, as pointed out by Reske [70], a decrease in 11 C-choline uptake related to hormonotherapy.…”

4-11C-Methoxy N-(2-Diethylaminoethyl) Benzamide: A Novel Probe to Selectively Target Melanoma

“…For the internalization experiments (23,24), the cells were treated with a low pH buffer to sequester membrane-bound radioactivity from the internalized fraction. Although the overall binding to cells increased with increased density of cells, the internalized fraction remained approximately 60% of the total cell-associated radioactivity irrespective of the cell density (Fig.…”

Current status of choline‐PET and prostate cancer

“…A sensitivity/specificity of 90/86 per cent has been reported for the detection of localised prostatic malignancy, 7 but this is dependent on the size of the lesion. 8 Others have reported that choline uptake corresponded to histological localisation of the tumour in fewer than 50 per cent of cases, with a great deal of interpatient variability.…”