Imaging of organ-confined prostate cancer: functional ultrasound, MRI and PET/computed tomography

Puech, Philippe; Huglo, D.; Petyt, G.; Lemaître, L.; Villers, Arnauld

doi:10.1097/mou.0b013e328323f5ed

Cited by 52 publications

(29 citation statements)

References 81 publications

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“…This type of MRI is performed by injecting a gadolinium based contrast agent into the patient and measuring the signal intensity on T1 weighted images. Areas of increased angiogenesis, such as prostate cancer, will have increased enhancement on T1 weighted images [Puech et al 2009;Kurhanewicz et al 2008]. A recent study showed that DCE MRI has a 89% sensitivity and 90% specificity for localizing prostate cancer [Crawford and Barqawi, 2007].…”

Section: Future Direction Of Researchmentioning

confidence: 99%

“…A minimum of six weeks is required between the prostate biopsy and the MRI. Prostatic hemorrhage after biopsy can cause artifact that will overestimate the amount of cancer on the MRI [Puech et al 2009;Zelhof et al 2009;Kurhanewicz et al 2008].…”

Section: Future Direction Of Researchmentioning

confidence: 99%

“…inflammation and BPH) can cause decreased specificity of the MRI techniques [Puech et al 2009;Zelhof et al,. 2009;Kurhanewicz et al 2008].…”

Section: Future Direction Of Researchmentioning

confidence: 99%

“…The specificity of localization of prostate cancer with the combined exams increases to 98% when a sextant biopsy is positive [Kurhanewicz et al 2008]. The sensitivity and specificity of the MRI techniques increases with higher volume and grade prostate cancer [Puech et al 2009]. …”

Section: Future Direction Of Researchmentioning

confidence: 99%

“…The MRSI detects elevations and depressions in certain metabolites that are present in tissues with prostate cancer but not in normal tissues. Evaluation of the data produced by the MRSI needs to be processed by special software which makes access to this modality limited [Puech et al 2009;Kurhanewicz et al 2008].…”

Section: Future Direction Of Researchmentioning

confidence: 99%

See 4 more Smart Citations

Targeted focal therapy for prostate cancer: a review of the literature

Sullivan

Crawford

2009

Therapeutic Advances in Urology

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Improvements in prostate cancer diagnosis and treatment have resulted in a decreasing age-adjusted death rate. But improved diagnostic tools have not delivered a proportionate decrease in mortality, primarily because physicians now are diagnosing and treating more clinically insignificant tumors. Targeted focal therapy (TFT) uses three dimensional (3D) mapping biopsies to guide cryotherapy so that it targets lesions themselves while sparing surrounding healthy tissues, thereby avoiding side effects associated with more invasive treatments. As such, TFT can provide a bridge between active surveillance and more aggressive treatments for patients with low-risk tumors. It is appropriate for men who either do not want or are not good candidates for more aggressive therapies. Identifying patients who are appropriate candidates for TFT is challenging, but the mapping biopsy technique helps identify individuals who have localized disease and could benefit from this treatment. In recent years, improvements in cryotherapy have increased its efficacy while decreasing complications. At the present time using cryotherapy to target and destroy the cancer(s) is appealing. Other approaches to less aggressive therapies are discussed including gland hemi ablation, high intensity ultrasound (HIFU) and others. Going forward, patients will benefit further from development of better imaging technologies and completion of long-term survival studies.

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Section: Future Direction Of Researchmentioning

confidence: 99%

Section: Future Direction Of Researchmentioning

confidence: 99%

“…inflammation and BPH) can cause decreased specificity of the MRI techniques [Puech et al 2009;Zelhof et al,. 2009;Kurhanewicz et al 2008].…”

Section: Future Direction Of Researchmentioning

confidence: 99%

Section: Future Direction Of Researchmentioning

confidence: 99%

Section: Future Direction Of Researchmentioning

confidence: 99%