By-passing the sphincter of Oddi does not affect gallbladder emptying in the pig

Abstract

Summary. A study of the relationship between bile secretion and nutrition in the pig requires a complete and continuous collection of the bile and its reinfusion to the animal. In most of the studies performed in different species, bile has been directly reinfused into the duodenum, leading to the exclusion of the sphincter of Oddi from the biliary pathway. It has been postulated that such an exclusion could inhibit gallbladder emptying. The aim of the present work was to study postprandial gallbladder emptying in the pig, depending on the site of bile reinfusion, i.e. the duodenum or the lower bile duct. The gallbladder bile was coloured with indocyanine green (ICG) and marker secretion was recorded after a testmeal. The results showed that after meal intake, the gallbladder emptied over a similar period of time and according to similar kinetics, whatever the site of bile reinfusion.Introduction.

Bile secretion in the fistulated pig : effect of the method used for bile reinfusion

“…In this connection, the daily amount of bile acids passing through the enterohepatic circulation of the rat, when the bile was selfreturned into the common bile duct (Weis and Barth, 1978) (Egger et al, 1974), has to be ruled out for it has been shown to empty according to the same kinetics, whatever the site of bile infusion (duodenum or lower bile duct) when the automatic apparatus is used (Jimenez, Juste and Corring, 1983). Moreover, the gallbladder of the pig empties within the first hour after meal consumption (Laplace, 1976;Jimenez, Juste and Corring, 1983), whereas the results presented here show that whatever period was studied (first or second postprandial or nocturnal), bile acid concentration was about 16 to 23.5 % higher when the bile was automatically reinfused into the lower bile duct than when it was infused by any other means. We suggest that another step of the enterohepatic circulation must have been implicated.…”