Butyrolactone

Schwarz, Wolfgang; Schossig, Jürgen; Rossbacher, Roland; Höke, Hartmut

doi:10.1002/14356007.a04_495

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Pyrrolidones are molecules with a wide variety of applications as surfactants, solvents, and intermediates in the synthesis of pharmaceutical and bioactive compounds. − They are also included in the formulation of cleaning products and aerosols and are also useful as ink …”

Section: Multistep Sequential Processes On Single-site Solid Catalystsmentioning

confidence: 99%

Heterogeneous Catalysis for Tandem Reactions

et al. 2014

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Section: Multistep Sequential Processes On Single-site Solid Catalystsmentioning

confidence: 99%

Heterogeneous Catalysis for Tandem Reactions

et al. 2014

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“…γ-Butyrolactone ( 78 , GBL) is an important bulk chemical, mainly used as precursor for the preparation of pyrrolidones and as solvent. It is currently synthesized at a commercial scale from the catalytic dehydrogenation of 1,4-BDO or from the catalytic reduction of maleic anhydride . The dehydrogenation of 1,4-BDO in continuous flow reactors was studied on copper-based catalysts − and on a Re cluster .…”

Section: Upgrading Of Polyolsmentioning

confidence: 99%

Continuous Flow Upgrading of Selected C₂–C₆Platform Chemicals Derived from Biomass

et al. 2020

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The ever increasing industrial production of commodity and specialty chemicals inexorably depletes the finite primary fossil resources available on Earth. The forecast of population growth over the next 3 decades is a very strong incentive for the identification of alternative primary resources other than petro-based ones. In contrast with fossil resources, renewable biomass is a virtually inexhaustible reservoir of chemical building blocks. Shifting the current industrial paradigm from almost exclusively petro-based resources to alternative bio-based raw materials requires more than vibrant political messages; it requires a profound revision of the concepts and technologies on which industrial chemical processes rely. Only a small fraction of molecules extracted from biomass bears significant chemical and commercial potentials to be considered as ubiquitous chemical platforms upon which a new, bio-based industry can thrive. Owing to its inherent assets in terms of unique process experience, scalability, and reduced environmental footprint, flow chemistry arguably has a major role to play in this context. This review covers a selection of C2 to C6 bio-based chemical platforms with existing commercial markets including polyols (ethylene glycol, 1,2-propanediol, 1,3-propanediol, glycerol, 1,4-butanediol, xylitol, and sorbitol), furanoids (furfural and 5-hydroxymethylfurfural) and carboxylic acids (lactic acid, succinic acid, fumaric acid, malic acid, itaconic acid, and levulinic acid). The aim of this review is to illustrate the various aspects of upgrading bio-based platform molecules toward commodity or specialty chemicals using new process concepts that fall under the umbrella of continuous flow technology and that could change the future perspectives of biorefineries.

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“…For example, the partition coefficients of 4-HB and GBL between octanol and water are only 0.4 and 0.23, respectively (http://www.syrres.com). In-situ removal of GBL by evaporation is also not a feasible option due to the high boiling point of GBL (204-2058C) and low vapor pressure (0.15 and 1.07 kPa at 20 and 608C, respectively; Schwarz et al, 2005). Since GBL is a liquid completely miscible with water, removal by precipitation is not feasible either.…”

Section: Process Feasibilitymentioning

confidence: 99%

“…Other hypothetical options that might be studied in the future are in-situ chemocatalytic hydrogenation to 1,4-butanediol or tetrahydrofuran (Schwarz et al, 2005).…”

Section: Process Feasibilitymentioning

confidence: 99%

Options for biochemical production of 4‐hydroxybutyrate and its lactone as a substitute for petrochemical production

Efe

Straathof

Wielen

2007

Biotech & Bioengineering

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Options are discussed for biochemical production of 4-hydroxybutyrate (4-HB) and its lactone, gamma-butyrolactone (GBL), from renewable sources. In the first part of the study, the thermodynamic feasibility of four potential metabolic pathways from glucose to 4-HB are analyzed. The calculations reveal that when the pathways are NAD(+) dependent the intermediate succinate semialdehyde (SSA) accumulates leading to low 4-HB yields at equilibrium. For NADP(+) dependent pathways the calculated yield of 4-HB improves, up to almost 100%. In the second part of this study, continuous removal of 4-HB from the solution is considered to shift SSA conversion into 4-HB so that SSA accumulation is minimized. One option is the enzymatic production of GBL from 4-HB. Candida antarctica Lipase B shows good lactonization rates at pH 4, but unfortunately this conversion cannot be performed in-vivo during 4-HB production because of the neutral intracellular pH.

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Butyrolactone

Abstract: The article contains sections titled: 1. Introduction 2. Physical Properties … Show more

Cited by 10 publications

References 22 publications

Heterogeneous Catalysis for Tandem Reactions

Heterogeneous Catalysis for Tandem Reactions

Continuous Flow Upgrading of Selected C₂–C₆Platform Chemicals Derived from Biomass

Options for biochemical production of 4‐hydroxybutyrate and its lactone as a substitute for petrochemical production

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Butyrolactone

Abstract: The article contains sections titled: 1. Introduction 2. Physical Properties … Show more

Cited by 10 publications

References 22 publications

Heterogeneous Catalysis for Tandem Reactions

Heterogeneous Catalysis for Tandem Reactions

Continuous Flow Upgrading of Selected C2–C6Platform Chemicals Derived from Biomass

Options for biochemical production of 4‐hydroxybutyrate and its lactone as a substitute for petrochemical production

Contact Info

Product

Resources

About

Continuous Flow Upgrading of Selected C₂–C₆Platform Chemicals Derived from Biomass