Butyrate mediated regulation of RNA binding proteins in the post-transcriptional regulation of inflammatory gene expression

Torun, Aydan; Enayat, Shabnam; Sheraj, Ilir; Tunçer, Sinem; Ülgen, Doğukan Hazar; Banerjee, Sreeparna

doi:10.1016/j.cellsig.2019.109410

Cited by 22 publications

(15 citation statements)

References 55 publications

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“…Accounting for 7.5% of about 20,500 protein-coding genes in humans [8], RBPs blind to RNA, or constitute crucial components of ribonucleoprotein (RNPs) to participate in RNA metabolism [9]. Till now, genome-wide screening of the human genome has identified more than 1,500 RBPs that played an essential role in biogenesis, surveillance, transport, localization and degradation of RNA in line with the genetic and biochemical studies [8,[10][11][12].…”

Section: Introductionmentioning

confidence: 93%

Six RNA binding proteins (RBPs) related prognostic model predicts overall survival for clear cell renal cell carcinoma and it is associated with immune infiltration

Xing

Luan

Liu

et al. 2021

Bosn J of Basic Med Sci

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The aim of this article was to construct an accurate prognostic model by using RNA-binding proteins (RBPs) to predict overall survival (OS) for patients with clear cell renal cell carcinoma (ccRCC) as well as to reveal its associations with immune infiltration. Expression profiles based on RNA-binding proteins (RBPs) and clinical follow-up parameters were obtained from the Cancer Genome Atlas (TCGA) and the ArrayExpress databases. Through univariate COX and LASSO regression analyses, the RBPs based signature was developed. A total of six RBPs (CLK2, IGF2BP2, RNASE2, EZH2, PABPC1L, RPL22L1) were eventually used to establish a prognostic signature. Based on this signature, ccRCC patients were classified into high-risk and low-risk subgroups and significant OS was obtained in both the internal and external datasets (p<0.05). AUCs of its ROC curve were all above 0.70 and this signature was an independent prognostic factor of OS for ccRCC (p<0.05). Nomograms were also constructed to visualize the relationships among individual predictors and 1-, 3- and 5-year OS for ccRCC. Furthermore, the established RBPs based signature was strongly related to critical clinicopathologic characteristics such as grade (p=8.921e−12), stage (p=1.421e−11), M (p=1.662e−05), and T stage (p=7.907e−10). Moreover, 12 kinds of tumor-infiltrating immune cells were significantly linked to high-risk and low-risk groups classified by our constructed model (all p<0.05). Our study successfully identified six RBPs as a robust prognostic signature in ccRCC by both external and internal verification. Besides, our established model displayed significant associations with immune infiltration. In addition to original clinical parameters, our findings may further help clinicians in predicting patients’ survival status and creating individualized treatment plans.

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Section: Introductionmentioning

confidence: 93%

Six RNA binding proteins (RBPs) related prognostic model predicts overall survival for clear cell renal cell carcinoma and it is associated with immune infiltration

Xing

Luan

Liu

et al. 2021

Bosn J of Basic Med Sci

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“…Butyrate directly down-regulates the expression levels of reactive oxygen species and various inflammatory factors in the process of AS. Cyclooxygenase-2 is one of the inflammatory proteins, and butyrate can inhibit cyclooxygenase-2 mRNA binding, which results in decreased transcription of this inflammatory protein (Torun et al 2019). In an obese mouse model subjected to a high-fat diet, sodium butyrate supplementation reduced triglyceride, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) levels by 34%-42% (Fang et al 2019).…”

Section: Mechanism Of Butyrate Action On Asmentioning

confidence: 99%

Role and mechanism of action of butyrate in atherosclerotic diseases: a review

Yang

Guo

et al. 2021

J Appl Microbiol

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Butyrate is a bioactive molecule produced by the intestinal flora and plays a major role in a variety of inflammatory diseases. Increasing evidence indicates that butyrate can regulate the occurrence and development of atherosclerosis. Coincidentally, it reduces hyperlipidemia and hyperglycemia, which are major risk factors of atherosclerosis. However, the mechanism by which butyrate regulates the development of atherosclerosis remains unclear. In this article, we review the effect of butyrate treatment on atherosclerosis with a focus on the mechanisms of butyrate-mediated modulation of several atherosclerotic processes. These include the improvement of monocyte-endothelial interactions, macrophage lipid accumulation, smooth muscle cell proliferation and migration, and lymphocyte differentiation and function. The existing research indicates that butyrate treatment may be a potentially effective strategy for the prevention of atherosclerosis. Identity and underlying mechanisms of the molecular pathways of these interactions should be explored in the future to counter atherosclerosis effectively.

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“…Butyrate inhibits IL-13 and IL-15 production by Type 2 innate lymphoid cells. Butyrate downregulates various RNA binding proteins and thereby post transcriptionally downregulating the expression of inflammatory genes 143 . Sodium butyrate attenuates AngII induced hypertension, cardiac hypertrophy, cardiac fibrosis, and inflammation by inhibiting Cyclooxygenase-2 (COX2)/ Prostaglandin E2 (PGE2) pathway in a HDAC5/ HDAC6 dependent manner 144 .…”

Section: Is Butyrate An Alternative To Dexamethasone?mentioning

confidence: 99%

Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?

et al. 2021

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Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids leads to serious adverse events and disruption of the gut-lung axis. Various micronutrients and probiotic supplementations are known to aid in the reduction of hyperinflammation and restoration of gut microbiota. The attenuation of the deleterious immune response and hyperinflammation could be mediated by short chain fatty acids produced by the gut microbiota. Butyric acid, the most extensively studied short chain fatty acid, is known for its anti-inflammatory properties. Additionally, butyric acid has been shown to ameliorate hyperinflammation and reduce oxidative stress in various pathologies, including respiratory viral infections. In this review, the potential anti-inflammatory effects of butyric acid that aid in cytokine storm depletion, and its usefulness in effective management of critical illness related to CoVID-19 have been discussed.

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Butyrate mediated regulation of RNA binding proteins in the post-transcriptional regulation of inflammatory gene expression

Cited by 22 publications

References 55 publications

Six RNA binding proteins (RBPs) related prognostic model predicts overall survival for clear cell renal cell carcinoma and it is associated with immune infiltration

Six RNA binding proteins (RBPs) related prognostic model predicts overall survival for clear cell renal cell carcinoma and it is associated with immune infiltration

Role and mechanism of action of butyrate in atherosclerotic diseases: a review

Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?

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