Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?

Nithin, K K; Patil, Prakash; Bhandary, Satheesh Kumar; Haridas, Vikram; N, Suchetha Kumari; Sarathkumar, E.; Shetty, Praveenkumar

doi:10.12688/f1000research.51786.1

Cited by 10 publications

(3 citation statements)

References 147 publications

(173 reference statements)

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“…Inflammatory cytokines [IL-6, IL-8, IL-10, and tumor necrosis factor α (TNF-α)] were found to be high in number, leading to ARDS and multiple-organ dysfunction[ 77 , 78 ]. Butyric acid produced by intestinal bacteria is known to reduce cytokine storm[ 79 ]. Thus, the gut microbiota could help in reducing the prevalence of ARDS and sepsis, which are major mortality risks in COVID-19.…”

Section: Gi Manifestation and Gut Dysbiosis (Metabolic Dysfunction)mentioning

confidence: 99%

Modulation of gut microbiota as a potential therapy to manipulate drug-induced hepatic damage in COVID-19 patients

Ahsan¹,

Anwar²,

Munawar³

2023

World J Gastroenterol

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Coronavirus disease 2019 (COVID-19) infection caused by the severe acute respiratory syndrome coronavirus 2 virus, its symptoms, treatment, and post-COVID-19 effects have been a major focus of research since 2020. In addition to respiratory symptoms, different clinical variants of the virus have been associated with dynamic symptoms and multiorgan diseases, including liver abnormalities. The release of cytokines by the activation of innate immune cells during viral infection and the high doses of drugs used for COVID-19 treatment are considered major drivers of liver injury in COVID-19 patients. The degree of hepatic inflammation in patients suffering from chronic liver disease and having COVID-19 could be severe and can be estimated through different liver chemistry abnormality markers. Gut microbiota influences liver chemistry through its metabolites. Gut dysbiosis during COVID-19 treatment can promote liver inflammation. Here, we highlighted the bidirectional association of liver physiology and gut microbiota (gut-liver axis) and its potential to manipulate drug-induced chemical abnormalities in the livers of COVID-19 patients.

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“…Notably butyrate may play a role in preventing certain types of diarrheas and it has shown beneficial effects on some colonic pathologies [82][83][84]. The attenuation of the deleterious immune response and hyperinflammation could be mediated by SCFA produced by the gut microbiota [85].…”

Section: Butyratementioning

confidence: 99%

Epigenetics in Food Allergy and Immunomodulation

et al. 2021

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Food allergy (FA) is an increasing problem worldwide and, over recent years, its prevalence is rising in developed countries. Nowadays, the immunological and cellular processes that occur in the allergic reactions are not fully understood, which hampers the development of in vitro diagnostic tools and further treatment options. Moreover, allergic diseases could be reinforced by environmental exposure and genetic modifications. Gene expression can be controlled by different epigenetic mechanisms like DNA methylation, histone modifications, and microRNAs. In addition, several environmental factors such as dietary components (vitamin D, butyrate, folic acid) are able to regulate this epigenetic mechanism. All these factors produce modifications in immune genes that could alter the development and function of immune cells, and therefore the etiology of the disease. Furthermore, these epigenetic mechanisms have also an influence on immunomodulation, which could explain sustained responsiveness or unresponsiveness during immunotherapy due to epigenetic modifications in key genes that induce tolerance in several FA. Thus, in this review we focus on the different epigenetic mechanisms that occur in FA and on the influence of several dietary components in these gene modifications.

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“…are being recommended for proper immune function [143]. In addition, we recently made a detailed review and proposed a dietary supplement, sodium butyrate or butyric acid, which has an anti-inflammatory effects, could be an effective therapeutic strategy for COVID-19 prevention [144]. However, there is a general dearth of particular antiviral drugs that target the virus rather than simply providing symptomatic relief.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications

Patil

Shetty

Kuriakose

et al. 2021

IJMS

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Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has infected >235 million people and killed over 4.8 million individuals worldwide. Although vaccines have been developed for prophylactic management, there are no clinically proven antivirals to treat the viral infection. Continuous efforts are being made all over the world to develop effective drugs but these are being delayed by periodic outbreak of mutated SARS-CoV-2 and a lack of knowledge of molecular mechanisms underlying viral pathogenesis and post-infection complications. In this regard, the involvement of Annexin A2 (AnxA2), a lipid-raft related phospholipid-binding protein, in SARS-CoV-2 attachment, internalization, and replication has been discussed. In addition to the evidence from published literature, we have performed in silico docking of viral spike glycoprotein and RNA-dependent RNA polymerase with human AnxA2 to find the molecular interactions. Overall, this review provides the molecular insights into a potential role of AnxA2 in the SARS-CoV-2 pathogenesis and post-infection complications, especially thrombosis, cytokine storm, and insulin resistance.

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Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?

Cited by 10 publications

References 147 publications

Modulation of gut microbiota as a potential therapy to manipulate drug-induced hepatic damage in COVID-19 patients

Epigenetics in Food Allergy and Immunomodulation

Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications

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