Butyrate and propionate production from D-mannitol in the large intestine of pig and rat

Maekawa, M; Ushida, Kazunari; Hoshi, Seiko; Kashima, Naoko; Ajisaka, Katsumi; Yajima, Takaji

doi:10.3402/mehd.v17i3.7781

Cited by 8 publications

(9 citation statements)

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“…This suggests that conversion of mannitol by the mouse microbiota is not a major source of acetic acid production. This was previously shown in rats, where dietary supplementation of mannitol did not increase acetic and propionic acids, which means that the microbiota in different hosts have different potential to convert mannitol to SCFAs (Maekawa et al, 2005). Thus, the combination of environmental SCFAs and activation of the Ack pathway via fructose metabolism is one mechanism by which L. reuteri modulates phage production in the gut.…”

Section: Discussionmentioning

confidence: 52%

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Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri

Alexander

Pan

et al. 2019

Cell Host & Microbe

140

144

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Section: Discussionmentioning

confidence: 52%

“…reuteri can reduce fructose to mannitol (Arskö ld et al, 2008;Rodriguez et al, 2012). The microbiota, at least in pigs, can convert mannitol to SCFAs (Maekawa et al, 2005). However, our data show that the increase in acetic acid from mice fed fructose and L. reuteri is driven by L. reuteri AckA.…”

Section: Discussionmentioning

confidence: 59%

Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri

Alexander

Pan

et al. 2019

Cell Host & Microbe

140

144

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“…The product decomposed by Desulfovibrio and Oscillospira (e.g., butyrate, Hydrogen sulfide etc.) can protect the gastrointestinal tract and promote food digestion ( Fournier et al, 2003 ; Mackie et al, 2003 ; Maekawa et al, 2005 ). Phascolarctobacterium and Papillibacter are also proved to be related to volatile fatty acids (VFA) production, such as acetate and butyrate ( Dot et al, 1993 ; Watanabe et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

The Dynamic Distribution of Small-Tail Han Sheep Microbiota across Different Intestinal Segments

et al. 2018

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The sheep intestinal tract is characterized by a diverse microbial ecosystem that is vital for the host to digest diet material. The importance of gut microbiota (GM) of animals has also been widely acknowledged because of its pivotal roles in the health and well-being of animals. However, there are no relevant studies on GM of small-tail Han sheep, a superior mutton variety domestic in China. In this study, the structure and distribution of gut microflora were studied by high-throughput sequencing technology. Results showed a significant difference between jejunum and cecum, jejunum, and rectum. Meanwhile, the cecum and rectum not only display higher species richness but also exhibit higher similarity of the bacterial diversity than that of the jejunum based on the results of abundance-based coverage estimator (ACE), Chao1, and Shannon indexes. Firmicutes and Bacteroidetes were the predominant phyla in cecum and rectum, while higher relative abundances of Firmicutes and Cyanobacteria were observed in jejunum. At the genus level, Bacteroidetes, Ruminococcus, Lactobacillus, Flavonifractor, and Clostridium were the dominant genera in the cecum and rectum. An obvious dynamic distribution of Lactobacillus is continuously decreasing from the jejunum to the cecum, then to the rectum, whereas the result of Bacteroides is completely inverse. In addition, this study also found many kinds of bacteria associated with the production of volatile fatty acids (VFA) colonized in the large intestine. This study is the first to investigate the distribution of intestinal flora in small-tail Han sheep. The findings provide an important indication for diagnosis and treatment of intestinal diseases in small-tail Han sheep, as well as offer a direction for the development of intestinal microecological preparations.

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“…For instance, FOS increased mainly butyric acid and acetic acid concentrations in the human colon [ 31 ]. Mannitol, in turn, has showed to stimulate the generation of lactic acid, succinic acid and butyric acid and to reduce that of acetic acid in the hindgut and feces of rats, whereas inconsistent reports exists regarding propionate fermentation [ 32 , 33 ]. Difructose anhydride III feeding to rats increased especially acetic acid formation [ 34 ] which could be linked to the enhanced abundance of Ruminococcus sp .…”

Section: Prebiotic Properties Of Is and Effects Of Fermentationmentioning

confidence: 99%

Gut Function-Enhancing Properties and Metabolic Effects of Dietary Indigestible Sugars in Rodents and Rabbits

2015

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Indigestible sugars (iS) have received particular interest in food and nutrition research due to their prebiotic properties and other health benefits in humans and animals. The main aim of this review article is to summarize the current knowledge regarding digestive and health-enhancing properties of iS such as sugar alcohols, oligosacharides, and polysaccharides, in rodents and rabbits. Besides ameliorating gut health, iS ingestion also elicits laxative effects and stimulate intestinal permeability and fluid secretions, thereby shortening digesta transit time and increasing stool mass and quality. In rodents and rabbits, as hindgut fermenters, consumption of iS leads to an improved nutrient digestibility, too. Cecal fermentation of iS reduces luminal pH and extends wall tissue facilitating absorption of key dietary minerals across hindgut. The microbial fermentation of iS also enhances excessive blood nitrogen (N) flowing into the cecum to be used as N source for bacterial growth, enhancing N retention in cecotrophic animals. This review also highlights the impact of iS on improving lipid metabolism, mainly by lowering cholesterol and triglycerides levels in the blood. The paper serves as an index of the current knowledge of iS effects in rodents and rabbits and also identifies gaps of knowledge that need to be addressed by future research.

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Butyrate and propionate production from D-mannitol in the large intestine of pig and rat

Cited by 8 publications

References 0 publications

Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri

Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri

The Dynamic Distribution of Small-Tail Han Sheep Microbiota across Different Intestinal Segments

Gut Function-Enhancing Properties and Metabolic Effects of Dietary Indigestible Sugars in Rodents and Rabbits

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