Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia

Temizel, Ethem Mutlu; Batmaz, Hasan; Keskin, Ahmet; Orman, Abdülkadir; Gencoglu, H.; Çatik, Serkan; Topal, Onur

doi:10.1016/j.smallrumres.2015.02.016

Cited by 8 publications

(15 citation statements)

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“…Studies in cattle and sheep have indicated a decrease in the postpartum plasma leptin concentration (13,29). However, there is an increase in blood NEFA concentration and a decrease in body score, especially as a sign of negative energy balance in high milk-producing animals (30,31). Taken together, our observations of low serum leptin and an increase in metabolic requirements (meaning negative energy balance) agreed well with the study by Carcangiu et al (13) that reported that the high milk yield group had low plasma leptin concentration compared to the low milk yield group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pre- and postpartum serum leptin, ghrelin, and lipid levels in sheep

2018

Turk J Vet Anim Sci

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IntroductionAwassi sheep are primarily found in southeastern Turkey as well as the Middle East. Awassi sheep are a breed of dairy sheep bred for multiple lambing and high milk yield in Turkey (1). Pregnancy is the most important metabolic burden in ewes, which have multiple offspring (2,3). In this period, energy and protein intake usually do not cover the energy and protein requirements in many sheep herds (3,4).Leptin, a product of the ob gene, is a protein mainly secreted by white adipose tissue (5). This hormone is responsible for the long-term regulation of energy balance and depressing appetite (6). Leptin plays an important role in energy metabolism during pregnancy and lactation (7,8). Many studies showed that plasma leptin level increased during pregnancy and declined during the transition to lactation (9-12). Carcangiu et al. (13) reported that body condition scores were positively correlated with serum leptin concentration but were negatively correlated with milk yield after delivery in ewes with production levels. Additionally, leptin was negatively correlated with growth hormone (GH) and nonesterified fatty acid (NEFA) in the lactation periods (13).Otherwise, ghrelin mainly arises from the abomasum in ruminants. Ghrelin induces GH release and stimulates appetite in the brain (14-16). Ghrelin concentration increases prior to meals, but it is suppressed after feeding. Ghrelin also decreases fat oxidation and increases insulin concentration (17)(18)(19).The objective of the present study was to evaluate fluctuations and possible interactions of the leptin, ghrelin, and lipid profile of ewes in the pre-and postparturient periods and control sheep. Materials and methods Animals and nutritionThe present study was carried out in the town of Nilüfer in Bursa Province, Turkey. Pregnant Awassi ewes (last week before lambing) that were (n = 15) or were not pregnant (control group) (n = 15), weighing 68.4 ± 10.4 kg (53.4-80.6 kg), and aged 2 years were used in the study. All ewes were selected from among those that were to have twin lambs. During this study period, all sheep were fed a controlled diet and water was provided ad libitum. All animals were housed under the same conditions. The herd consisted of a Abstract: Serum leptin and ghrelin play important roles in energy metabolism and inducing appetite during pregnancy and lactation. We investigated the serum levels of leptin and ghrelin and their relationship with the duration of lactation and serum biochemical responses during the prepartum (last week before lambing) and postpartum periods in sheep. They were also evaluated between pregnant and nonpregnant (control ewes) ewes. For these purposes, pregnant (n = 15) and control Awassi ewes (n = 15) that were 2 years of age were used in this study. Blood samples were collected 1 week before the expected date of lambing (baseline) and for 12 weeks after parturitions. Serum leptin, ghrelin, cholesterol, triglyceride, VLDL, LDL, HDL, NEFA, and phospholipid levels were assayed. Leptin and ghrelin levels of the pr...

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Section: Discussionmentioning

confidence: 99%

Comparison of pre- and postpartum serum leptin, ghrelin, and lipid levels in sheep

2018

Turk J Vet Anim Sci

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“…Vitamin B12 (cyanocobalamin) administration has been advocated by Andrews (1997) and Rook (2000), as it is involved in gluconeogenesis. However, levels of vitamin B12 have been found to be normal in ewes affected by OPT (Souto and others 2019) and the administration of a combination of butaphosphan and cyanocobalamin to pregnant ewes not suffering from OPT did not have a significant effect on BHB or NEFA levels compared to controls, although insulin levels were significantly lower in treated sheep (Temizel and others 2015).…”

Section: Treatmentmentioning

confidence: 99%

Advances in managing pregnancy toxaemia in sheep

Crilly¹,

Phythian²,

Evans³

2021

In Practice

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Background: Ovine pregnancy toxaemia (OPT) is a metabolic disorder of ewes in late pregnancy. Cases are typically seen in ewes carrying multiple fetuses, hence the alternative name of ‘twin lamb disease’. The disease has been well known for many years. Despite this, the toll inflicted by the disease remains considerable, due both to the poor prognosis of clinically affected animals, even with appropriate treatment, and the impact of the provoking factors of under‐nutrition and concomitant disease on ewe morbidity, lamb survival and flock productivity. Cases of OPT are an indication of shortcomings in the management of late‐pregnancy ewes. Aim of the article: This article provides an update on the aetiopathogenesis, diagnosis, treatment and prevention of OPT, drawing on recently published studies.

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“…In a study by Rollin et al (2010) in dairy cows, no differences in phosphorus levels were observed between the groups receiving butaphosphan and cyanocobalamin, but Furll et al (2010) found a nonsignificant increase in phosphorus levels. Temizel et al (2015) investigated the prophylactic effects of butaphosphan and cyanocobalamin on pregnancy toxaemia in sheep and found no difference in phosphorus levels between the study groups, compared with the Ctrl ones. This may be on account of the short half-life of phosphorus and the fact that butaphosphan is a source of organic phosphorus (EMEA, 1999).…”

Section: Treatmentmentioning

confidence: 99%

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

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Background: Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.Objectives: It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.Methods: Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition.A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low-and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.Results: This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others. Conclusions:It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.

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Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia

Cited by 8 publications

References 14 publications

Comparison of pre- and postpartum serum leptin, ghrelin, and lipid levels in sheep

Comparison of pre- and postpartum serum leptin, ghrelin, and lipid levels in sheep

Advances in managing pregnancy toxaemia in sheep

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

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