Butanol production from hemicellulosic hydrolysate of corn fiber by a Clostridium beijerinckii mutant with high inhibitor-tolerance

Combination of RNA sequencing and metabolite data to elucidate improved toxic compound tolerance and butanol fermentation of Clostridium acetobutylicum from wheat straw hydrolysate by supplying sodium sulfide

“…Guo et al improved butanol production from non-detoxified corn fiber hydrolysate using an inhibitor-tolerant Clostridium beijerinckii mutant strain. With this strain, the final ABE concentration reached 10.6 g/L (Guo et al, 2013). Du obtained an improved butanol titer from non-detoxified corn fiber hydrolysate using a mutant strain and adding NH 4 HCO 3 and CaCO 3 et al to the hydrolysate .…”

“…However, the unavoidable side reactions during degradation of lignocellulose yield several toxic byproducts. Unfortunately, the mixture of inhibitors seriously restricts microorganism growth and the production of butanol (Guo et al, 2013). Because detoxification increases the overall cost of butanol production, recent research efforts have tended to utilize acid hydrolysate containing inhibitors directly.…”

Can Microbially Derived Advanced Biofuels Ever Compete with Conventional Bioethanol? A Critical Review

“…Researchers have examined a range of biomass sources including corn stover, corn fiber, barley straw, and switch grass, as well as a variety of pretreatment conditions to assess their influence on n-butanol production (Parekh and Blaschek 1999;Parekh and Formanek 1999;Qureshi et al 1999;Qureshi et al 2006;Ezeji et al 2007;Zhang et al 2009;Qureshi et al 2010;Lin et al 2011;Mu et al 2011;Guo et al 2012Guo et al , 2013. Sugar concentrations ranged from 31 to 58 g/L with solvent titers ranging from 2 to 26 g/L (Parekh and Blaschek 1999;Parekh and Formanek 1999;Qureshi et al 1999Qureshi et al , 2006Ezeji et al 2007;Zhang et al 2009;Qureshi et al 2010;Lin et al 2011;Mu et al 2011;Guo et al 2012Guo et al , 2013. The highest yield reported was 0.44 g/g (Qureshi et al 2006(Qureshi et al , 2010, and the highest productivity was 5 g/L/h ).…”

“…Climate change and energy security have placed enormous pressure on governments and industry to replace carbon-intensive petroleum with biomass-derived alternatives (Guo et al 2013;Su et al 2015). As a result of this global surge, bioethanol production and its use has increased exponentially in the last decade, reaching 25 billion gallons in 2013, which is more than three times higher than 2000 production levels (RFA 2015;Su et al 2015).…”

Advances in consolidated bioprocessing systems for bioethanol and butanol production from biomass: a comprehensive review

“…By use of lignocelluloses as substrate, three components, including acetone, butanol and ethanol (ABE) are simultaneously produced, in which butanol is the major product (Ezeji et al, 2012;Jurgens et al, 2012;Wen et al, 2014a,b). Different biomass such as wheat straw (Quershi et al, 2007;Nanda et al, 2014), rice straw (Gottumukkala et al, 2013(Gottumukkala et al, , 2014, barley straw (Quershi et al, 2010a), corn stover (Parekh et al, 1988;Quershi et al, 2010b), corn cob and fibers (Marshal et al, 1992;Guo et al, 2013), palm kernel cake (Shukor et al, 2014), cassava starch (Li et al, 2014a,b), pinewood and timothy grass (Nanda et al, 2014), switch grass (Quershi et al, 2010b;Gao et al, 2014), sag pith (Linggang et al, 2013) and dried distillers' grains have been used as substrates for ABE fermentation by numerous Clostridium strains such as C. acetobutylicum, C. aurantibutyricum, C. beijerinckii , C. cadaveris, C. pasteurianum, C. saccharoperbutylacetonicum, C. saccharobutylicum, C. sporogenes and C. tetanomorphum (Inui et al, 2008;Quershi et al, 2013). This process commonly occurs in two phases, including acidogenic phase where acetic and butyric acids are produced, and solventogenic phase where acids are used and ABE are generated.…”