Butafosfan E Cianocobalamina: Efeitos Indiretos Na Recuperação Da Glândula Mamária De Vacas Leiteiras Após Mastite Clínica

Tabeleão, Vinícius Coitinho; Pereira, Rubens Alves; Prietsch, Rafael da Fonseca; Feijó, Josiane de Oliveira; Bondan, Carlos; Mattei, Patrícia; Schmitt, Eduardo; Pino, Francisco Augusto Burkert Del; Corrêa, Márcio Nunes

doi:10.15210/sah.v4i3.7795

Cited by 4 publications

(2 citation statements)

References 26 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies carried out by our research group with cattle and sheep demonstrated the benefits of butaphosphane in modulating energy and lipid status. Individuals treated with butaphosphan during periods of intense immunological challenge, as the days around the parturition, demonstrated improved lipid and energy metabolism, resulting in a lower incidence of metabolic disorders and ameliorating productive and reproductive indexes, reflecting a general enhanced health status , Lima, 2014, Tabeleão et al, 2016, Pizoni et al, 2022. However, in this studies, as in others (Rollin et al, 2010, Furll et al, 2010, Temizel et al, 2015, the butaphosphan was used in association with cyanocobalamin (vitamin B12), an enzymatic co-factor of metylmalonyl -CoA mutase, that convert propionate to succinil CoA, an essential step to take part into acid citric cycle, to be used on gluconeogenesis (Kennedy et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Pro-inflammatory response markers and neutrophil activity index of mice treated with butaphosphan and challenged with bacterial endotoxin

Mattei

Jacometo²,

Pereira³

et al. 2022

RSD

Self Cite

View full text Add to dashboard Cite

Butaphosphan, an organic source of phosphorus, potentiates humoral and cellular immune responses, however, it is still not clear how this occurs. We evaluate the effect of subcutaneous administration of injectable butaphosphan on pro-inflammatory markers and neutrophil activity index of mice challenged with bacterial lipopolysaccharide. Forty-two mice were randomly divided into three groups: Butaphosphan 50 (BUT50, n=14), that received injections of 50 mg/kg of butaphosphan; Butaphosphan 200 (BUT200, n=14), that received injections of 200 mg/kg of butaphosphan and Control (CTL, n=15), that received placebo. Subcutaneous injections were performed twice daily, for eight consecutive days. At the 8th day, half of animals per group were randomly selected to be challenged with bacterial lipopolysaccharide. Two hours after the challenge animals were euthanized, blood and spleen collected to analyze hematological parameters, circulating levels of interleukin 6 (IL-6), 1β (IL-1B) and myeloperoxidase (MPO) tissue activity. Red blood cell count was higher in butaphosphan treated groups. White blood cell count was lower in BUT200/LPS, as consequence of the decreased neutrophil count. Defense cells and IL-6 were elevated in BUT200 group. The use of butaphosphan ameliorate inflammatory markers, both in challenged and not challenged animals.

show abstract

Section: Discussionmentioning

confidence: 99%

Pro-inflammatory response markers and neutrophil activity index of mice treated with butaphosphan and challenged with bacterial endotoxin

Mattei

Jacometo²,

Pereira³

et al. 2022

RSD

Self Cite

View full text Add to dashboard Cite

show abstract

“…The same effect was observed for embryo development, which was lower as the concentration of butafosfan increased, suggesting that butafosfan is detrimental for oocyte maturation. It was proposed that butafosfan may interfere with phosphorylation of molecules involved in cellular signalling (Tabeleão et al, 2017). To achieve competence, oocytes need to complete nuclear and cytoplasmic maturation (Ferreira et al, 2009), a process dependent on several signalling pathways, such as promoting maturation factor (PMF) and regulated by different kinases and phosphatases (Belloc et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effect of butafosfan supplementation during oocyte maturation on bovine embryo development

Hax

Rincón

Schneider

et al. 2019

Zygote

View full text Add to dashboard Cite

SummaryAround 60–80% of oocytes maturated in vivo reached competence, while the proportion of maturation in vitro is rarely higher than 40%. In this sense, butafosfan has been used in vivo to improve metabolic condition of postpartum cows, and can represent an alternative to increase reproductive efficiency in cows. The aim of this study was to evaluate the addition of increasing doses of butafosfan during oocyte maturation in vitro on the initial embryo development in cattle. In total, 1400 cumulus–oocyte complexes (COCs) were distributed in four groups and maturated according to supplementation with increasing concentrations of butafosfan (0 mg/ml, 0.05 mg/ml, 0.1 mg/ml and 0.2 mg/ml). Then, 20 oocytes per group were collected to evaluate nuclear maturation and gene expression on cumulus cells and oocytes and the remaining oocytes were inseminated and cultured until day 7, when blastocysts were collected for gene expression analysis. A dose-dependent effect of butafosfan was observed, with decrease of cleavage rate and embryo development with higher doses. No difference between groups was observed in maturation rate and expression of genes related to oocyte quality. Our results suggest that butafosfan is prejudicial for oocytes, compromising cleavage and embryo development.

show abstract

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

Denız¹,

Aksoy²

2022

Vet. Med. - Czech

View full text Add to dashboard Cite

Phosphorus is critical for life and an indispensable element for biologically occurring organic molecules such as DNA, ATP, and phosphoproteomes. Butafosfan is a synthetically produced organic phosphorous (phosphonic acid) compound that contains 17.3% phosphorus. It does not belong to the group of biologically occurring organic phosphorous compounds. Butafosfan has been used in many animal species as a metabolic stimulant interfering with energy metabolism. Vitamin B12 (VB12) is a unique cobalt-containing vitamin. It functions as a cofactor for the enzymes methionine synthase and methyl-malonyl-CoA mutase. It is necessary for the conversion of propionate into succinyl-CoA in ruminants. A combination of butafosfan and VB12 (iBC) has been available for veterinary use since 1958 and the first publication appeared in the 1970s in cows. However, the first molecular biological studies about its mode of action appeared in early 2000s. Recent studies revealed that iBC has significant effects on carbohydrate and lipid metabolism. Investigations between 1970 and 1994 focused mainly on cows at risk of metabolic and reproductive disease in the dry period. Studies as of 2000 investigated its efficacy for the prevention and treatment of subclinical and secondary ketosis, adjunctive/supportive therapy for displaced abomasum operation, milk fever, improvement of postoperative rumen activity, uterus involution, and mastitis in transition dairy cows.

show abstract

Butafosfan E Cianocobalamina: Efeitos Indiretos Na Recuperação Da Glândula Mamária De Vacas Leiteiras Após Mastite Clínica

Cited by 4 publications

References 26 publications

Pro-inflammatory response markers and neutrophil activity index of mice treated with butaphosphan and challenged with bacterial endotoxin

Pro-inflammatory response markers and neutrophil activity index of mice treated with butaphosphan and challenged with bacterial endotoxin

Effect of butafosfan supplementation during oocyte maturation on bovine embryo development

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

Contact Info

Product

Resources

About