Buschke-Löwenstein tumor: Squamous cell carcinoma of the anogenital region

Turkalj, Ivan; Djilas-Ivanovic, Dragana; Boskov, Nedeljka; Petrov, B. D.; Stajer, Laszlo; Ivković-Kapicl, Tatjana

doi:10.2298/sarh1406356t

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…It has benign appearance on histopathology but is locally destructive. It carries a high recurrence rate and a significant potential for malignant transformation [4,13]. In our series, HPV-associated SCC was detected in two patients.…”

Section: Discussionmentioning

confidence: 53%

“…Most of the non-melanocytic skin cancers seen in these anatomical regions are squamous cell cancers (SCC), and fewer are basal cell cancers. Chronic wound scars, hidradenitis suppurativa (HS), pilonidal sinus disease (PSD), human papillomavirus (HPV) -related lesions, and giant Condyloma acuminata (Buschke-Lowenstein tumor) are known etiological causes[2,3,4]. Patients often suffer from chronic sacrococcygeal diseases.…”

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confidence: 99%

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Squamous cell skin carcinoma due to chronic sacrococcygeal diseases

et al. 2022

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Introduction/Objective. Sacrococcygeal region squamous cell cancers (SCC) due to chronic sacrococcygeal diseases of skin are rare malignancies. The anatomical relation with the anus represents a challenge for diagnosis and surgical treatment. The oncological treatment algorithm is still controversial. Here, we investigated the clinicopathologic features of skin cancer of the sacrococcygeal region in a total of 10 cases from a surgical oncology reference center. Methods. We retrospectively analyzed the patients who underwent surgery for sacrococcygeal region skin SCC between January 2010 and July 2020. Results. All patients were male, and the mean age was 52.9?10.5 years. In the etiology, five patients had hidradenitis suppurativa, 2 had Human papillomavirus associated condyloma (Buschke-Lowenstein tumor), and 3 had pilonidal sinus disease. The mean time between the development of the lesion and malignancy diagnosis was 21.7?5.8 years. In the preoperative evaluation, three patients had bone invasion. None of the patients had anal sphincter or rectal invasion. Also, no patient had lymph node metastasis or distant metastasis. Wide local excision (WLE) was performed in all patients; 3 of them with bone resection. Adjuvant chemoradiotherapy was applied to five patients. In a 28.5?13.7 months follow-up, local recurrence occurred in 5 patients and WLE has performed again in these patients. Of these 5 patients, 2 eventually became metastatic. Finally, 3 patients died due to disease and 6 patients are still free of diseases. Conclusion. Sacrococcygeal region SCCs may rarely develop after a long interval from hidradenitis suppurativa, pilonidal sinus disease, and condyloma acuminata. Anal sphincter-sparing WLE can be applied, but sphincter dysfunction may occur. The disease is associated with a high risk of relapse and poor survival.

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Section: Discussionmentioning

confidence: 53%

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confidence: 99%

Squamous cell skin carcinoma due to chronic sacrococcygeal diseases

et al. 2022

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“…Squamous cell carcinoma is typically well differentiated, and its distant metastases are rarely observed. 12 Although treatment of giant condylomas is debatable, methods of topical treatment, surgical intervention or immunotherapy can be tried. In very large lesions, chemotherapy and radiotherapy become ineffective and high rates of recurrences are observed with the use of topical agents.…”

Section: Discussionmentioning

confidence: 99%

“…14 Cases with giant condyloma acuminata should be verified with computed tomography (CT) or magnetic resonance imaging for the presence of internal organ and lymph node involvement. 12,15,16 In patients with lymph node involvement, lymph node dissection should be performed, and the patient should be kept under oncological control. In our patient, no lymph node involvement was observed on pre-and postoperative CT images.…”

Section: Discussionmentioning

confidence: 99%

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Invasive squamous cell carcinoma originating from a giant penile condyloma

Sır

Güngör²,

Üçer

et al. 2016

Int J STD AIDS

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In this case study, we present an unusual case with squamous cell carcinoma originating from a giant condyloma acuminata completely surrounding the penis. A 57-year-old circumcised heterosexual male patient presented with a penile lesion existing for 20 years. Incisional biopsy revealed acanthosis of the squamous epithelium. The patient was operated on under spinal anaesthesia. The lesion was resected circumferentially with macroscopic clearance, resulting in complete degloving of the penile shaft. Neurovascular bundles were preserved. The penile skin was constructed with a split thickness skin graft. Histopathological analysis of the lesion revealed an invasive and well-differentiated squamous cell carcinoma arising on a condyloma, and the surgical margins were free from tumour. The patient was staged as G2 T1 N0 M0 and was followed for one year. He did not have any erectile dysfunction and could engage in intercourse. Pelvic tomographic and physical examination findings did not reveal any episode of recurrence or metastasis. When encountering patients with giant condyloma acuminata, it should not be forgotten that it may be accompanied by squamous cell carcinoma. In addition, tissue excision should be as extensive as possible while keeping in mind the importance of the function. This is the first case of a penile-degloving surgery for giant penile condyloma, supporting conservative and preserving penile surgery for such tumours.

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