Introduction/Objective. Sacrococcygeal region squamous cell cancers (SCC) due
to chronic sacrococcygeal diseases of skin are rare malignancies. The
anatomical relation with the anus represents a challenge for diagnosis and
surgical treatment. The oncological treatment algorithm is still
controversial. Here, we investigated the clinicopathologic features of skin
cancer of the sacrococcygeal region in a total of 10 cases from a surgical
oncology reference center. Methods. We retrospectively analyzed the
patients who underwent surgery for sacrococcygeal region skin SCC between
January 2010 and July 2020. Results. All patients were male, and the mean
age was 52.9?10.5 years. In the etiology, five patients had hidradenitis
suppurativa, 2 had Human papillomavirus associated condyloma
(Buschke-Lowenstein tumor), and 3 had pilonidal sinus disease. The mean time
between the development of the lesion and malignancy diagnosis was 21.7?5.8
years. In the preoperative evaluation, three patients had bone invasion.
None of the patients had anal sphincter or rectal invasion. Also, no patient
had lymph node metastasis or distant metastasis. Wide local excision (WLE)
was performed in all patients; 3 of them with bone resection. Adjuvant
chemoradiotherapy was applied to five patients. In a 28.5?13.7 months
follow-up, local recurrence occurred in 5 patients and WLE has performed
again in these patients. Of these 5 patients, 2 eventually became
metastatic. Finally, 3 patients died due to disease and 6 patients are still
free of diseases. Conclusion. Sacrococcygeal region SCCs may rarely develop
after a long interval from hidradenitis suppurativa, pilonidal sinus
disease, and condyloma acuminata. Anal sphincter-sparing WLE can be applied,
but sphincter dysfunction may occur. The disease is associated with a high
risk of relapse and poor survival.