Invasive squamous cell carcinoma originating from a giant penile condyloma

Abstract

In this case study, we present an unusual case with squamous cell carcinoma originating from a giant condyloma acuminata completely surrounding the penis. A 57-year-old circumcised heterosexual male patient presented with a penile lesion existing for 20 years. Incisional biopsy revealed acanthosis of the squamous epithelium. The patient was operated on under spinal anaesthesia. The lesion was resected circumferentially with macroscopic clearance, resulting in complete degloving of the penile shaft. Neurovascular bundles were preserved. The penile skin was constructed with a split thickness skin graft. Histopathological analysis of the lesion revealed an invasive and well-differentiated squamous cell carcinoma arising on a condyloma, and the surgical margins were free from tumour. The patient was staged as G2 T1 N0 M0 and was followed for one year. He did not have any erectile dysfunction and could engage in intercourse. Pelvic tomographic and physical examination findings did not reveal any episode of recurrence or metastasis. When encountering patients with giant condyloma acuminata, it should not be forgotten that it may be accompanied by squamous cell carcinoma. In addition, tissue excision should be as extensive as possible while keeping in mind the importance of the function. This is the first case of a penile-degloving surgery for giant penile condyloma, supporting conservative and preserving penile surgery for such tumours.

Molecular mechanism of microRNA-26a regulation of phosphatase and tensin homolog gene in condyloma acuminatum and penile squamous cell carcinoma

“…CA is characterized by a high recurrence rate, and some persistent high-risk HPV infections may also cause malignant transformation, making clinical treatment difficult and imposing heavy psychological and economic burdens on the patients and their families. 25 , 26 There is thus an urgent need to understand the pathogenesis of HPV-associated CA and PSCC, to aid the discovery of effective treatment and prevention methods.…”

A rare case of self‐healing giant condyloma acuminatum

“…The clinical features of GCA are progression of exophytic, ulcerative, and cauliflower-shaped tumors, it has significant dimensions and may undergo malignant transformation such as squamous cell carcinoma or cervical cancer. 4 Because of bleeding, recurrence, intolerance of patients and other factors, it is difficult to treat GCA. Surgical excision is the first-line therapy for GCA because it quickly removes the large mass.…”