Burn Injury Management, Pathophysiology and Its Future Prospectives

Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. One plant that has received the most attention for its anti-diabetic properties is bitter melon, Momordica charantia (M. charantia), commonly referred to as bitter gourd, karela and balsam pear. Its fruit is also used for the treatment of diabetes and related conditions amongst the indigenous populations of Asia, South America, India and East Africa. Abundant pre-clinical studies have documented in the anti-diabetic and hypoglycaemic effects of M. charantia through various postulated mechanisms. However, clinical trial data with human subjects are limited and flawed by poor study design and low statistical power. The present review is an attempt to highlight the antidiabetic activity as well as phytochemical and pharmacological reports on M. charantia and calls for better-designed clinical trials to further elucidate its possible therapeutic effects on diabetes.

Section: Cultivation and Collectionmentioning

confidence: 99%

Role of Karela in Diabetes: A Review

Sharma¹,

Kumar

2023

“…[66][67] Essential oils have been used for their advantages to health, beauty, and general well-being since prehistoric times. [68] Over the course of the past few decades, there has been an increase in the level of concern regarding the possible risks that manmade chemicals pose to human health. As a consequence of this, there has been a general upward trend line in the utilisation of natural ingredients to improve the health and beauty of humans.…”

Section: Application Of Essential Oil In Cosmeticmentioning

confidence: 99%

Role of Essential Oils and Bioactive Components for Manufacturing Cosmetic Items

Aditi¹,

Dabral²

2023

The cosmetics industry has been forced to search for new active chemicals as a result of increasing customer demand as well as stricter international regulations. Botanical extract offers a source of new active chemicals that is nearly endless and may be used to make cosmetics. Due to their olfactory character in the creation of fragrances and perfumes and the many beneficial properties of their individual components (EOCs), essential oils (EOs) are becoming increasingly popular natural ingredients in the cosmetics and toiletries industry. These properties include anti-inflammatory, antimicrobial, and antioxidant properties (e.g., moisturizers, lotions and cleanser in skin care cosmetics; conditioners, masks or antidandruff products in hair care products; lipsticks, or fragrances in perfumery). It is difficult to generalise the possible applications of essential oils in cosmetics and toiletries because each essential oil has its own unique chemical profile, which is connected with its own particular collection of benefits. Instead, formulators need to make an effort to discover acceptable mixes of essential oils or essential oil compounds in order to get the results they want from the completed goods. This paper presents a detailed examination of the existing research on the usage of essential oils and essential oil compounds (EOs and EOCs) in the cosmetics sector. In addition, we will focus on a few critical topics regarding the safety of essential oils and essential oil compounds used in the cosmetics sector. When formulators of cosmetics are working to perfect products that are based on botanical extracts, they are very likely to find the information offered in this review to be valuable.

“…There are two distinct roles that microRNAs can play in the body depending on the function of the genes that they target: onco-miRNAs and tumour suppressor miRNAs. More than half of all miRNA genes are situated in close proximity to CGIs, which renders them amenable to epigenetic control [25]. Recent research has shed light on how miRNAs work in virtually every subtype of cancer, which was previously unknown.…”

Section: Non-coding Rnasmentioning

confidence: 99%

Herbal used as Epigenetic for Cancer Treatment

Navadiya¹,

Goti²,

Raloliya³

et al. 2023

Patterns of chromatin accessibility, which are in turn altered by epigenetic mechanisms, are responsible for determining the interactions that take place between transcription machinery, genes, and the cis-regulatory elements of those genes. Mutations that interfere with epigenetic processes frequently have the unfortunate side effect of causing cancer. Since these mutations can be undone, numerous anticancer treatments that target epigenetic pathways are now being developed and evaluated. (Cancer) is becoming more and more common everywhere. This decline in clinical outcomes is a result of a number of factors, including late diagnosis, a lack of efficient treatments for particular cancer subtypes, and drug resistance. Treatment resistance and stemness traits have been recognised as markers of this disease, and it has been demonstrated that epigenetic changes play a role in the process of cancer growth. Understanding these alterations and how they impact cancer carcinogenesis treatment is challenging but crucial. However, it may be able to provide the special knowledge needed to use these alterations as potential diagnostic, prognostic, therapeutic agents, and predictors of treatment efficacy. This underlines the importance of continued research to advance our knowledge of cancer carcinogenesis and epigenetics and help us overcome these challenges. This review aims to provide an overview of the state of the art in epigenetics research for cancer detection and treatment and to stimulate discussion on this subject.